ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Cell-free DNA (cfDNA) holds significant promise for diagnostic and therapeutic advancements in medicine. This review delineates the utility of cfDNA diagnostics its potential through clearance mechanisms an array diseases. Damage-associated molecular patterns (DAMPs) are endogenous molecules released by host cells during stress, or injury. As a trigger inflammatory responses via damage-associated (DAMPs), cfDNA's removal nanotechnological approaches can attenuate inflammation promote tissue repair. While application is particularly auspicious cancer, sepsis, conditions, it confronted with challenges including toxicity, specificity, rigors clinical trial validation. Collectively, this novel targets to inform development innovative treatment strategies.

Язык: Английский