Clearance of Cell-Free DNA: A Novel Target for Therapeutic Utilization in Multiple Systemic Disorders DOI
Wenjun Zhang, Xuan Jing, Bing Li

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Cell-free DNA (cfDNA) holds significant promise for diagnostic and therapeutic advancements in medicine. This review delineates the utility of cfDNA diagnostics its potential through clearance mechanisms an array diseases. Damage-associated molecular patterns (DAMPs) are endogenous molecules released by host cells during stress, or injury. As a trigger inflammatory responses via damage-associated (DAMPs), cfDNA's removal nanotechnological approaches can attenuate inflammation promote tissue repair. While application is particularly auspicious cancer, sepsis, conditions, it confronted with challenges including toxicity, specificity, rigors clinical trial validation. Collectively, this novel targets to inform development innovative treatment strategies.

Language: Английский

Cell-free DNA-scavenging nano/microsystems for immunotherapy DOI
Wenhan Zhao, Yang Zhou, Lichen Yin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113609 - 113609

Published: March 1, 2025

Language: Английский

Citations

0
Clearance of Cell-Free DNA: A Novel Target for Therapeutic Utilization in Multiple Systemic Disorders DOI
Wenjun Zhang, Xuan Jing, Bing Li

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Cell-free DNA (cfDNA) holds significant promise for diagnostic and therapeutic advancements in medicine. This review delineates the utility of cfDNA diagnostics its potential through clearance mechanisms an array diseases. Damage-associated molecular patterns (DAMPs) are endogenous molecules released by host cells during stress, or injury. As a trigger inflammatory responses via damage-associated (DAMPs), cfDNA's removal nanotechnological approaches can attenuate inflammation promote tissue repair. While application is particularly auspicious cancer, sepsis, conditions, it confronted with challenges including toxicity, specificity, rigors clinical trial validation. Collectively, this novel targets to inform development innovative treatment strategies.

Language: Английский

Citations

0