Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
57(23), С. 6926 - 6929
Опубликована: Апрель 19, 2018
Abstract
A
large
number
of
reagents
have
been
developed
for
the
synthesis
trifluoromethylated
compounds.
However,
an
ongoing
challenge
in
trifluoromethylation
reaction
is
use
less
expensive
and
practical
trifluoromethyl
sources.
We
report
herein
unprecedented
direct
(hetero)arenes
using
trifluoromethanesulfonic
anhydride
as
a
radical
reagent
by
merging
photoredox
catalysis
pyridine
activation.
Furthermore,
introduction
both
CF
3
OTf
groups
into
internal
alkynes
to
access
tetrasubstituted
alkenes
was
achieved.
Since
low‐cost
abundant
chemical,
this
method
provides
cost‐efficient
route
Journal of the American Chemical Society,
Год журнала:
2016,
Номер
138(39), С. 12692 - 12714
Опубликована: Сен. 15, 2016
This
Perspective
illustrates
the
defining
characteristics
of
free
radical
chemistry,
beginning
with
its
rich
and
storied
history.
Studies
from
our
laboratory
are
discussed
along
recent
developments
emanating
others
in
this
burgeoning
area.
The
practicality
chemoselectivity
reactions
enable
rapid
access
to
molecules
relevance
drug
discovery,
agrochemistry,
material
science,
other
disciplines.
Thus,
these
reactive
intermediates
possess
inherent
translational
potential,
as
they
can
be
widely
used
expedite
scientific
endeavors
for
betterment
humankind.
Chemical Reviews,
Год журнала:
2019,
Номер
119(14), С. 8701 - 8780
Опубликована: Июнь 25, 2019
Organosulfur
compounds
have
long
played
a
vital
role
in
organic
chemistry
and
the
development
of
novel
chemical
structures
architectures.
Prominent
among
these
organosulfur
are
those
involving
sulfur(IV)
center,
which
been
subject
countless
investigations
over
more
than
hundred
years.
In
addition
to
list
textbook
sulfur-based
reactions,
there
has
sustained
interest
organosulfur(IV)
recent
Of
particular
within
is
ease
with
synthetic
chemist
can
effect
wide
range
transformations
through
either
bond
formation
or
cleavage
at
sulfur.
This
review
aims
cover
developments
past
decade
molecules
provide
insight
into
both
reactions
critically
rely
on
this
versatile
element
diverse
scaffolds
that
thereby
be
synthesized.
Science,
Год журнала:
2019,
Номер
365(6451), С. 360 - 366
Опубликована: Июль 25, 2019
Two-for-one
approach
to
photoredox
In
catalysis,
an
excited
chromophore
typically
activates
a
single
reactant
either
by
oxidizing
or
reducing
it.
Ghosh
et
al.
used
semiconductor
catalyst
activate
two
reactants
at
once
quenching
both
electron
and
the
residual
positive
hole
(see
Perspective
Swift).
As
such,
different
reactive
carbon
halide
fragments
could
be
appended
separate
sites
on
aryl
ring.
The
also
tolerated
strong
nucleophiles
such
as
cyanide
recovered
easily
reused.
Science
,
this
issue
p.
360
;
see
320
Chemical Reviews,
Год журнала:
2017,
Номер
117(13), С. 9302 - 9332
Опубликована: Апрель 26, 2017
Azines,
which
are
six-membered
aromatic
compounds
containing
one
or
more
nitrogen
atoms,
serve
as
ubiquitous
structural
cores
of
species
with
important
applications
in
biological
and
materials
sciences.
Among
a
variety
synthetic
approaches
toward
azines,
C-H
functionalization
represents
the
most
rapid
atom-economical
transformation,
it
is
advantageous
for
late-stage
azine-containing
functional
molecules.
Since
azines
have
several
bonds
different
reactivities,
development
new
reactions
that
allow
regioselective
fashion
has
comprised
central
issue.
This
review
describes
recent
advances
categorized
follows:
(1)
SNAr
reactions,
(2)
radical
(3)
deprotonation/functionalization,
(4)
metal-catalyzed
reactions.
ACS Central Science,
Год журнала:
2017,
Номер
3(6), С. 647 - 653
Опубликована: Май 17, 2017
Photocatalysis
for
organic
synthesis
has
experienced
an
exponential
growth
in
the
past
10
years.
However,
variety
of
experimental
procedures
that
have
been
reported
to
perform
photon-based
catalyst
excitation
hampered
establishment
general
protocols
convert
visible
light
into
chemical
energy.
To
address
this
issue,
we
designed
integrated
photoreactor
enhanced
photon
capture
and
excitation.
Moreover,
evaluation
new
reactor
eight
photocatalytic
transformations
are
widely
employed
medicinal
chemistry
settings
confirmed
significant
performance
advantages
optimized
design
while
enabling
a
standardized
protocol.
Angewandte Chemie International Edition,
Год журнала:
2019,
Номер
58(41), С. 14615 - 14619
Опубликована: Авг. 7, 2019
Abstract
Incorporation
of
the
CF
3
group
into
arenes
has
found
increasing
importance
in
drug
discovery.
Herein,
we
report
first
photoredox‐catalyzed
cross‐coupling
aryl
thianthrenium
salts
with
a
copper‐based
trifluoromethyl
reagent,
which
enables
site‐selective
late‐stage
trifluoromethylation
arenes.
The
reaction
proceeds
broad
functional
tolerance,
even
for
complex
small
molecules
on
gram
scale.
method
was
further
extended
to
produce
pentafluoroethylated
derivatives.
Green Synthesis and Catalysis,
Год журнала:
2020,
Номер
1(1), С. 1 - 11
Опубликована: Июнь 1, 2020
Despite
their
impressive
capacity
to
access
diverse
functional
groups
and
synthesize
structurally
complex
molecules,
the
majority
of
organic
reactions
suffers
from
harsh
conditions,
low
atom
economy,
hazardous
waste
production.
The
goal
our
research
is
geared
towards
developing
efficient
methods
minimize
adverse
environmental
impact
contributing
chemical
sustainability.
Herein,
we
illustrate
three
distinct
green
approaches,
studying
novel
reactivities
with
environmentally
innocuous
reagents
improve
synthetic
efficiency,
utilization
natural
feedstocks,
employment
energy
facilitate
various
important
transformations.
From
this
perspective
article,
hope
provide
an
overview
chemistry
inspire
expansion
field
in
future.
Chinese Journal of Chemistry,
Год журнала:
2018,
Номер
36(7), С. 644 - 659
Опубликована: Апрель 17, 2018
Abstract
In
the
last
few
years,
photochemical
and
electrochemical
CO
2
transformations
have
attracted
increasing
attention
in
response
to
topical
interest
renewable
energy
green
chemistry.
The
present
minireview
offers
an
overview
about
current
approaches
for
carbon
dioxide
fixation
with
organic
compounds.
Valuable
products,
including
carboxylic
acids
heterocyclic
compounds,
are
accessible
through
carboxylation
carboxylative
cyclization,
respectively.
processes,
photo‐
or
electro‐induced
radical
ions
other
high‐energy
compounds
considered
as
key
intermediates
react
.
Besides,
activation
of
produce
anion
has
also
been
reported.
