Photoacoustic
(PA)
imaging
and
photothermal
therapy
(PTT)
have
attracted
extensive
attention
in
disease
diagnosis
treatment.
Although
many
exogenous
contrast
agents
been
developed
for
PA
PTT,
the
design
guidelines
to
amplify
their
performances
remain
challenging
are
highly
demanded.
Semiconducting
polymer
nanoparticles
(SPNs)
composed
of
polymers
with
π-electron
delocalized
backbones
can
be
designed
PTT
performance,
because
clear
structure-property
relation
versatility
modifying
molecular
structures
tune
photophysical
properties.
This
review
summarizes
recent
advances
photoacoustic
applications
semiconducting
a
focus
on
signal
amplification
second
near-infrared
(NIR-II,
1000-1700
nm)
construction.
The
strategies
such
as
screening,
fluorescence
quenching,
accelerated
heat
dissipation,
size-dependent
dissipation
first
discussed
brightness
SPNs
vivo
PA.
approaches
shifting
absorption
NIR-II
then
introduced
so
improve
tissue
penetration
depth
therapy.
At
last,
current
challenges
perspectives
field
discussed.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(25), С. 9888 - 9907
Опубликована: Фев. 12, 2020
Aggregation-induced
emission
(AIE)
describes
a
photophysical
phenomenon
in
which
molecular
aggregates
exhibit
stronger
than
the
single
molecules.
Over
course
of
last
20
years,
AIE
research
has
made
great
strides
material
development,
mechanistic
study
and
high-tech
applications.
The
achievements
demonstrate
that
show
many
properties
functions
are
absent
species.
In
this
review,
we
summarize
advances
field
its
related
areas.
We
specifically
focus
on
new
materials
attained
by
beyond
microscopic
level.
hope
review
will
inspire
more
into
ensembles
at
meso
level
lead
to
significant
progress
biological
science.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(25), С. 9868 - 9886
Опубликована: Март 4, 2020
Abstract
The
concept
of
aggregation‐induced
emission
(AIE)
has
opened
new
opportunities
in
many
research
fields.
Motivated
by
the
unique
feature
AIE
fluorogens
(AIEgens),
during
past
decade,
molecular
probes
and
nanoparticle
(NP)
have
been
developed
for
sensing,
imaging
theranostic
applications
with
excellent
performance
outperforming
conventional
fluorescent
probes.
This
Review
summarizes
latest
advancement
NP
their
emerging
biomedical
applications.
Special
focus
is
to
reveal
how
are
evolved
development
multifunctional
AIEgens,
strategies
overcome
limitations
traditional
more
translational
via
fluorescence
imaging,
photoacoustic
image‐guided
photodynamic/photothermal
therapy.
outlook
discusses
challenges
future
AIEgens
advance
field.
Chemical Society Reviews,
Год журнала:
2020,
Номер
49(4), С. 1144 - 1172
Опубликована: Янв. 1, 2020
This
review
presents
comprehensive
discussions
on
the
recent
development
in
supramolecular
materials
based
luminogens
with
aggregation-induced
emission
(AIE)
characteristics.
Chemical Society Reviews,
Год журнала:
2020,
Номер
49(22), С. 8179 - 8234
Опубликована: Янв. 1, 2020
Phototheranostics
represents
a
promising
direction
for
modern
precision
medicine,
which
has
recently
attracted
great
research
interest
from
multidisciplinary
areas.
Organic
optical
agents
including
small
molecular
fluorophores,
semiconducting/conjugated
polymers,
aggregation-induced
emission
luminogens,
etc.
with
tuneable
photophysical
properties,
high
biosafety
and
biocompatibility,
facile
processability
ease
of
functionalization
have
delivered
encouraging
performance
in
disease
phototheranostics.
This
review
summarizes
the
recent
progress
organic
phototheranostic
an
emphasis
on
main
strategies
to
manipulate
three
excitation
energy
dissipation
pathways,
namely,
radiative
decay,
thermal
deactivation,
intersystem
crossing,
assistance
Jablonski
diagram,
particularly
showcases
how
diagram
been
guiding
design
molecule
aggregate
levels
promote
outcomes.
Molecular
nanoengineering
modulate
processes
convert
absorbed
photons
into
fluorescent/phosphorescent/photoacoustic
signals
and/or
photodynamic/photothermal
curing
effects
improved
phototheranostics
are
elaborated.
Noteworthily,
adaptive
activatable
transformable
functions
demand,
regulation
such
as
chemiexcitation
efficacies
also
included.
A
brief
summary
discussion
current
challenges
future
perspectives
this
field
is
further
presented.
Advanced Materials,
Год журнала:
2020,
Номер
32(11)
Опубликована: Фев. 5, 2020
Abstract
Traditional
photothermal
therapy
requires
high‐intensity
laser
excitation
for
cancer
treatments
due
to
the
low
conversion
efficiency
(PCE)
of
agents
(PTAs).
PTAs
with
ultra‐high
PCEs
can
decrease
required
excited
light
intensity,
which
allows
safe
and
efficient
in
deep
tissues.
In
this
work,
a
PTA
is
synthesized
high
PCE
88.3%
based
on
BODIPY
scaffold,
by
introducing
CF
3
“barrier‐free”
rotor
meso
‐position
(tfm‐BDP).
both
ground
state,
moiety
tfm‐BDP
has
no
energy
barrier
rotation,
allowing
it
efficiently
dissipate
absorbed
(NIR)
photons
as
heat.
Importantly,
barrier‐free
rotation
be
maintained
after
encapsulating
into
polymeric
nanoparticles
(NPs).
Thus,
irradiation
intensity
(0.3
W
cm
−2
,
808
nm)
lead
complete
tumor
ablation
tumor‐bearing
mice
intravenous
injection
NPs.
This
strategy
“barrier‐free
rotation”
provides
new
platform
future
design
PTT
clinical
treatment.
Aggregate,
Год журнала:
2020,
Номер
1(1), С. 80 - 106
Опубликована: Дек. 1, 2020
Abstract
Theranostics
referring
to
the
ingenious
integration
of
diagnostics
and
therapeutics
has
garnered
tremendous
attention
in
these
years
as
it
provides
a
promising
opportunity
for
modern
personalized
precision
medicine.
By
virtue
good
biocompatibility,
outstanding
fluorescence
property,
easy
processability
functionalization,
promoted
photosensitizing
efficiency,
well
facile
construction
multi‐modality
theranostics,
fluorophores
with
aggregation‐induced
emission
(AIE)
characteristics
exhibit
inexhaustible
vigorous
vitality
field
theranostics.
Numerous
significant
breakthroughs
state‐of‐the‐art
progression
have
been
witnessed
past
few
years.
This
review
highlights
aggregation‐enhanced
superiorities
AIE
luminogens
(AIEgens)
disease
theranostics
mainly
involving
diagnostic
imaging
(fluorescence
room
temperature
phosphorescence),
therapeutic
intervention
(photodynamic
therapy),
feasibility
based
on
experimental
measurements
theoretical
simulations.
Additionally,
latest
advanced
developments
AIEgens
aspect
corresponding
strategies
design
highly
effective
AIE‐active
through
triggering
aggregation
formation
are
comprehensively
summarized.
Moreover,
brief
conclusion
discussion
current
challenges
future
perspectives
this
area
is
further
presented.
Advanced Materials,
Год журнала:
2020,
Номер
32(36)
Опубликована: Июль 30, 2020
Abstract
Molecular
science
entails
the
study
of
structures
and
properties
materials
at
level
single
molecules
or
small
interacting
complexes
molecules.
Moving
beyond
well‐defined
complexes,
aggregates
(i.e.,
irregular
clusters
many
molecules)
serve
as
a
particularly
useful
form
that
often
display
modified
wholly
new
compared
to
their
molecular
components.
Some
unique
phenomena
such
polymorphic
aggregates,
aggregation‐induced
symmetry
breaking,
cluster
excitons
are
only
identified
in
few
examples
exotic
features.
Here,
by
virtue
flourishing
research
on
emission,
concept
“aggregate
science”
is
put
forward
fill
gaps
between
aggregates.
Structures
aggregate
scale
also
systematically
summarized.
The
structure–property
relationships
established
for
expected
contribute
technological
development.
Ultimately,
may
become
an
interdisciplinary
field
serves
general
platform
academic
research.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Март 9, 2020
Abstract
Fluorescence
imaging
in
near-infrared
IIb
(NIR-IIb,
1500–1700
nm)
spectrum
holds
a
great
promise
for
tissue
imaging.
While
few
inorganic
NIR-IIb
fluorescent
probes
have
been
reported,
their
organic
counterparts
are
still
rarely
developed,
possibly
due
to
the
shortage
of
efficient
materials
with
long
emission
wavelength.
Herein,
we
propose
molecular
design
philosophy
explore
pure
fluorophores
by
manipulation
effects
twisted
intramolecular
charge
transfer
and
aggregation-induced
at
morphological
levels.
An
dye
emitting
up
1600
nm
quantum
yield
11.5%
NIR-II
region
is
developed.
fluorescence
blood
vessels
deeply-located
intestinal
tract
live
mice
based
on
dyes
achieved
high
clarity
enhanced
signal-to-background
ratio.
We
hope
this
study
will
inspire
further
development
evolution
bio-imaging.
