Advanced Materials,
Год журнала:
2020,
Номер
32(14)
Опубликована: Фев. 25, 2020
Abstract
Senescence
is
a
state
of
stable
cell
cycle
arrest
that
can
escape
apoptosis
and
lead
to
aging
numerous
age‐related
diseases.
In
this
study,
an
upconversion‐nanoparticle
(UCNP)‐centered
Au
20
–Au
30
nanoparticles
tetrahedron
(UAuTe)
prepared
by
DNA
hybridization,
which
selectively
accelerate
the
clearance
senescent
cells.
When
beta‐2‐microglobulin
antibody
(anti‐B2MG)
on
NPs
recognizes
cells,
application
near‐infrared
(NIR)
light
induces
disassembly
UAuTe
breaking
boronic
ester
linkage.
Subsequently,
Granzyme
B
exposed
UCNPs
in
then
be
tracked
changes
fluorescence.
It
found
that,
as
compared
single
B,
not
only
control
delivery
NIR‐responsivity,
but
also
synergistically
target
activate
without
need
perforin.
Moreover,
tool
applied
successfully
vivo;
results
demonstrate
NIR‐responsive
restore
renal
function,
tissue
homeostasis,
fur
density,
athletic
ability
mouse
model
senescence
after
d
treatment.
The
NIR‐induced
provides
practical
strategy
for
clinical
diagnosis
therapy,
particularly
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(8), С. 3939 - 3946
Опубликована: Янв. 23, 2020
Metal-organic
frameworks
(MOFs)
have
shown
great
potential
as
nanophotosensitizers
(nPSs)
for
photodynamic
therapy
(PDT).
The
use
of
such
MOFs
in
PDT,
however,
is
limited
by
the
shallow
depth
tissue
penetration
short-wavelength
light
and
oxygen-dependent
mechanism
that
renders
it
inadequate
hypoxic
tumors.
Here,
to
combat
limitations,
we
rationally
designed
core-shell
upconversion
nanoparticle@porphyrinic
(UCSs)
combinational
against
UCSs
were
synthesized
high
yield
through
conditional
surface
engineering
UCNPs
subsequent
seed-mediated
growth
strategy.
heterostructure
allows
efficient
energy
transfer
from
UCNP
core
MOF
shell,
which
enables
near-infrared
(NIR)
light-triggered
production
cytotoxic
reactive
oxygen
species.
A
hypoxia-activated
prodrug
tirapazamine
(TPZ)
was
encapsulated
nanopores
shell
heterostructures
final
construct
TPZ/UCSs.
We
demonstrated
TPZ/UCSs
represent
a
promising
system
achieving
improved
cancer
treatment
vitro
vivo
via
combination
NIR
light-induced
PDT
chemotherapy.
Furthermore,
integration
nanoplatform
with
antiprogrammed
death-ligand
1
(α-PD-L1)
promotes
abscopal
effect
completely
inhibit
untreated
distant
tumors
generating
specific
tumor
infiltration
T
cells.
Collectively,
this
work
highlights
robust
combining
chemotherapy
immunotherapy
current
limitations
treatment.
Advanced Functional Materials,
Год журнала:
2020,
Номер
30(13)
Опубликована: Фев. 14, 2020
Abstract
Sonodynamic
therapy
(SDT)
activated
by
ultrasound
is
attractive
as
a
potential
alternative
to
conventional
phototriggered
therapies
owing
the
deeper
penetration
depth
and
absence
of
phototoxicity.
Nevertheless,
low
quantum
yield
nano‐sonosensitizer
tumor
hypoxia
remain
significant
challenges
for
SDT.
Herein,
novel
TiO
2
‐based
reported
bilaterally
enhance
simultaneous
integration
precious
metal
Pt
nanoparticles
(NPs)
an
oxygen‐deficient
layer.
Furthermore,
hollow
cavity
serves
reservoir
load
doxorubicin,
anticancer
drug
chemotherapy
well
molecular
sonosensitizer
The
decorated
NPs
act
nanozymes
catalyze
decomposition
endogenous
hydrogen
peroxide
generation
oxygen
alleviate
hypoxia,
reduce
resistance
chemotherapy,
provide
sufficient
source
subsequently
facilitating
SDT‐induced
reactive
species
production.
high
chemo‐sonodynamic
synergistic
efficacy
systematically
demonstrated
both
in
vitro
vivo.
More
importantly,
it
believed
that
design
new
finding
synthesis
Pt–TiO
heterostructures
can
be
popularized
preparation
application
semiconductor‐based
nanoplatforms
many
fields.
Chemical Reviews,
Год журнала:
2021,
Номер
121(15), С. 9243 - 9358
Опубликована: Июль 20, 2021
Research
related
to
the
development
and
application
of
luminescent
nanoparticles
(LNPs)
for
chemical
biological
analysis
imaging
is
flourishing.
Novel
materials
new
applications
continue
be
reported
after
two
decades
research.
This
review
provides
a
comprehensive
heuristic
overview
this
field.
It
targeted
both
newcomers
experts
who
are
interested
in
critical
assessment
LNP
materials,
their
properties,
strengths
weaknesses,
prospective
applications.
Numerous
cataloged
by
fundamental
descriptions
identities
physical
morphology,
quantitative
photoluminescence
(PL)
PL
mechanisms,
surface
chemistry.
These
include
various
semiconductor
quantum
dots,
carbon
nanotubes,
graphene
derivatives,
nanodiamonds,
metal
nanoclusters,
lanthanide-doped
upconversion
downshifting
nanoparticles,
triplet–triplet
annihilation
persistent-luminescence
conjugated
polymer
semiconducting
multi-nanoparticle
assemblies,
doped
labeled
including
but
not
limited
those
based
on
polymers
silica.
As
an
exercise
these
ranked
several
application-related
functional
criteria.
Additional
sections
highlight
recent
examples
advances
analysis,
point-of-care
diagnostics,
cellular,
tissue,
vivo
theranostics.
drawn
from
literature
organized
material
particular
properties
that
leveraged
advantage.
Finally,
perspective
what
comes
next
field
offered.
Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(11), С. 4996 - 5001
Опубликована: Март 5, 2020
Exosomal
microRNAs
(miRNAs)
are
reliable
and
noninvasive
biomarkers
for
the
early
diagnosis
of
cancer.
Yet,
accurate
feasible
detection
exosomal
miRNAs
is
often
hampered
by
low
abundance
in
exosomes
requirement
RNA
extraction
large
sample
volumes.
Here
we
show
a
thermophoretic
sensor
implemented
with
nanoflares
situ
miRNAs,
without
resorting
to
either
or
target
amplification.
Thermophoretic
accumulation
nanoflare-treated
leads
an
amplified
fluorescence
signal
upon
binding
nanoflares,
allowing
direct
quantitative
measurement
down
0.36
fM
0.5
μL
serum
samples.
One
best
markers,
miR-375,
showed
accuracy
85%
estrogen
receptor-positive
breast
cancer
at
stages
(stages
I,
II).
This
work
provides
tool
improve
Chemical Reviews,
Год журнала:
2021,
Номер
121(17), С. 10469 - 10558
Опубликована: Июль 13, 2021
Nucleic
acids,
including
deoxyribonucleic
acid
(DNA)
and
ribonucleic
(RNA),
are
natural
biopolymers
composed
of
nucleotides
that
store,
transmit,
express
genetic
information.
Overexpressed
or
underexpressed
as
well
mutated
nucleic
acids
have
been
implicated
in
many
diseases.
Therefore,
tests
(NATs)
extremely
important.
Inspired
by
intracellular
DNA
replication
RNA
transcription,
vitro
NATs
extensively
developed
to
improve
the
detection
specificity,
sensitivity,
simplicity.
The
principles
can
be
general
classified
into
three
categories:
hybridization,
thermal-cycle
isothermal
amplification,
signal
amplification.
Driven
pressing
needs
clinical
diagnosis
prevention
infectious
diseases,
evolved
a
rapidly
advancing
field.
During
past
ten
years,
an
explosive
increase
research
interest
both
basic
translation
has
witnessed.
In
this
review,
we
aim
provide
comprehensive
coverage
progress
analyze
use
recognition
probes,
construct
devices
based
on
utilize
other
important
fields.
We
also
discuss
new
frontiers
field
challenges
addressed.
Journal of the American Chemical Society,
Год журнала:
2019,
Номер
141(49), С. 19373 - 19378
Опубликована: Ноя. 11, 2019
In
this
study,
a
hybrid
nanoassembly
consisting
of
an
upconversion
nanoparticle
(UCNP)
core
and
zeolitic
imidazolate
framework-8
(ZIF)
shell
encapsulated
with
chiral
NiSx
NPs
(denoted
as
UCNP@ZIF-NiSx)
were
fabricated.
The
UCNP@ZIF-NiSx
nanoassemblies
showed
intense
circular
dichroism
(CD)
signal
at
440
530
nm,
whereas
the
luminescence
(UCL)
UCNPs
540
nm
quenched
by
UCL
660
was
almost
unchanged.
By
taking
advantage
chiral-optical
fluorescent
signals,
dual
mode
can
be
used
for
quantitively
monitoring
reactive
oxygen
species
(ROS),
hydrogen
peroxide
(H2O2)
proof-of-concept
target
in
living
cells.
experimental
results
revealed
that
has
been
changed
into
UCNP@ZIF
degradation
during
detection
process.
Noticeably,
quantitative
selective
ROS
successfully
carried
out
vivo.
This
strategy
highlights
potential
detection,
which
opens
up
new
avenue
to
develop
toolbox
nanomaterials
biomedical
biological
analysis.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
60(16), С. 8923 - 8931
Опубликована: Янв. 22, 2021
Understanding
of
the
functions
enzymes
in
diverse
cellular
processes
is
important,
but
design
sensors
with
controllable
localization
for
situ
imaging
subcellular
levels
enzymatic
activity
particularly
challenging.
We
introduce
herein
a
spatiotemporally
controlled
sensor
technology
that
permits
and
photoactivated
human
apurinic/apyrimidinic
endonuclease
1
(APE1)
within
an
intracellular
organelle
choice
(e.g.,
mitochondria
or
nucleus).
The
hybrid
platform
constructed
by
photoactivatable
engineering
DNA-based
fluorescent
probe
further
combination
upconversion
nanoparticle
specific
signal.
Controlled
NIR-light-mediated
photoactivation
"on
demand"
effectively
constrains
signal
to
interest,
improved
resolution.
demonstrate
application
nanosensors
APE1
translocation
response
oxidative
stress
live
cells.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
60(33), С. 17937 - 17941
Опубликована: Июнь 12, 2021
Abstract
MicroRNA
(miRNA)
functions
are
tightly
regulated
by
their
sub‐compartmental
location
in
living
cells,
and
the
ability
to
imaging
of
mitochondrial
miRNAs
(mitomiRs)
is
essential
for
understanding
related
pathological
processes.
However,
most
existing
DNA‐based
methods
could
not
be
used
this
purpose.
Here,
we
report
development
a
DNA
nanoreporter
technology
mitomiRs
cells
through
near‐infrared
(NIR)
light‐controlled
strand
displacement
reactions.
The
sensing
function
nanoreporters
silent
(OFF)
during
delivery
process,
but
can
photoactivated
(ON)
with
NIR
light
after
targeted
localization,
enabling
spatially‐restricted
two
types
cancer‐related
improved
detection
accuracy.
Furthermore,
demonstrate
vivo
spatiotemporally‐controlled
activation.
Therefore,
study
illustrates
simple
methodology
that
may
broadly
applicable
investigating
mitomiRs‐associated
physiological
events.
