RSC Advances, Год журнала: 2025, Номер 15(7), С. 5167 - 5189
Опубликована: Янв. 1, 2025
The Mitsunobu reaction is a key bimolecular nucleophilic substitution for synthesizing chiral products. This paper highlights its importance in biologically active compounds, focusing on forming C–N single bonds.
Язык: Английский
Chemical Reviews, Год журнала: 2022, Номер 122(15), С. 12544 - 12747
Опубликована: Июль 17, 2022
1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating solvent that has found numerous uses in organic synthesis due to its ability stabilize ionic species, transfer protons, and engage range of other intermolecular interactions. The use this exponentially increased the past decade become choice some areas, such as C–H functionalization chemistry. In review, following brief history HFIP an overview physical properties, literature examples reactions using or additive are presented, emphasizing effect each reaction.
Язык: Английский
Процитировано
325
ACS Catalysis, Год журнала: 2023, Номер 13(14), С. 9442 - 9475
Опубликована: Июль 3, 2023
Spirocyclic indole derivatives are fascinating tridimensional molecular scaffolds from both a synthetic and biological point of view. Among the many strategies developed to access these structures, transition metal catalysis has recently led impressive advances, especially relying on unique reactivity dearomatized spirocyclic intermediates. These species can indeed evolve toward or nonspirocyclic products through rearomatization-driven processes, which at same time highly challenging control but also source large structural diversity. This review highlights most prominent methods past decade that involve spirocyclization tethered functional group may be activated by metal, leading rearomatized products. The discussion is particularly focused spiroindoleninium intermediate complex mechanistic features regarding its evolution, dependent catalytic systems.
Язык: Английский
Процитировано
44
European Journal of Organic Chemistry, Год журнала: 2021, Номер 2021(47), С. 6478 - 6510
Опубликована: Сен. 8, 2021
Abstract Current medicinal chemistry relies heavily on the quality of building blocks, i. e. reagents used to introduce chemical diversity into target molecules. The last decade witnessed an emergence many novel (or well‐overlooked old) chemotypes for drug discovery, which is related adapting new synthetic methodologies, designing sp 3 ‐enriched bioisosteres, paying attention previously underrated even unwanted) structural motifs, or combination thereof. In this review with 532 references, a survey selected that emerged recently in provided, focus synthesis corresponding blocks. Thus, saturated (hetero)aliphatic boronates, sulfonyl fluorides, sulfinates, non‐classical benzene isosteres, bicyclic morpholine/piperidine/piperazine analogs, as well gem ‐difluorinated cycloalkanes (as example emerging fluorinated motifs) are discussed.
Язык: Английский
Процитировано
96
Chemical Society Reviews, Год журнала: 2021, Номер 50(10), С. 5985 - 6012
Опубликована: Янв. 1, 2021
Pyrroloindolines are widely present in natural products. In this review, we summarize state-of-the-art of catalytic asymmetric synthesis pyrroloindolines, as well related applications to products total synthesis.
Язык: Английский
Процитировано
80
Seminars in Cancer Biology, Год журнала: 2021, Номер 86, С. 976 - 989
Опубликована: Март 18, 2021
Язык: Английский
Процитировано
62
Chemical Science, Год журнала: 2020, Номер 11(30), С. 7807 - 7812
Опубликована: Янв. 1, 2020
A
general,
practical,
and
efficient
synthesis
of
Язык: Английский
Процитировано
55
Tetrahedron Letters, Год журнала: 2021, Номер 71, С. 153029 - 153029
Опубликована: Март 27, 2021
Язык: Английский
Процитировано
48
Journal of the American Chemical Society, Год журнала: 2022, Номер 144(12), С. 5214 - 5225
Опубликована: Март 15, 2022
Achieving convergent synthetic strategies has long been a gold standard in constructing complex molecular skeletons, allowing for the rapid generation of complexity comparatively streamlined routes. Traditionally, biocatalysis not played prominent role laboratory synthesis, with application biocatalysts primarily limited to synthesis chiral fragments. Although use enzymes enable approaches is relatively new and emerging, combining efficiency transformations selectivity achievable through creates opportunities efficient strategies. This Perspective provides an overview recent developments biocatalytic offers insights into advantages these methods compared their small molecule-based counterparts.
Язык: Английский
Процитировано
38
Molecules, Год журнала: 2022, Номер 27(20), С. 6953 - 6953
Опубликована: Окт. 17, 2022
The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as significant for the interconversion of one functional group (alcohol) another (ester) presence oxidizing agents (azodicarboxylates) and reducing (phosphines). renowned stereoselective which inverts stereochemical configuration end products. One most important applications role synthesis natural This review article will focus on contribution towards total products, highlighting their biological potential during recent years.
Язык: Английский
Процитировано
38
Journal of the American Chemical Society, Год журнала: 2023, Номер 145(21), С. 11524 - 11529
Опубликована: Май 18, 2023
A method for C(sp
Язык: Английский
Процитировано
23