While
promising,
the
efficacy
of
aggregation-induced
emission
(AIE)-based
photodynamic
therapy
(PDT)
is
limited
by
several
factors
including
depth
laser
penetration
and
intratumoral
hypoxia.
In
present
study,
a
novel
bacteria-based
AIEgen
(TBP-2)
hybrid
system
(AE)
developed,
that
able
to
facilitate
hypoxia-tolerant
PDT
treatment
orthotopic
colon
tumors
via
an
interventional
method.
For
this
approach,
device
initially
designed,
composed
optical
fiber
endoscope,
allowing
for
clear
visualization
position
tumor
within
abdominal
cavity.
It
then
possible
conduct
successful
hypoxic
irradiation,
as
TBP-2
generate
hydroxyl
radicals
(•OH)
type
I
mechanism
microenvironment.
Moreover,
approach
proved
significantly
impair
cancer
growth
overcame
defects.
This
study
first
report
involving
such
strategy
knowledge,
it
has
potential
complement
other
modalities
while
also
highlighting
approaches
design
systems.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
60(23), С. 12971 - 12979
Опубликована: Март 27, 2021
Abstract
Photothermal
therapy
(PTT)
is
an
extremely
promising
tumor
therapeutic
modality.
However,
excessive
heat
inevitably
injures
normal
tissues
near
tumors,
and
the
damage
to
cancer
cells
caused
by
mild
hyperthermia
easily
repaired
stress‐induced
shock
proteins
(HSPs).
Thus,
maximizing
PTT
efficiency
minimizing
healthy
simultaneously
adopting
appropriate
temperatures
imperative.
Herein,
innovative
strategy
reported:
ferroptosis‐boosted
based
on
a
single‐atom
nanozyme
(SAzyme).
The
Pd
SAzyme
with
atom‐economical
utilization
of
catalytic
centers
exhibits
peroxidase
(POD)
glutathione
oxidase
(GSHOx)
mimicking
activities,
photothermal
conversion
performance,
which
can
result
in
ferroptosis
featuring
up‐regulation
lipid
peroxides
(LPO)
reactive
oxygen
species
(ROS).
accumulation
LPO
ROS
provides
powerful
approach
for
cleaving
HSPs,
enables
SAzyme‐mediated
mild‐temperature
PTT.
Phototherapy
such
as
photothermal
therapy
and
photodynamic
in
cancer
treatment
has
been
developed
quickly
over
the
past
few
years
for
its
noninvasive
nature
high
efficiency.
However,
there
are
still
many
drawbacks
phototherapy
that
prevent
it
from
clinical
applications.
Thus,
scientists
have
designed
different
systems
to
overcome
issues
associated
with
phototherapy,
including
enhancing
targeting
ability
of
low-temperature
therapy,
replacing
near-infrared
light
other
excitation
sources,
so
on.
This
article
discusses
problems
shortcomings
encountered
development
highlights
possible
solutions
address
them
may
become
a
useful
approach
practice.
aims
give
brief
summary
about
current
research
advancements
provides
quick
guideline
toward
future
developments
field.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(15), С. 8669 - 8742
Опубликована: Янв. 1, 2021
Inorganic
nanomaterials
that
have
inherently
exceptional
physicochemical
properties
(e.g.,
catalytic,
optical,
thermal,
electrical,
or
magnetic
performance)
can
provide
desirable
functionality
drug
delivery,
diagnostics,
imaging,
therapy)
considerable
potential
for
application
in
the
field
of
biomedicine.
However,
toxicity
be
caused
by
long-term,
non-specific
accumulation
these
inorganic
healthy
tissues,
preventing
their
large-scale
clinical
utilization.
Over
past
several
decades,
emergence
biodegradable
and
clearable
has
offered
to
prevent
such
long-term
toxicity.
In
addition,
a
comprehensive
understanding
design
metabolic
pathways
within
body
is
essential
enabling
expansion
theranostic
applications
various
diseases
advancing
trials.
Thus,
it
critical
importance
develop
biomedical
applications.
This
review
systematically
summarizes
recent
progress
nanomaterials,
particularly
cancer
theranostics
other
disease
therapies.
The
future
prospects
opportunities
this
rapidly
growing
are
also
discussed.
We
believe
timely
will
stimulate
guide
additional
in-depth
studies
area
nanomedicine,
as
rapid
vivo
clearance
degradation
likely
prerequisite
translation
with
unique
functionality.
Advanced Materials,
Год журнала:
2020,
Номер
32(43)
Опубликована: Сен. 18, 2020
Abstract
Rational
design
of
tumor
microenvironment
(TME)‐activated
nanocomposites
provides
an
innovative
strategy
to
construct
responsive
oncotherapy.
In
colorectal
cancer
(CRC),
the
specific
physiological
features
are
overexpressed
endogenous
H
2
S
and
slightly
acidic
microenvironment.
Here,
a
core–shell
Cu
O@CaCO
3
nanostructure
for
CRC
“turn‐on”
therapy
is
reported.
With
CaCO
pH
decomposition
O
sulfuration,
can
be
triggered
“on”
into
therapeutic
mode
by
TME.
When
shell
decomposes
releases
calcium
in
TME,
loss
protection
from
exposes
core
sulfuretted
form
metabolizable
31
16
nanocrystals
that
gain
remarkably
strong
near‐infrared
absorption.
After
modifying
hyaluronic
acid,
achieve
synergistic
CRC‐targeted
TME‐triggered
photothermal/photodynamic/chemodynamic/calcium‐overload‐mediated
therapy.
Moreover,
it
found
generation
hyperthermia
oxidative
stress
efficiently
reprogram
macrophages
M2
phenotype
M1
initiate
vaccine‐like
immune
effect
after
primary
removal,
which
further
induces
immune‐favorable
TME
intense
responses
anti‐CD47
antibody
simultaneously
inhibit
distant
metastasis
recurrence
immunotherapy.
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(32)
Опубликована: Июнь 10, 2021
Abstract
Non‐invasive
cancer
photothermal
therapy
(PTT)
is
a
promising
replacement
for
traditional
treatments.
The
second
near‐infrared
region
induced
PTT
(NIR‐II
PTT,
1000–1500
nm)
with
less
energy
dissipation
has
been
developed
deeper‐seated
tumor
treatment
in
recent
years
compared
the
first
light
(750–1000
nm).
In
addition,
use
of
emerging
inorganic
2D
nanomaterials
as
agents
(PTAs)
further
enhanced
efficiency
due
to
their
intrinsic
properties.
NIR‐II
stimulated
becoming
hot
topic
both
academic
and
clinical
fields.
This
review
summarizes
categories,
structures,
conversion
properties
time.
synergistic
strategies
responsive
combined
other
approaches
including
chemotherapy,
chemodynamic
therapy,
photodynamic
radiotherapy
are
summarized.
future
challenges
perspectives
on
these
systems
construction
discussed.
Multifunctional
nanoplatforms
for
imaging-guided
synergistic
antitumor
treatment
are
highly
desirable
in
biomedical
applications.
However,
anticancer
is
largely
affected
by
the
pre-existing
hypoxic
tumor
microenvironment
(TME),
which
not
only
causes
resistance
of
tumors
to
photodynamic
therapy
(PDT),
but
also
promotes
tumorigenesis
and
progression.
Here,
a
continuous
O
