While
promising,
the
efficacy
of
aggregation-induced
emission
(AIE)-based
photodynamic
therapy
(PDT)
is
limited
by
several
factors
including
depth
laser
penetration
and
intratumoral
hypoxia.
In
present
study,
a
novel
bacteria-based
AIEgen
(TBP-2)
hybrid
system
(AE)
developed,
that
able
to
facilitate
hypoxia-tolerant
PDT
treatment
orthotopic
colon
tumors
via
an
interventional
method.
For
this
approach,
device
initially
designed,
composed
optical
fiber
endoscope,
allowing
for
clear
visualization
position
tumor
within
abdominal
cavity.
It
then
possible
conduct
successful
hypoxic
irradiation,
as
TBP-2
generate
hydroxyl
radicals
(•OH)
type
I
mechanism
microenvironment.
Moreover,
approach
proved
significantly
impair
cancer
growth
overcame
defects.
This
study
first
report
involving
such
strategy
knowledge,
it
has
potential
complement
other
modalities
while
also
highlighting
approaches
design
systems.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Ноя. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(24)
Опубликована: Апрель 26, 2023
Photodynamic
therapy
(PDT),
with
its
advantages
of
high
targeting,
minimally
invasive,
and
low
toxicity
side
effects,
has
been
widely
used
in
the
clinical
various
tumors,
especially
superficial
tumors.
However,
tumor
microenvironment
(TME)
presents
hypoxia
due
to
oxygen
(O2
)
supply
caused
by
abnormal
vascularization
neoplastic
tissues
O2
consumption
induced
rapid
proliferation
cells.
The
efficacy
oxygen-consumping
PDT
can
be
hampered
a
hypoxic
TME.
To
address
this
problem,
researchers
have
developing
advanced
nanoplatforms
strategies
enhance
therapeutic
effect
treatment.
This
review
summarizes
recent
against
TME,
thus
enhancing
efficacy,
including
increasing
content
TME
through
delivering
tumors
situ
generations
;
decreasing
during
design
type
I
photosensitizers.
Moreover,
synergistically
combined
other
methods
such
as
chemotherapy,
photothermal
therapy,
immunotherapy,
gas
is
accounted
for
addressing
challenging
problems
mono
environments,
resistance,
proliferation,
metastasis.
Finally,
perspectives
opportunities
challenges
future
research
translations
are
provided.
Chemical Society Reviews,
Год журнала:
2022,
Номер
51(9), С. 3688 - 3734
Опубликована: Янв. 1, 2022
Due
to
inherent
structural
defects,
common
nanocatalysts
always
display
limited
catalytic
activity
and
selectivity,
making
it
practically
difficult
for
them
replace
natural
enzymes
in
a
broad
scope
of
biologically
important
applications.
By
decreasing
the
size
nanocatalysts,
their
selectivity
will
be
substantially
improved.
Guided
by
this
concept,
advances
now
enter
an
era
atomic-level
precise
control.
Single-atom
catalysts
(denoted
as
SACs),
characterized
atomically
dispersed
active
sites,
strikingly
show
utmost
atomic
utilization,
precisely
located
metal
centers,
unique
metal-support
interactions
identical
coordination
environments.
Such
advantages
SACs
drastically
boost
specific
per
atom,
thus
provide
great
potential
achieving
superior
functionally
mimic
or
even
outperform
interest.
Although
does
matter,
is
not
clear
whether
guideline
"the
smaller,
better"
still
correct
developing
at
single-atom
scale.
Thus,
clearly
new,
urgent
issue
address
before
further
extending
into
biomedical
applications,
representing
branch
nanomedicine.
This
review
begins
providing
overview
recent
synthesis
strategies
SACs,
which
serve
basis
discussion
emerging
achievements
improving
enzyme-like
properties
level.
Then,
we
carefully
compare
structures
functions
various
scales
from
nanoparticles,
nanoclusters,
few-atom
clusters
single
atoms.
Contrary
conventional
wisdom,
are
most
catalytically
reactions,
especially
those
requiring
multi-site
auxiliary
activities.
After
that,
highlight
roles
toward
To
appreciate
these
advances,
challenges
prospects
rapidly
growing
studies
SACs-related
nanomedicine
also
discussed
review.
Materials,
Год журнала:
2023,
Номер
16(15), С. 5354 - 5354
Опубликована: Июль 30, 2023
The
use
of
tailored
medication
delivery
in
cancer
treatment
has
the
potential
to
increase
efficacy
while
decreasing
unfavourable
side
effects.
For
researchers
looking
improve
clinical
outcomes,
chemotherapy
for
continues
be
most
challenging
topic.
Cancer
is
one
worst
illnesses
despite
limits
current
therapies.
New
anticancer
medications
are
therefore
required
treat
cancer.
Nanotechnology
revolutionized
medical
research
with
new
and
improved
materials
biomedical
applications,
a
particular
focus
on
therapy
diagnostics.
In
research,
application
metal
nanoparticles
as
substitute
drugs
growing.
Metals
exhibit
inherent
or
surface-induced
properties,
making
metallic
extremely
useful.
development
proceeding
rapidly
many
directions,
offering
alternative
therapeutic
strategies
improving
outcomes
treatments.
This
review
aimed
present
commonly
used
applications.
Abstract
Phototherapy,
mainly
including
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
can
kill
cancer
cells
by
generating
heat
or
reactive
oxygen
species,
which
has
the
advantages
of
being
minimally
invasive,
high
efficiency,
low
toxicity.
However,
traditional
phototherapeutic
agents
face
challenges
such
as
poor
tumor
targeting,
susceptibility
to
passive
immune
clearance,
suboptimal
biocompatibility,
limit
their
clinical
application.
Recently,
cell
membrane
biomimetic
technology
endows
with
unique
biological
functions,
promoted
escape,
prolonged
in
vivo
circulation
time,
improved
enhanced
anti‐tumor
efficacy.
In
addition,
phototherapy
mediated
(CCM)
membrane‐modified
promote
broad
immunity.
this
review,
we
deeply
analyze
mechanisms
PTT
PDT,
systematically
discuss
synthesis
strategies
functions
nanomaterials,
focus
on
progress
based
nanomaterials
synergistic
therapies
chemotherapy,
radiotherapy,
immunotherapy,
sonodynamic
therapy.
Finally,
address
opportunities
future
prospects
field
phototherapy.
This
comprehensive
review
is
expected
provide
insights
into
promoting
translation
agents.
Abstract
Recently,
variable
nanocatalysts
have
provided
novel,
highly
selective,
minimally
invasive
strategies
driven
by
external
physical
fields
for
cancer
therapy.
In
the
catalytic
reaction,
less
toxic
or
nontoxic
substances
can
be
in
situ
converted
into
agents
suppression.
this
review,
we
systematically
summarize
therapy
based
on
different
types
of
fields,
including
light,
ultrasound,
electricity,
temperature,
X‐ray,
magnetic
field,
and
microwave.
The
properties,
mechanisms,
advantages
corresponding
are
also
introduced.
Importantly,
considering
rapid
development
nanomedicine,
research
progress
is
discussed.
Finally,
remaining
challenges
outlooks
that
faced
outlined.
We
believe
emerging
fields‐driven
nanocatalytic
will
provide
a
new
avenue
treatment.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(29)
Опубликована: Фев. 13, 2024
Abstract
Defect
engineering
is
an
emerging
technology
for
tailoring
nanomaterials'
characteristics
and
catalytic
performance
in
various
applications.
Recently,
defect‐engineered
nanoparticles
have
emerged
as
highly
researched
materials
applications
because
of
their
exceptional
redox
reaction
capabilities
physicochemical
optical
properties.
The
properties
nanomaterials
can
be
readily
adjusted
by
controlling
the
nature
concentration
defects
within
nanoparticles,
avoiding
need
intricate
design
strategies.
This
review
investigates
defect
nanocatalysts,
including
design,
fabrication,
Initially,
categories
strategies
nanomaterial
impacts
on
nanocatalysts'
electronic
surface
properties,
activity,
selectivity,
stability
are
summarized.
Then,
processes
uses,
gas
sensing,
hydrogen
(H
2
)
evolutions,
water
splitting,
reductions
carbon
dioxide
(CO
nitrogen
to
value‐aided
products,
pollutant
degradation,
biomedical
(oncotherapy,
antibacterial
wound
healing,
biomolecular
sensing)
discussed.
Finally,
limitations
prospective
paths
allowing
logical
optimization
nanocatalytic
long‐term
efficient
also
examined.
comprehensive
gives
unique
insights
into
current
state
nanocatalysts
inspires
future
research
exploiting
shortcomings
improve
customize
performance.
