International Journal of Pharmaceutics, Год журнала: 2024, Номер 656, С. 124095 - 124095
Опубликована: Апрель 6, 2024
Язык: Английский
Carbohydrate Polymers, Год журнала: 2023, Номер 316, С. 121024 - 121024
Опубликована: Май 18, 2023
Язык: Английский
Процитировано
55
Chemical Engineering Journal, Год журнала: 2024, Номер 487, С. 150403 - 150403
Опубликована: Март 16, 2024
Hydrogels have emerged in various biomedical applications, including tissue engineering and medical devices, due to their ability imitate the natural extracellular matrix (ECM) of tissues. However, conventional static hydrogels lack dynamically respond changes surroundings withstand robust biophysical microenvironment trigger on-demand functionality such as drug release mechanical change. In contrast, multifunctional dynamic can adapt external stimuli drawn great attention recent studies. It is realized that integration nanomaterials into provides numerous functionalities for a variety applications cannot be achieved by hydrogels. This review article comprehensive overview advances designing fabricating applications. We describe different types based on breakable reversible covalent bonds well noncovalent interactions. These mechanisms are described detail useful reference crosslinking strategies strongly influence properties also discuss use potential benefits. further explores nanocomposite hydrogels, delivery, engineering, bioadhesives, wound healing, cancer treatment, mechanistic study, multiple-scale Finally, we challenges future perspectives field diverse technologies.
Язык: Английский
Процитировано
37
Advanced Functional Materials, Год журнала: 2024, Номер 34(38)
Опубликована: Апрель 23, 2024
Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.
Язык: Английский
Процитировано
36
Chemical Engineering Journal, Год журнала: 2024, Номер 495, С. 153640 - 153640
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
33
Biomaterials, Год журнала: 2024, Номер 311, С. 122690 - 122690
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
27
Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)
Опубликована: Май 27, 2024
Infected wounds pose challenges such as exudate management, bacterial infections, and persistent inflammation, making them a significant challenge for modern dressings. To address these issues in infected more effectively, aerogel-hydrogel biphase gels based on dextran are developed. The gel introduced this study exhibits antibacterial anti-inflammatory properties the process of wound therapy, contributing to accelerated healing. aerogel phase exceptional water-absorption capabilities, rapidly soaking up from wound, thereby fostering clean hygienic healing microenvironment. Concurrently, is enriched with hydrogen sulfide donors. Following water absorption formation hydrogel phase, it enables sustained release around sites. experiments confirm that sulfide, by promoting M2 macrophage differentiation reducing levels inflammatory factors, effectively diminishes local inflammation at site. Furthermore, sodium copper chlorophyllin component within demonstrates effective through photodynamic antimicrobial providing viable solution infection challenges.
Язык: Английский
Процитировано
24
Biomacromolecules, Год журнала: 2024, Номер 25(2), С. 819 - 828
Опубликована: Янв. 22, 2024
The combinational properties with excellent mechanical properties, adhesive performance, hemostatic ability, antibacterial action, and wound healing efficacy are highly desirable for injectable hydrogels' practical applications in hemorrhage control closure, but designing one single hydrogel system integrating such is still difficult. Herein, a simplified yet straightforward strategy proposed to prepare an robust poly(N,N-dimethylacrylamide) (PDMAA)/carboxymethyl chitosan (CMCS) induced by tranexamic acid (TXA). TXA not only promotes the rapid generation of free radicals also introduces multiple hydrogen bonds into network. Moreover, as common clinical drug, itself has effects. In addition, CMCS imparts sterilization hemostasis effects hydrogel, thereby promoting healing. Besides, amino carboxyl groups on molecules hydroxyl, amino, can form wet biological tissues, leading good tissue adhesion hydrogel. As result, (up 1.83 MPa at 90% compression strain), performance 18.7 kPa strength porcine skin tissue), biocompatibility, activity, be fabricated within several minutes. These advantages enable efficiently stop (blood loss amount: 110 mg; time: 25 s) promote process (wound closure rate 2 weeks: 83%), which verified using rat models liver bleeding infected full thickness defect. Overall, this facile design incorporating unique will greatly advance hydrogel's application
Язык: Английский
Процитировано
20
Biomaterials, Год журнала: 2025, Номер unknown, С. 123134 - 123134
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
5
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Biofilms play a pivotal role in bacterial pathogenicity and antibiotic resistance, representing major challenge the treatment of infections. The limited diffusion inactivation efficacy antibiotics within biofilms hinder their clearance, while increasing dosage may enhance effectiveness, it also promotes resistance. Nano-delivery systems that target antimicrobial agents directly to offer promising strategy overcome this challenge. This review summarizes resistance mechanisms therapeutic challenges associated with biofilms, focus on recent advances nano-delivery such as liposomes, nanoemulsions, cell membrane vesicles (CMVs), polymers, dendrimers, nanogels, inorganic nanoparticles, metal-organic frameworks (MOFs). Furthermore, explores potential applications biofilm provides recommendations guide future research development field.
Язык: Английский
Процитировано
4
Acta Biomaterialia, Год журнала: 2023, Номер 170, С. 389 - 400
Опубликована: Авг. 23, 2023
Язык: Английский
Процитировано
30