Journal of the American Chemical Society,
Год журнала:
2021,
Номер
143(19), С. 7541 - 7552
Опубликована: Май 11, 2021
Phototheranostics
constitute
an
emerging
cancer
treatment
wherein
the
core
diagnostic
and
therapeutic
functions
are
integrated
into
a
single
photosensitizer
(PS).
Achieving
full
potential
of
this
modality
requires
being
able
to
tune
photosensitizing
properties
PS
in
question.
Structural
modification
organic
framework
represents
time-honored
strategy
for
tuning
photophysical
features
given
system.
Here
we
report
easy-to-implement
metal
selection
approach
that
allows
fine-tuning
excited-state
energy
dissipation
phototheranostics
as
exemplified
by
set
lanthanide
(Ln
=
Gd,
Yb,
Er)
carbazole-containing
porphyrinoid
complexes.
Femto-
nanosecond
time-resolved
spectroscopic
studies,
conjunction
with
density
functional
theory
calculations,
revealed
pathways
PSs
highly
dependent
on
gap
between
lowest
triplet
excited
state
ligand
states
coordinated
Ln
ions.
The
Yb
complex
displayed
balance
deactivation
mechanisms
made
it
attractive
combined
photoacoustic
imaging
photothermal/photodynamic
therapy
agent.
It
was
encapsulated
mesoporous
silica
nanoparticles
(MSN)
provide
biocompatible
construct,
YbL@MSN,
which
displays
high
photothermal
conversion
efficiency
(η
45%)
decent
singlet
oxygen
quantum
yield
(ΦΔ
31%).
Mouse
model
studies
YbL@MSN
both
synergistic
photothermal-
photodynamic-therapy-based
tumor
reduction
vivo.
Our
results
lead
us
suggest
promising
phototheranostics.
Chemical Reviews,
Год журнала:
2021,
Номер
121(21), С. 13454 - 13619
Опубликована: Сен. 28, 2021
This
review
presents
a
robust
strategy
to
design
photosensitizers
(PSs)
for
various
species.
Photodynamic
therapy
(PDT)
is
photochemical-based
treatment
approach
that
involves
the
use
of
light
combined
with
light-activated
chemical,
referred
as
PS.
Attractively,
PDT
one
alternatives
conventional
cancer
due
its
noninvasive
nature,
high
cure
rates,
and
low
side
effects.
PSs
play
an
important
factor
in
photoinduced
reactive
oxygen
species
(ROS)
generation.
Although
concept
photosensitizer-based
photodynamic
has
been
widely
adopted
clinical
trials
bioimaging,
until
now,
our
surprise,
there
no
relevant
article
on
rational
designs
organic
PDT.
Furthermore,
most
published
articles
focused
nanomaterials
nanotechnology
based
traditional
PSs.
Therefore,
this
aimed
at
reporting
recent
strategies
develop
innovative
enhanced
therapy,
each
example
described
detail
instead
providing
only
general
overview,
typically
done
previous
reviews
PDT,
provide
intuitive,
vivid,
specific
insights
readers.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
61(5)
Опубликована: Ноя. 8, 2021
Cancer
has
emerged
over
the
last
decades
as
one
of
deadliest
diseases
in
world.
Among
most
commonly
used
techniques
(i.e.
surgery,
immunotherapy,
radiotherapy
or
chemotherapy),
increasing
attention
been
devoted
towards
photodynamic
therapy.
However,
vast
majority
clinically
applied
photosensitizers
are
not
ideal
and
associated
with
several
limitations
including
poor
aqueous
solubility,
photostability
slow
clearance
from
body,
causing
photosensitivity.
In
an
effort
to
overcome
these
drawbacks,
much
incorporation
a
metal
ion.
Herein,
clinical
development
metal-containing
compounds
Purlytin
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Июнь 26, 2020
The
use
of
photodynamic
therapy
(PDT)
against
cancer
has
received
increasing
attention
over
recent
years.
However,
the
application
currently
approved
photosensitizers
(PSs)
is
limited
by
their
poor
aqueous
solubility,
aggregation,
photobleaching
and
slow
clearance
from
body.
To
overcome
these
limitations,
there
a
need
for
development
new
classes
PSs
with
ruthenium(II)
polypyridine
complexes
gaining
momentum.
compounds
generally
lack
significant
absorption
in
biological
spectral
window,
limiting
to
treat
deep-seated
or
large
tumors.
this
drawback,
designed
silico
(E,E')-4,4'-bisstyryl-2,2'-bipyridine
ligands
show
impressive
1-
2-Photon
up
magnitude
higher
than
ones
published
so
far.
While
nontoxic
dark,
are
phototoxic
various
2D
monolayer
cells,
3D
multicellular
tumor
spheroids
able
eradicate
multiresistant
inside
mouse
model
upon
clinically
relevant
1-Photon
excitation.
Angewandte Chemie International Edition,
Год журнала:
2021,
Номер
61(8)
Опубликована: Ноя. 29, 2021
An
ideal
cancer
treatment
should
not
only
destroy
primary
tumors
but
also
improve
the
immunogenicity
of
tumor
microenvironment
to
achieve
a
satisfactory
anti-tumor
immune
effect.
We
designed
carbonic
anhydrase
IX
(CAIX)-anchored
rhenium(I)
photosensitizer,
named
CA-Re,
that
performs
type-I
and
type-II
photodynamic
therapy
(PDT)
with
high
efficiency
under
hypoxia
(nanomolar-level
phototoxicity),
evokes
gasdermin
D
(GSDMD)
mediated
pyroptotic
cell
death
effectively
stimulate
immunogenicity.
CA-Re
could
disrupt
self-report
loss
membrane
integrity
simultaneously.
This
promoted
maturation
antigen-presenting
ability
dendritic
cells
(DCs),
fully
activated
T
dependent
adaptive
response
in
vivo,
eventually
eliminating
distant
at
same
time
as
destroying
tumors.
To
best
our
knowledge,
is
first
metal
complex-based
pyroptosis
inducer.
Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(32), С. 14420 - 14440
Опубликована: Авг. 4, 2022
There
has
been
emerging
interest
in
the
exploitation
of
photophysical
and
photochemical
properties
transition
metal
complexes
for
diagnostic
therapeutic
applications.
In
this
Perspective,
we
highlight
major
recent
advances
development
luminescent
photofunctional
complexes,
particular,
those
rhenium(I),
ruthenium(II),
osmium(II),
iridium(III),
platinum(II),
as
bioimaging
reagents
phototherapeutic
agents,
with
a
focus
on
molecular
design
strategies
that
harness
modulate
interesting
behavior
complexes.
We
also
discuss
current
challenges
future
outlook
both
fundamental
research
clinical
Chemical Reviews,
Год журнала:
2021,
Номер
122(2), С. 1752 - 1829
Опубликована: Сен. 21, 2021
Chemically
modified
biomacromolecules─i.e.,
proteins,
nucleic
acids,
glycans,
and
lipids─have
become
crucial
tools
in
chemical
biology.
They
are
extensively
used
not
only
to
elucidate
cellular
processes
but
also
industrial
applications,
particularly
the
context
of
biopharmaceuticals.
In
order
enable
maximum
scope
for
optimization,
it
is
pivotal
have
a
diverse
array
biomacromolecule
modification
methods
at
one's
disposal.
Chemistry
has
driven
many
significant
advances
this
area,
especially
recently,
numerous
novel
visible-light-induced
photochemical
approaches
emerged.
these
reactions,
light
serves
as
an
external
source
energy,
enabling
access
highly
reactive
intermediates
under
exceedingly
mild
conditions
with
exquisite
spatiotemporal
control.
While
UV-induced
transformations
on
biomacromolecules
date
back
decades,
visible
unmistakable
advantage
being
considerably
more
biocompatible,
spectrum
visible-light-driven
now
available,
chiefly
proteins
acids.
This
review
will
discuss
modifications
native
functional
groups
(FGs),
including
functionalization,
labeling,
cross-linking
techniques
well
utility
oxidative
degradation
mediated
by
photochemically
generated
oxygen
species.
Furthermore,
non-native,
bioorthogonal
FGs
be
addressed,
photoclick
chemistry
DNA-encoded
library
synthesis
that
allow
manipulation
activity
biomacromolecule.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Июнь 2, 2022
Effective
photosensitizers
are
of
particular
importance
for
the
widespread
clinical
utilization
phototherapy.
However,
conventional
usually
plagued
by
short-wavelength
absorption,
inadequate
photostability,
low
reactive
oxygen
species
(ROS)
quantum
yields,
and
aggregation-caused
ROS
quenching.
Here,
we
report
a
near-infrared
(NIR)-supramolecular
photosensitizer
(RuDA)
via
self-assembly
an
organometallic
Ru(II)-arene
complex
in
aqueous
solution.
RuDA
can
generate
singlet
(1O2)
only
aggregate
state,
showing
distinct
aggregation-induced
1O2
generation
behavior
due
to
greatly
increased
singlet-triplet
intersystem
crossing
process.
Upon
808
nm
laser
irradiation,
with
excellent
photostability
displays
efficient
heat
yield
16.4%
(FDA-approved
indocyanine
green:
ΦΔ
=
0.2%)
together
high
photothermal
conversion
efficiency
24.2%
(commercial
gold
nanorods:
21.0%,
nanoshells:
13.0%).
In
addition,
RuDA-NPs
good
biocompatibility
be
preferably
accumulated
at
tumor
sites,
inducing
significant
regression
95.2%
volume
reduction
vivo
during
photodynamic
therapy.
This
aggregation
enhanced
therapy
provides
strategy
design
promising
photophysical
photochemical
characteristics.
Nature Communications,
Год журнала:
2021,
Номер
12(1)
Опубликована: Авг. 18, 2021
Abstract
As
a
basic
structure
of
most
polypyridinal
metal
complexes,
[Ru(bpy)
3
]
2+
,
has
the
advantages
simple
structure,
facile
synthesis
and
high
yield,
which
great
potential
for
scientific
research
application.
However,
sonodynamic
therapy
(SDT)
performance
not
been
investigated
so
far.
SDT
can
overcome
tissue-penetration
phototoxicity
problems
compared
to
photodynamic
therapy.
Here,
we
report
that
is
highly
potent
sonosensitizer
sonocatalyst
sonotherapy
in
vitro
vivo.
produce
singlet
oxygen
(
1
O
2
)
sono-oxidize
endogenous
1,4-dihydronicotinamide
adenine
dinucleotide
(NADH)
under
ultrasound
(US)
stimulation
cancer
cells.
Furthermore,
enables
effective
destruction
mice
tumors,
therapeutic
effect
reach
deep
tissues
over
10
cm
US
irradiation.
This
work
paves
way
complexes
be
applied
noninvasive
precise
cancer.
