Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome

Journal of Exposure Science & Environmental Epidemiology, Год журнала: 2023, Номер 33(4), С. 524 - 536

Опубликована: Июнь 28, 2023

Non-targeted analysis (NTA) and suspect screening (SSA) are powerful techniques that rely on high-resolution mass spectrometry (HRMS) computational tools to detect identify unknown or suspected chemicals in the exposome. Fully understanding chemical exposome requires characterization of both environmental media human specimens. As such, we conducted a review examine use different NTA SSA methods various exposure samples, including results detected. The literature was by searching databases, such as PubMed Web Science, for keywords, "non-targeted analysis", "suspect analysis" media. Sources discussed this include water, air, soil/sediment, dust, food consumer products. discovery biospecimen is also reviewed. space has been captured using varies analyzed analytical platform. In each were frequently detected were: per- polyfluoroalkyl substances (PFAS) pharmaceuticals pesticides polyaromatic hydrocarbons (PAHs) soil sediment, volatile semi-volatile organic compounds flame retardants plasticizers products, plasticizers, pesticides, halogenated samples. Some studies reviewed herein used liquid chromatography (LC) gas (GC) HRMS increase (16%); however, majority (51%) only LC-HRMS fewer GC-HRMS (32%). Finally, knowledge technology gaps must be overcome fully assess potential exposures NTA. Understanding essential identifying prioritizing our sources prior exposures. IMPACT STATEMENT: This examines analyzing samples based non-targeted (SSA).

Язык: Английский

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Comprehensive chemical characterization of gaseous I/SVOC emissions from heavy-duty diesel vehicles using two-dimensional gas chromatography time-of-flight mass spectrometry

Environmental Pollution, Год журнала: 2022, Номер 305, С. 119284 - 119284

Опубликована: Апрель 15, 2022

Язык: Английский

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Performance and mechanism of bamboo residues pyrolysis: Gas emissions, by-products, and reaction kinetics

The Science of The Total Environment, Год журнала: 2022, Номер 838, С. 156560 - 156560

Опубликована: Июнь 8, 2022

Язык: Английский

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Non-target scanning of organics from cooking emissions using comprehensive two-dimensional gas chromatography-mass spectrometer (GC×GC-MS)

Applied Geochemistry, Год журнала: 2023, Номер 151, С. 105601 - 105601

Опубликована: Фев. 16, 2023

Язык: Английский

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Impact of cooking style and oil on semi-volatile and intermediate volatility organic compound emissions from Chinese domestic cooking

Atmospheric chemistry and physics, Год журнала: 2022, Номер 22(15), С. 9827 - 9841

Опубликована: Авг. 2, 2022

Abstract. To elucidate the molecular chemical compositions, volatility–polarity distributions, and influencing factors of Chinese cooking emissions, a comprehensive emission experiment was conducted. Volatile organic compounds (VOCs), intermediate volatility, semi-volatile (I/SVOCs) from fumes were analysed by thermal desorption two-dimensional gas chromatography coupled with quadrupole mass spectrometer (TD-GC × GC-qMS). Emissions four typical dishes, i.e. fried chicken, Kung Pao pan-fried tofu, stir-fried cabbage investigated to illustrate impact style material. Fumes chicken corn, peanut, soybean, sunflower oils demonstrate influence oil. A total 201 chemicals quantified. emitted more pollutants than other dishes due its rather intense method. Aromatics oxygenated extensively detected among meat-related fumes, while vegetable-related profile observed in emissions cabbage. Ozone formation potential (OFP) dominated VOC range. Of secondary aerosol (SOA) estimation, 10.2 %–32.0 % could be explained S/IVOCs. Pixel-based partial least squares discriminant analysis (PLS-DA) multiway principal component (MPCA) utilized for sample classification identification. The results indicated that oil factor variance compositions factor. MPCA emphasize importance unsaturated fatty acid-alkadienal-volatile products mechanism (oil autoxidation) accelerated heating procedure.

Язык: Английский

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Investigation of partition coefficients and fingerprints of atmospheric gas- and particle-phase intermediate volatility and semi-volatile organic compounds using pixel-based approaches

Journal of Chromatography A, Год журнала: 2022, Номер 1665, С. 462808 - 462808

Опубликована: Янв. 7, 2022

Язык: Английский

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Higher Toxicity of Gaseous Organics Relative to Particulate Matters Emitted from Typical Cooking Processes

Environmental Science & Technology, Год журнала: 2023, Номер 57(44), С. 17022 - 17031

Опубликована: Окт. 24, 2023

Cooking emission is known to be a significant anthropogenic source of air pollution in urban areas, but its toxicities are still unclear. This study addressed the fine particulate matter (PM2.5) and gaseous organics by combining chemical fingerprinting analysis with cellular assessments. The cytotoxicity reactive oxygen species activity were ∼1.9 ∼8.3 times higher than those PM2.5, respectively. Moreover, these values per unit mass PM2.5 ∼7.1 ∼15.7 collected from ambient Shanghai. total oleic acid equivalent quantities for carcinogenic toxic respiratory effects organics, as estimated using predictive models based on quantitative structure-property relationships, 1686 ± 803 430 176 μg/mg Both predicted consistent assessment. These health risks primarily attributed high relative content equivalency factor organic compounds present gas phase, including 7,9-di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, 2-ethylhexanoic acid, 2-phenoxyethoxybenzene. Furthermore, fatty acids identified prominent markers cooking-related emissions. obtained results highlight importance control measures cooking-emitted reduce personal exposure risks.

Язык: Английский

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Application of optical diagnosis technology in biomass combustion

Biomass and Bioenergy, Год журнала: 2024, Номер 184, С. 107198 - 107198

Опубликована: Март 27, 2024

Язык: Английский

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Obscured Contribution of Oxygenated Intermediate-Volatility Organic Compounds to Secondary Organic Aerosol Formation from Gasoline Vehicle Emissions

Environmental Science & Technology, Год журнала: 2024, Номер 58(24), С. 10652 - 10663

Опубликована: Июнь 3, 2024

Secondary organic aerosol (SOA) formation from gasoline vehicles spanning a wide range of emission types was investigated using an oxidation flow reactor (OFR) by conducting chassis dynamometer tests. Aided advanced mass spectrometric techniques, SOA precursors, including volatile compounds (VOCs) and intermediate/semivolatile (I/SVOCs), were comprehensively characterized. The reconstructed produced the speciated VOCs I/SVOCs can explain 69% measured downstream OFR upon 0.5–3 days' OH exposure. While only 10% total production, contribution is 59%, with oxygenated (O–I/SVOCs) taking up 20% that contribution. O–I/SVOCs (e.g., benzylic or aliphatic aldehydes ketones), as obscured source, account for 16% nonmethane gas (NMOG) emission. More importantly, improvement in standards, NMOG effectively mitigated 35% China 4 to 6, which predominantly attributed decrease VOCs. Real-time measurements different components well production further reveal current control measures, such advances engine three-way catalytic converter (TWC) are effective reducing "light" precursors (i.e., single-ring aromatics) but not I/SVOC emissions. Our results also highlight greater effects than previously observed urgent need investigation into their origins, i.e., incomplete combustion, lubricating oil, etc., requires improvements real-time molecular-level characterization molecules turn will benefit future design measures.

Язык: Английский

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Incomplete solid fuel burning as the major emission source of atmospheric phenols and environmentally persistent free radicals

Fuel, Год журнала: 2024, Номер 369, С. 131735 - 131735

Опубликована: Апрель 21, 2024

Язык: Английский

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