Impacts of Prediabetes Mellitus Alone or Plus Hypertension on the Coronary Severity and Cardiovascular Outcomes

Hypertension, Год журнала: 2018, Номер 71(6), С. 1039 - 1046

Опубликована: Апрель 18, 2018

Whether prediabetes mellitus (Pre-DM) alone or combined with hypertension is an independent risk factor for cardiovascular disease has not been fully clarified. This study aimed to further confirm whether the relation of Pre-DM differs between individuals without hypertension. A total 7121 consecutive patients angina-like chest pain who received coronary angiography were evaluated and 4193 angiography-proven stable, new-onset artery enrolled into study. They divided 3 groups according diabetes status stratified by The severity was assessed number diseased vessels Gensini score. All subjects regularly followed up occurrence composite end points. Comparisons outcomes performed among these groups. During average 11 338 patient-years follow-up, 434 (10.35%) events occurred. No significant difference observed in point normal glucose regulation (both P>0.05). However, when also incorporated as a stratifying factor, risk, clinical prognosis, significantly elevated plus groups, compared reference group blood pressure (all P<0.05). present indicated that disease, increased largely driven coexistence rather than per se.

Язык: Английский

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<p>Hypertension and Its Associated Factors Among Type 2 Diabetes Mellitus Patients at Debre Tabor General Hospital, Northwest Ethiopia</p>

Diabetes Metabolic Syndrome and Obesity, Год журнала: 2020, Номер Volume 13, С. 1621 - 1631

Опубликована: Май 1, 2020

Background: Type 2 diabetes mellitus (T2DM) is associated with a high risk of early mortality and morbidity from hypertension. Even though Ethiopia Africa's first country among the top five in prevalence DM, there paucity data on hypertension its factors patients type mellitus. Therefore, this study aimed to determine at Debre Tabor General Hospital, 2019. Methods Materials: An institution-based cross-sectional was employed 378 T2DM patients. Data were collected using an interviewer-administered questionnaire analyzed by Stata 14. A multivariable logistic regression model used identify Associated declared p < 0.05. Results: The 59.5% (95% CI: 54.5– 64.5). Stage 1 most common (30.95%). odds higher age group 50– 60 years (adjusted ratio (AOR)=2.5, 95% confidence interval (CI) (1.27– 4.90)), urban area (AOR = 2.8, CI (1.08– 7.18)), longer duration =1.16, 1.25)), BMI ≥ 25 kg/m 3.2, (1.71– 5.96)), poor glycemic control 3.0, (1.75– 5.19)), who current cigarette smokers 3.8, (1.98– 14.96)). Conclusion: majority have blood pressure control. Hence, DM care providers other health sector stakeholders work collaboration prevent it through designing appropriate strategies especially for those developing Keywords: hypertension, factors, mellitus,

Язык: Английский

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The association between multimorbidity and health-related quality of life: a cross-sectional survey among community middle-aged and elderly residents in southern China

Health and Quality of Life Outcomes, Год журнала: 2019, Номер 17(1)

Опубликована: Июнь 24, 2019

Multimorbidity is common among the middle-aged and elderly residents. And it associated to reduction of health-related quality life (HRQoL), including physical psychological dimensions. However, there are few studies that have paid attention HRQoL residents with multimorbidity in China. Therefore, this study aims investigate relationships between different patterns adults China.Based on a cross-sectional survey, information regarding 18,137 adults, who were at least 45 years age, was collected through interviews. Self-perceived assessed EQ-5D-3 L instrument, index score calculated using Chinese value set. The Tobit regression used explore impacts groups HRQoL.Of respondents, more than fifth (3773,20.8%) people had multimorbidity. Mean (SD) EQ-5D VAS values 0.95(0.14) 76.02(13.66), respectively. Significant correlations found lower increasing numbers chronic conditions (P < 0.001). Most diseases co-occurred frequently, association hypertension diabetes mellitus strongest (adjusted OR = 3.82). most prevalent disease (5052,27.9%), pair (841,4.6%). Among those high prevalence, effects ranged from pain (adjust b - 0.036 0.008). In patterns, co-occurrence bone 0.039) greatest impact HRQoL.The declines by More should be effect not simply added two diseases, but changes combination. Identifying can provide targeted measures improve HRQoL.

Язык: Английский

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Associations of metabolic disorders with hypertension and cardiovascular disease: recent findings and therapeutic perspectives

Hypertension Research, Год журнала: 2024, Номер 47(12), С. 3338 - 3344

Опубликована: Май 29, 2024

Язык: Английский

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The influence of different forms of apple products on all-cause mortality in patients with hypertension

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 24, 2025

Objective Apple consumption has a positive effect on human health. Some studies have shown that an appropriate amount of apple intake can reduce the incidence hypertension. However, few investigated whether eating different forms apples same benefits as whole apples. This study is aimed to evaluate all-cause mortality in patients with Methods The included 2,368 All participants were followed up for at least 10 years. Cox regression model was constructed analyze correlation between apple, juice, and sauce Results 3–6 times/week associated 48% reduction risk hypertension (HR = 0.52, 95% CI: 0.37–0.72, p &lt; 0.001). juice 1.02, 0.67–1.56, 0.930) 1.28, 0.59–2.74, 0.531) tended increase death hypertension, although this did not obtain statistically result. Conclusion Moderate reduced whereas may death.

Язык: Английский

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Hypertension and type 2 diabetes: lights and shadows about causality

Journal of Human Hypertension, Год журнала: 2019, Номер 34(2), С. 91 - 93

Опубликована: Окт. 21, 2019

Язык: Английский

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Determining the Prevalence of Primary Aldosteronism in Patients With New-Onset Type 2 Diabetes and Hypertension

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2020, Номер 105(4), С. 1079 - 1085

Опубликована: Март 12, 2020

Abstract Context Despite a high prevalence of hypertension in diabetes and close relationship between primary aldosteronism (PA) glucose metabolism, few study concerns the PA with hypertension. Objective This aimed to detect patients new-onset type 2 (T2D) explore association diabetes. Methods A total 256 outpatients T2D were screened for PA. Plasma aldosterone concentration (PAC), plasma renin activity (PRA) measured. Patients an ratio (ARR) ≥ 30 ng/dL/ng/mL/h PAC 15 ng/dL underwent confirmatory captopril challenge test (CCT) The diagnostic criteria were, after CCT, (1) decreased &lt; 30%, (2) ARR maintained ng/dL/ng/mL/h, (3) was 11 ng/dL. Results Of consecutive patients, 99 (39%) positive screening test, 49 (19%) diagnosed Compared those groups (screening −) B +, CCT −), group C (diagnosed PA) had higher percentage systolic blood pressure 160 mmHg, less family history hypertension, lower serum potassium. levels, but PRA than A. Homeostatic model assessment insulin resistance (HOMA-IR) positively associated level among diabetic patients. Conclusion is at least 19%. Higher may be related

Язык: Английский

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Prevalence and associated factors of hypertension among adults with diabetes mellitus in northern Sudan: a cross-sectional study

BMC Cardiovascular Disorders, Год журнала: 2021, Номер 21(1)

Опубликована: Апрель 10, 2021

Abstract Background Hypertension and diabetes mellitus (DM), are highly prevalent worldwide health non-communicable diseases, associated with chronic complications. The co-existence of both conditions accelerates the related complications increases morbidities mortalities. A cross-sectional study was conducted in Nahr an Nil State (River Nile State) Sudan between May August 2018 to identify prevalence hypertension risk factors among patients DM that region. Results median (interquartile) age 1,973 enrolled 58.0 (50.0‒65.0) years, 818 (45.6%) were males. duration 5.0 (3.0‒9.0) years. Of participants, 21.7%, 1.3%, 37.1%, 39.9% normal weight, underweight, overweight, obese, respectively. 854 (47.6%) also had hypertension. Logistic regression analyses showed elderly (adjusted odds ratio [AOR] = 1.03, 95%; confidence interval [CI] 1.02‒1.04), males (AOR 2.96, CI 2.15‒4.07), employed 1.92, 1.38‒2.70), obese 1.59, 1.21‒2.08), diabetic foot (DF) 2.45, 1.72‒3.47) at higher for Conversely, Type 2 (T2DM) 0.63, 0.50‒0.80) lower There no significant association uncontrolled DM, Conclusion This a high DM. Notably, older age, male gender, employment, DF, obesity predictors

Язык: Английский

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Recent understandings about hypertension management in type 2 diabetes: What are the roles of SGLT2 inhibitor, GLP-1 receptor agonist, and finerenone?

Hypertension Research, Год журнала: 2023, Номер 46(8), С. 1892 - 1899

Опубликована: Май 31, 2023

Язык: Английский

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Clinical features and therapeutic perspectives on hypertension in diabetics

Hypertension Research, Год журнала: 2018, Номер 41(4), С. 213 - 229

Опубликована: Фев. 5, 2018

Over 50% of patients with diabetes mellitus, either type 1 or 2, ultimately develop hypertension as a complication. In diabetics, this further increases the incidence cardiovascular disease (CVD) by 2- to 3-fold and accelerates progression diabetic nephropathy. Arteriosclerosis, clinical feature in develops advances from young age. Therefore, providing treatment, it is necessary evaluate degree arteriosclerosis. Diabetic are encouraged strictly control their blood glucose levels. Recently developed drugs, such GLP-1 receptor agonists, DPP-4 inhibitors SGLT2 inhibitors, also have hypotensive actions, making them ideal for use diabetics hypertension. agonists reportedly suppress onset CVD, well The possibility hypoglycemia triggering pressure elevation arrhythmia has been noted, so key point here not cause hypoglycemia. selecting agents, we must choose types that do aggravate insulin resistance engage treatment considers both nocturnal morning addition, facing an aging society, there growing need treatments excessive reduction Favorable lifelong increasingly important accompanied

Язык: Английский

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