Microglia and macrophages in brain homeostasis and disease

Nature reviews. Immunology, Год журнала: 2017, Номер 18(4), С. 225 - 242

Опубликована: Ноя. 20, 2017

Язык: Английский

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Microglia emerge as central players in brain disease

Nature Medicine, Год журнала: 2017, Номер 23(9), С. 1018 - 1027

Опубликована: Сен. 1, 2017

Язык: Английский

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Microglia Biology: One Century of Evolving Concepts

Cell, Год журнала: 2019, Номер 179(2), С. 292 - 311

Опубликована: Окт. 1, 2019

Язык: Английский

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Microglia states and nomenclature: A field at its crossroads

Neuron, Год журнала: 2022, Номер 110(21), С. 3458 - 3483

Опубликована: Ноя. 1, 2022

Язык: Английский

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Negative feedback control of neuronal activity by microglia

Nature, Год журнала: 2020, Номер 586(7829), С. 417 - 423

Опубликована: Сен. 30, 2020

Язык: Английский

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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Nature Communications, Год журнала: 2018, Номер 9(1)

Опубликована: Март 26, 2018

Abstract Microglia are highly motile glial cells that proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads an excess immature connections, thought be the result impaired phagocytosis synapses by microglia. However, until now direct has not been reported fundamental questions remain about precise structures phagocytic mechanisms involved. Here we used light sheet fluorescence microscopy follow microglia–synapse interactions in developing organotypic hippocampal cultures, complemented a 3D ultrastructural characterization using correlative electron (CLEM). Our findings define set dynamic interactions, including selective partial phagocytosis, or trogocytosis ( trogo -: nibble), presynaptic induction postsynaptic spine head filopodia These allow us propose mechanism for facilitatory role remodeling maturation.

Язык: Английский

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Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity

Cell, Год журнала: 2020, Номер 182(2), С. 388 - 403.e15

Опубликована: Июль 1, 2020

Язык: Английский

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The semantics of microglia activation: neuroinflammation, homeostasis, and stress

Journal of Neuroinflammation, Год журнала: 2021, Номер 18(1)

Опубликована: Ноя. 6, 2021

Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area neuroscience. Initial reports focused on classical immune functions microglia pathological contexts, however, immunological concepts from these studies have been applied to describe neuro-immune interactions the absence disease, injury, or infection. Indeed, terms such 'microglia activation' 'neuroinflammation' used ubiquitously changes disparate contexts; particularly stress research, where prompt undue comparisons conditions. This creates a barrier for investigators new neuro-immunology ultimately hinders our understanding effects microglia. As more seek understand role neurobiology behavior, it is increasingly important develop standard methods study define microglial phenotype function. In this review, we summarize primary research physiological contexts. Further, propose framework better microglia1 chronic stress. approach will enable precise characterization different which should facilitate development microglia-directed therapeutics psychiatric neurological disease.

Язык: Английский

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Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1

Neuron, Год журнала: 2017, Номер 97(2), С. 299 - 312.e6

Опубликована: Дек. 28, 2017

Microglia exhibit two modes of motility: they constantly extend and retract their processes to survey the brain, but also send out targeted envelop sites tissue damage. We now show that these motility differ mechanistically. identify two-pore domain channel THIK-1 as main K+ expressed in microglia situ. is tonically active, its activity potentiated by P2Y12 receptors. Inhibiting function pharmacologically or gene knockout depolarizes microglia, which decreases microglial ramification thus reduces surveillance, whereas blocking receptors does not affect membrane potential, ramification, surveillance. In contrast, process outgrowth damaged requires receptor activation unaffected THIK-1. Block inhibits release pro-inflammatory cytokine interleukin-1β from activated consistent with loss being needed for inflammasome assembly. Thus, immune surveillance require activity.

Язык: Английский

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Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

Neuron, Год журнала: 2017, Номер 95(2), С. 341 - 356.e6

Опубликована: Июль 1, 2017

Язык: Английский

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