Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS DOI
Travis E. Faust, Georgia Gunner, Dorothy P. Schafer

et al.

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(11), P. 657 - 673

Published: Sept. 20, 2021

Language: Английский

Microglia and macrophages in brain homeostasis and disease DOI
Qingyun Li, Ben A. Barres

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 18(4), P. 225 - 242

Published: Nov. 20, 2017

Language: Английский

Citations

1628
Microglia emerge as central players in brain disease DOI
Michael W. Salter, Beth Stevens

Nature Medicine, Journal Year: 2017, Volume and Issue: 23(9), P. 1018 - 1027

Published: Sept. 1, 2017

Language: Английский

Citations

1465
Microglia Biology: One Century of Evolving Concepts DOI Creative Commons
Marco Prinz, Steffen Jung, Josef Priller

et al.

Cell, Journal Year: 2019, Volume and Issue: 179(2), P. 292 - 311

Published: Oct. 1, 2019

Language: Английский

Citations

1065
Microglia states and nomenclature: A field at its crossroads DOI Creative Commons
Rosa Chiara Paolicelli, Amanda Sierra, Beth Stevens

et al.

Neuron, Journal Year: 2022, Volume and Issue: 110(21), P. 3458 - 3483

Published: Nov. 1, 2022

Language: Английский

Citations

1065
Negative feedback control of neuronal activity by microglia DOI
Ana Badimon, Hayley J. Strasburger, Pinar Ayata

et al.

Nature, Journal Year: 2020, Volume and Issue: 586(7829), P. 417 - 423

Published: Sept. 30, 2020

Language: Английский

Citations

738
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction DOI Creative Commons
Laetitia Weinhard, Giulia Di Bartolomei, Giulia Bolasco

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: March 26, 2018

Abstract Microglia are highly motile glial cells that proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads an excess immature connections, thought be the result impaired phagocytosis synapses by microglia. However, until now direct has not been reported fundamental questions remain about precise structures phagocytic mechanisms involved. Here we used light sheet fluorescence microscopy follow microglia–synapse interactions in developing organotypic hippocampal cultures, complemented a 3D ultrastructural characterization using correlative electron (CLEM). Our findings define set dynamic interactions, including selective partial phagocytosis, or trogocytosis ( trogo -: nibble), presynaptic induction postsynaptic spine head filopodia These allow us propose mechanism for facilitatory role remodeling maturation.

Language: Английский

Citations

691
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity DOI Creative Commons
Phi T. Nguyen, Leah C. Dorman, Simon Pan

et al.

Cell, Journal Year: 2020, Volume and Issue: 182(2), P. 388 - 403.e15

Published: July 1, 2020

Language: Английский

Citations

482
The semantics of microglia activation: neuroinflammation, homeostasis, and stress DOI Creative Commons
Samuel C. Woodburn, Justin L. Bollinger, Eric S. Wohleb

et al.

Journal of Neuroinflammation, Journal Year: 2021, Volume and Issue: 18(1)

Published: Nov. 6, 2021

Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area neuroscience. Initial reports focused on classical immune functions microglia pathological contexts, however, immunological concepts from these studies have been applied to describe neuro-immune interactions the absence disease, injury, or infection. Indeed, terms such 'microglia activation' 'neuroinflammation' used ubiquitously changes disparate contexts; particularly stress research, where prompt undue comparisons conditions. This creates a barrier for investigators new neuro-immunology ultimately hinders our understanding effects microglia. As more seek understand role neurobiology behavior, it is increasingly important develop standard methods study define microglial phenotype function. In this review, we summarize primary research physiological contexts. Further, propose framework better microglia1 chronic stress. approach will enable precise characterization different which should facilitate development microglia-directed therapeutics psychiatric neurological disease.

Language: Английский

Citations

446
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1 DOI Creative Commons
Christian Madry, Vasiliki Kyrargyri, I. Lorena Arancibia-Cárcamo

et al.

Neuron, Journal Year: 2017, Volume and Issue: 97(2), P. 299 - 312.e6

Published: Dec. 28, 2017

Microglia exhibit two modes of motility: they constantly extend and retract their processes to survey the brain, but also send out targeted envelop sites tissue damage. We now show that these motility differ mechanistically. identify two-pore domain channel THIK-1 as main K+ expressed in microglia situ. is tonically active, its activity potentiated by P2Y12 receptors. Inhibiting function pharmacologically or gene knockout depolarizes microglia, which decreases microglial ramification thus reduces surveillance, whereas blocking receptors does not affect membrane potential, ramification, surveillance. In contrast, process outgrowth damaged requires receptor activation unaffected THIK-1. Block inhibits release pro-inflammatory cytokine interleukin-1β from activated consistent with loss being needed for inflammasome assembly. Thus, immune surveillance require activity.

Language: Английский

Citations

394
Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia DOI Creative Commons
Lindsay M. De Biase,

Kornel E. Schuebel,

Zachary Fusfeld

et al.

Neuron, Journal Year: 2017, Volume and Issue: 95(2), P. 341 - 356.e6

Published: July 1, 2017

Language: Английский

Citations

374