Journal of Leukocyte Biology,
Год журнала:
2017,
Номер
103(2), С. 233 - 257
Опубликована: Авг. 31, 2017
The
inflammasome
is
a
macromolecular
protein
complex
that
mediates
proteolytic
cleavage
of
pro-IL-1β
and
-IL-18
induces
cell
death
in
the
form
pyroptosis.
Certain
nucleotide-binding
oligomerization
domain-like
receptors
(NLRs),
absent
melanoma
2
(AIM2)-like
(ALRs),
or
tripartite
motif
(TRIM)
family
trigger
assembly
an
response
to
pathogen-associated
molecular
patterns
(PAMPs)
danger-associated
(DAMPs).
Recent
studies
have
revealed
multitude
host
components
signals
are
essential
for
controlling
canonical
noncanonical
activation
These
include
pore-forming
gasdermin
proteins,
never
mitosis
A-related
kinase
7
(NEK7),
IFN-inducible
proteins
(IFIs),
reactive
oxygen
species
(ROS),
autophagy,
potassium
efflux,
mitochondrial
perturbations,
microbial
metabolites.
Here,
we
provide
comprehensive
overview
signaling
mechanisms
stringent
regulation
over
effector
functions
inflammasome.
Signal Transduction and Targeted Therapy,
Год журнала:
2021,
Номер
6(1)
Опубликована: Март 29, 2021
Abstract
Currently,
pyroptosis
has
received
more
and
attention
because
of
its
association
with
innate
immunity
disease.
The
research
scope
expanded
the
discovery
gasdermin
family.
A
great
deal
evidence
shows
that
can
affect
development
tumors.
relationship
between
tumors
is
diverse
in
different
tissues
genetic
backgrounds.
In
this
review,
we
provide
basic
knowledge
pyroptosis,
explain
tumors,
focus
on
significance
tumor
treatment.
addition,
further
summarize
possibility
as
a
potential
treatment
strategy
describe
side
effects
radiotherapy
chemotherapy
caused
by
pyroptosis.
brief,
double-edged
sword
for
rational
use
dual
effect
will
help
us
explore
formation
ideas
patients
to
develop
new
drugs
based
Cancers,
Год журнала:
2019,
Номер
11(1), С. 38 - 38
Опубликована: Янв. 3, 2019
Cancer
is
a
multifactorial
pathology
and
it
represents
the
second
leading
cause
of
death
worldwide.
In
recent
years,
numerous
studies
highlighted
dual
role
gut
microbiota
in
preserving
host’s
health.
Gut
resident
bacteria
are
able
to
produce
number
metabolites
bioproducts
necessary
protect
gut’s
homeostasis.
Conversely,
several
subpopulations
may
expand
during
pathological
dysbiosis
therefore
high
levels
toxins
capable,
turn,
trigger
both
inflammation
tumorigenesis.
Importantly,
can
interact
with
host
either
modulating
directly
epithelium
or
immune
system.
Numerous
populating
bacteria,
called
probiotics,
have
been
identified
as
protective
against
genesis
tumors.
Given
their
capability
homeostasis,
probiotics
currently
tested
help
fight
cancer
patients
subjected
chemotherapy
radiotherapy.
Most
recently,
three
independent
show
that
specific
species
potentiate
positive
outcome
anti-cancer
immunotherapy.
The
highly
significant
studies,
uncovering
tight
association
between
tumorigenesis,
well
therapy,
here
described.
Lactobacillus
rhamnosus
GG
(LGG),
most
studied
probiotic
model
cancer,
also
reported.
Overall,
according
findings
summarized,
novel
strategies
integrating
such
LGG,
conventional
therapies
strongly
encouraged.
Inflammation and Regeneration,
Год журнала:
2019,
Номер
39(1)
Опубликована: Июнь 5, 2019
Interleukin-1,
an
inflammatory
cytokine,
is
considered
to
have
diverse
physiological
functions
and
pathological
significances
play
important
role
in
health
disease.
In
this
decade,
interleukin-1
family
members
been
expanding
evidence
accumulating
that
highlights
the
importance
of
linking
innate
immunity
with
a
broad
spectrum
diseases
beyond
diseases.
review,
we
look
back
on
definition
"inflammation"
traditional
general
pathology
discuss
new
insights
into
view
its
history
molecular
bases
diseases,
as
well
current
progress
therapeutics.
The Journal of Experimental Medicine,
Год журнала:
2017,
Номер
214(5), С. 1351 - 1370
Опубликована: Апрель 12, 2017
Inflammation
in
the
brain
accompanies
several
high-impact
neurological
diseases
including
multiple
sclerosis
(MS),
stroke,
and
Alzheimer's
disease.
Neuroinflammation
is
sterile,
as
damage-associated
molecular
patterns
rather
than
microbial
pathogens
elicit
response.
The
inflammasome,
which
leads
to
caspase-1
activation,
implicated
neuroinflammation.
In
this
study,
we
reveal
that
lysophosphatidylcholine
(LPC),
a
molecule
associated
with
neurodegeneration
demyelination,
elicits
NLRP3
NLRC4
inflammasome
activation
microglia
astrocytes,
are
central
players
LPC-activated
also
requires
ASC
(apoptotic
speck
containing
protein
CARD),
caspase-1,
cathepsin-mediated
degradation,
calcium
mobilization,
potassium
efflux
but
not
caspase-11.
To
study
physiological
relevance,
Nlrc4-/-
Nlrp3-/-
mice
studied
cuprizone
model
of
neuroinflammation
demyelination.
Mice
lacking
both
genes
show
most
pronounced
reduction
astrogliosis
microglial
accumulation
accompanied
by
decreased
expression
LPC
receptor
G2A,
whereas
MS
patient
samples
increased
G2A.
These
results
NLRP3,
normally
form
distinct
inflammasomes,
activate
an
LPC-induced
important
microgliosis.
Cancers,
Год журнала:
2020,
Номер
12(7), С. 1791 - 1791
Опубликована: Июль 4, 2020
Within
a
tumor,
IL-1β
is
produced
and
secreted
by
various
cell
types,
such
as
immune
cells,
fibroblasts,
or
cancer
cells.
The
IL1B
gene
induced
after
“priming”
of
the
cells
second
signal
required
to
allow
maturation
inflammasome-activated
caspase-1.
then
released
leads
transcription
target
genes
through
its
ligation
with
IL-1R1
on
expression
are
guided
polymorphisms
cellular
context.
In
cancer,
has
pleiotropic
effects
angiogenesis,
proliferation,
migration,
metastasis.
Moreover,
anti-cancer
treatments
able
promote
production
opposite
progression.
This
raises
question
whether
not
use
inhibitors
in
treatment.
