Transforming Growth Factor-β Signaling in Immunity and Cancer

Immunity, Год журнала: 2019, Номер 50(4), С. 924 - 940

Опубликована: Апрель 1, 2019

Язык: Английский

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Innate Lymphoid Cells: 10 Years On

Cell, Год журнала: 2018, Номер 174(5), С. 1054 - 1066

Опубликована: Авг. 1, 2018

Язык: Английский

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Tumor angiogenesis: causes, consequences, challenges and opportunities

Cellular and Molecular Life Sciences, Год журнала: 2019, Номер 77(9), С. 1745 - 1770

Опубликована: Ноя. 6, 2019

Abstract Tumor vascularization occurs through several distinct biological processes, which not only vary between tumor type and anatomic location, but also occur simultaneously within the same cancer tissue. These processes are orchestrated by a range of secreted factors signaling pathways can involve participation non-endothelial cells, such as progenitors or stem cells. Anti-angiogenic therapies using either antibodies tyrosine kinase inhibitors have been approved to treat types cancer. However, benefit treatment has so far modest, some patients responding at all others acquiring resistance. It is becoming increasingly clear that blocking tumors from accessing circulation an easy task accomplish. vessel functionality gene expression often differ vastly when comparing different subtypes, phenotype be markedly heterogeneous single tumor. Here, we summarize current understanding cellular molecular mechanisms involved in angiogenesis discuss challenges opportunities associated with vascular targeting.

Язык: Английский

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Cancer immunoediting and resistance to T cell-based immunotherapy

Nature Reviews Clinical Oncology, Год журнала: 2018, Номер 16(3), С. 151 - 167

Опубликована: Дек. 6, 2018

Язык: Английский

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NK cells for cancer immunotherapy

Nature Reviews Drug Discovery, Год журнала: 2020, Номер 19(3), С. 200 - 218

Опубликована: Янв. 6, 2020

Язык: Английский

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Natural killer cells and other innate lymphoid cells in cancer

Nature reviews. Immunology, Год журнала: 2018, Номер 18(11), С. 671 - 688

Опубликована: Сен. 12, 2018

Язык: Английский

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Harnessing innate immunity in cancer therapy

Nature, Год журнала: 2019, Номер 574(7776), С. 45 - 56

Опубликована: Окт. 2, 2019

Язык: Английский

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Tumor-infiltrating lymphocytes in the immunotherapy era

Cellular and Molecular Immunology, Год журнала: 2020, Номер 18(4), С. 842 - 859

Опубликована: Ноя. 2, 2020

Язык: Английский

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The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Frontiers in Immunology, Год журнала: 2020, Номер 11

Опубликована: Май 15, 2020

The success of cancer immunotherapy relies on the knowledge tumor microenvironment and immune evasion mechanisms in which tumor, stroma infiltrating cells function a complex network. potential barriers that profoundly challenge overall clinical outcome promising therapies need to be fully identified counteracted. Although has increasingly been applied, we are far from understanding how utilize different strategies best way combine therapeutic options optimize benefit. This review intends give contemporary detailed overview roles cells, exosomes molecules acting they relate activation escape. Further, current novel immunotherapeutic will discussed.

Язык: Английский

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NK cell-based cancer immunotherapy: from basic biology to clinical development

Journal of Hematology & Oncology, Год журнала: 2021, Номер 14(1)

Опубликована: Янв. 6, 2021

Abstract Natural killer (NK) cell is a specialized immune effector type that plays critical role in activation against abnormal cells. Different from events required for T activation, NK governed by the interaction of receptors with target cells, independent antigen processing and presentation. Due to relatively unsophisticated cues has gained significant attention field cancer immunotherapy. Many efforts are emerging developing engineering cell-based In this review, we provide our current understandings biology, ongoing pre-clinical clinical development therapies discuss progress, challenges, future perspectives.

Язык: Английский

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