Gene therapy comes of age

Science, Год журнала: 2018, Номер 359(6372)

Опубликована: Янв. 12, 2018

Gene therapy: The power of persistence Nearly 50 years after the concept was first proposed, gene therapy is now considered a promising treatment option for several human diseases. path to success has been long and tortuous. Serious adverse effects were encountered in early clinical studies, but this fueled basic research that led safer more efficient transfer vectors. various forms produced benefits patients with blindness, neuromuscular disease, hemophilia, immunodeficiencies, cancer. Dunbar et al. review pioneering work field its current state, describe gene-editing technologies are expected play major role field's future, discuss practical challenges getting these therapies who need them. Science , issue p. eaan4672

Язык: Английский

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The Principles of Engineering Immune Cells to Treat Cancer

Cell, Год журнала: 2017, Номер 168(4), С. 724 - 740

Опубликована: Фев. 1, 2017

Язык: Английский

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Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

Cell Metabolism, Год журнала: 2017, Номер 26(1), С. 94 - 109

Опубликована: Июль 1, 2017

Язык: Английский

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Targeting of cancer neoantigens with donor-derived T cell receptor repertoires

Science, Год журнала: 2016, Номер 352(6291), С. 1337 - 1341

Опубликована: Май 20, 2016

Outsourcing cancer immunotherapy Successful depends on a patient's T cells recognizing tumor-specific mutations and then waging lethal attack. Despite tumors harboring many mutations, most individuals have very few that respond to these so-called “neo-antigens.” Strønen et al. isolated from healthy donors responded predicted neo-antigens expressed by melanomas taken three patients, sometimes including the own ignored (see Perspective Yadav Delamarre). Testing whether such an outsourcing strategy could improve clinical outcomes will be important next step. Science , this issue p. 1337 ; see also 1275

Язык: Английский

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Acquired resistance to immunotherapy and future challenges

Nature reviews. Cancer, Год журнала: 2016, Номер 16(2), С. 121 - 126

Опубликована: Янв. 29, 2016

Язык: Английский

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Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy

Chemical Society Reviews, Год журнала: 2016, Номер 45(22), С. 6250 - 6269

Опубликована: Янв. 1, 2016

Metastasis is directly or indirectly responsible for the majority of cancer deaths. Anti-metastasis treatment thus key to cure cancer. Recent development in nanomedicine has shown great promise tackling metastasis. In recent years, nanoparticle-based drug delivery systems have been extensively explored improving treatment, showing ability reduce risk tumor metastasis compared with conventional chemotherapy. Photothermal therapy, by employing nano-theranostic agents, also found be able inhibit lymphatic Moreover, post-immunological effects certain types nano-therapies may utilized treat metastasis, presenting an exciting new avenue towards successful treatment. this review article, we would like summarize latest research advances various emerging approaches and discuss future prospects field as well clinical translation potential these techniques.

Язык: Английский

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New development in CAR-T cell therapy

Journal of Hematology & Oncology, Год журнала: 2017, Номер 10(1)

Опубликована: Фев. 21, 2017

Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably anti-CD19 CAR-T for acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate. However, tumor escape has emerged as main challenge the long-term disease control of this promising immunotherapy malignancies. In addition, success encountered significant hurdles translation solid tumors, and safety on-target/off-tumor recognition normal tissues is one reasons. mini-review, we characterize some mechanisms loss relapse new strategies address issue. discuss novel CAR designs that are being considered enhance therapy tumors.

Язык: Английский

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The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity

Cancer Immunology Immunotherapy, Год журнала: 2017, Номер 66(11), С. 1425 - 1436

Опубликована: Июнь 28, 2017

Язык: Английский

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Current status and future directions of cancer immunotherapy

Journal of Cancer, Год журнала: 2018, Номер 9(10), С. 1773 - 1781

Опубликована: Янв. 1, 2018

In the past decades, our knowledge about relationship between cancer and immune system has increased considerably.Recent years' success of immunotherapy including monoclonal antibodies (mAbs), vaccines, adoptive therapy checkpoint revolutionized traditional treatment.However, challenges still exist in this field.Personalized combination therapies via new techniques will be next promising strategies for future treatment direction.

Язык: Английский

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Target Expression, Generation, Preclinical Activity, and Pharmacokinetics of the BCMA-T Cell Bispecific Antibody EM801 for Multiple Myeloma Treatment

Cancer Cell, Год журнала: 2017, Номер 31(3), С. 396 - 410

Опубликована: Март 1, 2017

Язык: Английский

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