Genes & Development,
Год журнала:
2020,
Номер
34(23-24), С. 1565 - 1576
Опубликована: Дек. 1, 2020
Cellular
senescence
is
a
stress
response
that
elicits
permanent
cell
cycle
arrest
and
triggers
profound
phenotypic
changes
such
as
the
production
of
bioactive
secretome,
referred
to
senescence-associated
secretory
phenotype
(SASP).
Acute
induction
protects
against
cancer
limits
fibrosis,
but
lingering
senescent
cells
drive
age-related
disorders.
Thus,
targeting
delay
aging
limit
dysfunction,
known
“senotherapy,”
gaining
momentum.
While
drugs
selectively
kill
cells,
termed
“senolytics”
are
major
focus,
SASP-centered
approaches
emerging
alternatives
target
diseases.
Here,
we
summarize
regulation
functions
SASP
highlight
therapeutic
potential
modulation
complimentary
or
an
alternative
current
senolytic
approaches.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Дек. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(20), С. 7794 - 7794
Опубликована: Окт. 21, 2020
Emerging
autologous
cellular
therapies
that
utilize
platelet-rich
plasma
(PRP)
applications
have
the
potential
to
play
adjunctive
roles
in
a
variety
of
regenerative
medicine
treatment
plans.
There
is
global
unmet
need
for
tissue
repair
strategies
treat
musculoskeletal
(MSK)
and
spinal
disorders,
osteoarthritis
(OA),
patients
with
chronic
complex
recalcitrant
wounds.
PRP
therapy
based
on
fact
platelet
growth
factors
(PGFs)
support
three
phases
wound
healing
cascade
(inflammation,
proliferation,
remodeling).
Many
different
formulations
been
evaluated,
originating
from
human,
vitro,
animal
studies.
However,
recommendations
vitro
research
often
lead
clinical
outcomes
because
it
difficult
translate
non-clinical
study
methodology
human
protocols.
In
recent
years,
progress
has
made
understanding
technology
concepts
bioformulation,
new
directives
indications
suggested.
this
review,
we
will
discuss
developments
regarding
preparation
composition
dosing,
leukocyte
activities
concerning
innate
adaptive
immunomodulation,
serotonin
(5-HT)
effects,
pain
killing.
Furthermore,
mechanisms
related
inflammation
angiogenesis
processes.
Lastly,
review
effect
certain
drugs
activity,
combination
rehabilitation
Circulation Research,
Год журнала:
2018,
Номер
123(7), С. 849 - 867
Опубликована: Сен. 13, 2018
Aging
of
the
vasculature
plays
a
central
role
in
morbidity
and
mortality
older
people.
To
develop
novel
treatments
for
amelioration
unsuccessful
vascular
aging
prevention
age-related
pathologies,
it
is
essential
to
understand
cellular
functional
changes
that
occur
during
aging.
In
this
review,
pathophysiological
roles
fundamental
molecular
mechanisms
aging,
including
oxidative
stress,
mitochondrial
dysfunction,
impaired
resistance
stressors,
chronic
low-grade
inflammation,
genomic
instability,
senescence,
epigenetic
alterations,
loss
protein
homeostasis,
deregulated
nutrient
sensing,
stem
cell
dysfunction
system
are
considered
terms
their
contribution
pathogenesis
both
microvascular
macrovascular
diseases
associated
with
old
age.
The
importance
progeronic
antigeronic
circulating
factors
relation
development
phenotypes
discussed.
Finally,
future
directions
opportunities
interventions
prevent/delay
pathologies
by
targeting
processes
presented.
Nature Communications,
Год журнала:
2017,
Номер
8(1)
Опубликована: Авг. 29, 2017
Aging
is
the
main
risk
factor
for
many
chronic
degenerative
diseases
and
cancer.
Increased
senescent
cell
burden
in
various
tissues
a
major
contributor
to
aging
age-related
diseases.
Recently,
new
class
of
drugs
termed
senolytics
were
demonstrated
extending
healthspan,
reducing
frailty
improving
stem
function
multiple
murine
models
aging.
To
identify
novel
more
optimal
senotherapeutic
combinations,
we
established
senescence
associated
β-galactosidase
assay
as
screening
platform
rapidly
that
specifically
affect
cells.
We
used
primary
Ercc1
