Biomedicine & Pharmacotherapy,
Год журнала:
2019,
Номер
117, С. 109138 - 109138
Опубликована: Июнь 24, 2019
Type
2
diabetes
mellitus
(T2DM)
is
a
common
clinical
chronic
disease,
while
its
pathogenesis
still
inconclusive.
Intestinal
flora,
the
largest
micro-ecological
system
in
human
body,
involved
in,
meanwhile
has
major
impact
on
body's
material
and
energy
metabolism.
Recent
studies
have
shown
that
addition
to
obesity,
genetics,
islet
dysfunction,
disturbance
of
intestinal
flora
may
partly
give
rise
diabetes.
In
this
paper,
we
summarized
current
research
correlation
between
T2DM
concluded
pathological
mechanisms
T2DM.
Moreover,
ideas
methods
prevention
treatment
based
were
proposed,
providing
theoretical
basis
literature
reference
for
complications
regulation
flora.
Nucleic Acids Research,
Год журнала:
2021,
Номер
50(D1), С. D912 - D917
Опубликована: Окт. 21, 2021
The
virulence
factor
database
(VFDB,
http://www.mgc.ac.cn/VFs/)
is
dedicated
to
presenting
a
comprehensive
knowledge
base
and
versatile
analysis
platform
for
bacterial
factors
(VFs).
Recent
developments
in
sequencing
technologies
have
led
increasing
demands
analyze
potential
VFs
within
microbiome
data
that
always
consist
of
many
different
bacteria.
Nevertheless,
the
current
classification
from
various
pathogens
based
on
schemes,
which
create
chaotic
situation
form
barrier
easy
application
VFDB
dataset
future
panbacterial
metagenomic
analyses.
Therefore,
extensive
literature
mining,
we
recently
proposed
general
category
reorganized
accordingly.
Thus,
all
known
32
genera
common
collected
are
well
grouped
into
14
basal
categories
along
with
over
100
subcategories
hierarchical
architecture.
new
coherent
well-defined
will
be
feasible
applicable
terms
factors.
In
addition,
introduced
redesigned
JavaScript-independent
web
interface
website
make
readily
accessible
users
client
settings
worldwide.
