Depression

The Lancet, Год журнала: 2018, Номер 392(10161), С. 2299 - 2312

Опубликована: Ноя. 1, 2018

Язык: Английский

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The role of short-chain fatty acids in microbiota–gut–brain communication

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2019, Номер 16(8), С. 461 - 478

Опубликована: Май 23, 2019

Язык: Английский

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Resting-state connectivity biomarkers define neurophysiological subtypes of depression

Nature Medicine, Год журнала: 2016, Номер 23(1), С. 28 - 38

Опубликована: Дек. 5, 2016

Язык: Английский

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Major depressive disorder

Nature Reviews Disease Primers, Год журнала: 2016, Номер 2(1)

Опубликована: Сен. 15, 2016

Язык: Английский

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Conserved cell types with divergent features in human versus mouse cortex

Nature, Год журнала: 2019, Номер 573(7772), С. 61 - 68

Опубликована: Авг. 21, 2019

Язык: Английский

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A standardized protocol for repeated social defeat stress in mice

Nature Protocols, Год журнала: 2011, Номер 6(8), С. 1183 - 1191

Опубликована: Июль 21, 2011

Язык: Английский

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Human Disease Models inDrosophila melanogasterand the Role of the Fly in Therapeutic Drug Discovery

Pharmacological Reviews, Год журнала: 2011, Номер 63(2), С. 411 - 436

Опубликована: Март 17, 2011

The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic model organism for understanding molecular mechanisms of human diseases. Many basic biological, physiological, neurological properties are conserved between mammals D. nearly 75% disease-causing genes believed to have functional homolog in the fly. In discovery process therapeutics, traditional approaches employ high-throughput screening small molecules that based primarily on vitro cell culture, enzymatic assays, or receptor binding assays. majority positive hits identified through these types screens, unfortunately, found be ineffective and/or toxic subsequent validation experiments whole-animal models. New tools platforms needed arena overcome limitations. incorporation melanogaster into therapeutic holds tremendous promise an enhanced rate higher quality leads. models diseases provide several unique features such as powerful genetics, disease pathways, very low comparative costs. fly can effectively used low- drug screens target discovery. Here, we review biology discuss opportunities central nervous system disorders, inflammatory cardiovascular disease, cancer, diabetes. We also information resources those interested pursuing using process.

Язык: Английский

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Zebrafish as an emerging model for studying complex brain disorders

Trends in Pharmacological Sciences, Год журнала: 2014, Номер 35(2), С. 63 - 75

Опубликована: Янв. 9, 2014

Язык: Английский

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Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits

Cell, Год журнала: 2011, Номер 147(1), С. 235 - 246

Опубликована: Сен. 1, 2011

Язык: Английский

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Scaling Brain Size, Keeping Timing: Evolutionary Preservation of Brain Rhythms

Neuron, Год журнала: 2013, Номер 80(3), С. 751 - 764

Опубликована: Окт. 1, 2013

Язык: Английский

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