Science,
Год журнала:
2021,
Номер
374(6570), С. 1010 - 1015
Опубликована: Ноя. 18, 2021
How
does
the
brain
maintain
fear
within
an
adaptive
range?
We
found
that
insular
cortex
acts
as
a
state-dependent
regulator
of
is
necessary
to
establish
equilibrium
between
extinction
and
maintenance
memories
in
mice.
Whereas
responsiveness
fear-evoking
cues
increased
with
their
certainty
predict
harm,
this
activity
was
attenuated
through
negative
bodily
feedback
arose
from
heart
rate
decelerations
during
freezing.
Perturbation
body-brain
communication
by
vagus
nerve
stimulation
disrupted
balance
similar
inhibition.
Our
data
reveal
integrates
predictive
sensory
interoceptive
signals
provide
graded
bidirectional
teaching
gate
illustrate
how
are
used
functional
equilibrium.
Biological Psychiatry,
Год журнала:
2021,
Номер
89(9), С. 847 - 856
Опубликована: Янв. 8, 2021
Brain
systems
that
promote
maintenance
of
homeostasis
in
the
face
stress
have
significant
adaptive
value.
A
growing
body
work
across
species
demonstrates
a
critical
role
for
amygdala
promoting
by
regulating
physiological
and
behavioral
responses
to
stress.
This
review
focuses
on
an
emerging
evidence
has
begun
delineate
contribution
specific
long-range
circuits
mediating
effects
After
summarizing
major
anatomical
features
its
connectivity
other
limbic
structures,
we
discuss
recent
findings
from
rodents
showing
how
causes
structural
functional
remodeling
neuronal
outputs
defined
cortical
subcortical
target
regions.
We
also
consider
some
environmental
genetic
factors
been
found
moderate
responds
relate
preclinical
literature
current
understanding
pathophysiology
treatment
stress-related
neuropsychiatric
disorders.
Future
effort
translate
these
clinics
may
help
develop
valuable
tools
prevention,
diagnosis,
diseases.
Science,
Год журнала:
2021,
Номер
374(6570), С. 1010 - 1015
Опубликована: Ноя. 18, 2021
How
does
the
brain
maintain
fear
within
an
adaptive
range?
We
found
that
insular
cortex
acts
as
a
state-dependent
regulator
of
is
necessary
to
establish
equilibrium
between
extinction
and
maintenance
memories
in
mice.
Whereas
responsiveness
fear-evoking
cues
increased
with
their
certainty
predict
harm,
this
activity
was
attenuated
through
negative
bodily
feedback
arose
from
heart
rate
decelerations
during
freezing.
Perturbation
body-brain
communication
by
vagus
nerve
stimulation
disrupted
balance
similar
inhibition.
Our
data
reveal
integrates
predictive
sensory
interoceptive
signals
provide
graded
bidirectional
teaching
gate
illustrate
how
are
used
functional
equilibrium.
