Fear balance is maintained by bodily feedback to the insular cortex in mice DOI
Alexandra S. Klein, Nate Dolensek, Caroline Weiand

et al.

Science, Journal Year: 2021, Volume and Issue: 374(6570), P. 1010 - 1015

Published: Nov. 18, 2021

How does the brain maintain fear within an adaptive range? We found that insular cortex acts as a state-dependent regulator of is necessary to establish equilibrium between extinction and maintenance memories in mice. Whereas responsiveness fear-evoking cues increased with their certainty predict harm, this activity was attenuated through negative bodily feedback arose from heart rate decelerations during freezing. Perturbation body-brain communication by vagus nerve stimulation disrupted balance similar inhibition. Our data reveal integrates predictive sensory interoceptive signals provide graded bidirectional teaching gate illustrate how are used functional equilibrium.

Language: Английский

An Emerging Circuit Pharmacology of GABAA Receptors DOI Creative Commons
Elif Engin,

Rebecca S. Benham,

Uwe Rudolph

et al.

Trends in Pharmacological Sciences, Journal Year: 2018, Volume and Issue: 39(8), P. 710 - 732

Published: June 11, 2018

Language: Английский

Citations

184
Mapping gene transcription and neurocognition across human neocortex DOI
Justine Y. Hansen, Ross D. Markello, Jacob W. Vogel

et al.

Nature Human Behaviour, Journal Year: 2021, Volume and Issue: 5(9), P. 1240 - 1250

Published: March 25, 2021

Language: Английский

Citations

166
Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning DOI Creative Commons
Elizabeth K. Unger, Jacob P. Keller, Michael Altermatt

et al.

Cell, Journal Year: 2020, Volume and Issue: 183(7), P. 1986 - 2002.e26

Published: Dec. 1, 2020

Language: Английский

Citations

150
Amygdala Circuit Substrates for Stress Adaptation and Adversity DOI Creative Commons
Wen-Hua Zhang, Junyu Zhang, Andrew Holmes

et al.

Biological Psychiatry, Journal Year: 2021, Volume and Issue: 89(9), P. 847 - 856

Published: Jan. 8, 2021

Brain systems that promote maintenance of homeostasis in the face stress have significant adaptive value. A growing body work across species demonstrates a critical role for amygdala promoting by regulating physiological and behavioral responses to stress. This review focuses on an emerging evidence has begun delineate contribution specific long-range circuits mediating effects After summarizing major anatomical features its connectivity other limbic structures, we discuss recent findings from rodents showing how causes structural functional remodeling neuronal outputs defined cortical subcortical target regions. We also consider some environmental genetic factors been found moderate responds relate preclinical literature current understanding pathophysiology treatment stress-related neuropsychiatric disorders. Future effort translate these clinics may help develop valuable tools prevention, diagnosis, diseases.

Language: Английский

Citations

140
Fear balance is maintained by bodily feedback to the insular cortex in mice DOI
Alexandra S. Klein, Nate Dolensek, Caroline Weiand

et al.

Science, Journal Year: 2021, Volume and Issue: 374(6570), P. 1010 - 1015

Published: Nov. 18, 2021

How does the brain maintain fear within an adaptive range? We found that insular cortex acts as a state-dependent regulator of is necessary to establish equilibrium between extinction and maintenance memories in mice. Whereas responsiveness fear-evoking cues increased with their certainty predict harm, this activity was attenuated through negative bodily feedback arose from heart rate decelerations during freezing. Perturbation body-brain communication by vagus nerve stimulation disrupted balance similar inhibition. Our data reveal integrates predictive sensory interoceptive signals provide graded bidirectional teaching gate illustrate how are used functional equilibrium.

Language: Английский

Citations

128