Dissociable encoding of motivated behavior by parallel thalamo-striatal projections

Current Biology, Год журнала: 2024, Номер 34(7), С. 1549 - 1560.e3

Опубликована: Март 7, 2024

The successful pursuit of goals requires the coordinated execution and termination actions that lead to positive outcomes. This process relies on motivational states are guided by internal drivers, such as hunger or fear. However, mechanisms which brain tracks shape instrumental not fully understood. paraventricular nucleus thalamus (PVT) is a midline thalamic shapes motivated behaviors via its projections accumbens (NAc)

Язык: Английский

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Conjoint specification of action by neocortex and striatum

Neuron, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Automatic Generation of Precast Concrete Component Fabrication Drawings Based on BIM and Multi-Agent Reinforcement Learning

Buildings, Год журнала: 2025, Номер 15(2), С. 284 - 284

Опубликована: Янв. 19, 2025

Fabrication drawings are essential for design evaluation, lean manufacturing, and quality detection of precast concrete (PC) components. Due to the complicated shape PC components, fabrication drawing needs be customized determine manufacturing dimensions relevant assembly connections. However, traditional manual method is time-consuming, labor-intensive, error-prone. This paper presents a BIM-based framework automatically generate readable components using building information modeling (BIM) multi-agent reinforcement learning (MARL). Firstly, an automated generation developed transform BIM model view block. Secondly, graph-based representation used create relationship between blocks, reward mechanism established according readability criterion. Subsequently, block layout modeled as optimization problem, internal spacing position functional category blocks regarded agents. Finally, agents collaborate interact with environment find optimal guidance mechanism. Two different algorithms utilized validate efficiency proposed (MADQN). The applied stairs double-sided shear wall demonstrate its practicability.

Язык: Английский

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The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Июнь 1, 2020

Abstract How do brain mechanisms create maladaptive attractions? Here intense attractions are created in laboratory rats by pairing optogenetic channelrhodopsin (ChR2) stimulation of central nucleus amygdala (CeA) with encountering either sucrose, cocaine, or a painful shock-delivering object. We find that pairings make the respective pursue sucrose exclusively, cocaine repeatedly self-inflict shocks. CeA-induced attractions, even to shock-rod, recruit mesocorticolimbic incentive-related circuitry. Shock-associated cues also gain positive incentive value and pursued. Yet motivational effects paired CeA can be reversed negative valence Pavlovian fear learning situation, where ChR2 increases defensive reactions. Finally, switched neutral innocuous stimuli. These results reveal plasticity multiple modes for motivation via circuitry under control activation.

Язык: Английский

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Neural modulation of social reinforcement learning by intranasal oxytocin in male adults with high-functioning autism spectrum disorder: a randomized trial

Neuropsychopharmacology, Год журнала: 2018, Номер 44(4), С. 749 - 756

Опубликована: Ноя. 2, 2018

Язык: Английский

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