Socioeconomic disadvantage, gestational immune activity, and neurodevelopment in early childhood DOI Open Access
Stephen E. Gilman, Mady Hornig, Akhgar Ghassabian

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2017, Номер 114(26), С. 6728 - 6733

Опубликована: Июнь 12, 2017

Significance Children raised in economically disadvantaged households face increased risks of poor health adulthood, suggesting early origins socioeconomic inequalities health. In fact, maternal immune activity response to stressful conditions during pregnancy has been found play a key role fetal brain development. Here we show that disadvantage is associated with lower concentrations the pro-inflammatory cytokine IL-8 third trimester and, turn, offspring’s neurologic abnormalities first year life. These results suggest stress–immune mechanisms as one potential pathophysiologic pathway involved population inequalities.

Язык: Английский

Hemochorial placentation: development, function, and adaptations† DOI Open Access
Michael J. Soares, Kaela M. Varberg, Khursheed Iqbal

и другие.

Biology of Reproduction, Год журнала: 2018, Номер 99(1), С. 196 - 211

Опубликована: Фев. 22, 2018

Placentation is a reproductive adaptation that permits fetal growth and development within the protected confines of female tract. Through this important role, placenta also determines postnatal health susceptibility to disease. The hemochorial prominent feature in primate rodent development. This manuscript provides an overview basics placental function, perspectives on major discoveries have shaped research, thoughts strategies for future investigation.

Язык: Английский

Процитировано

170

The Pivotal Role of the Placenta in Normal and Pathological Pregnancies: A Focus on Preeclampsia, Fetal Growth Restriction, and Maternal Chronic Venous Disease DOI Creative Commons
Miguel Á. Ortega, Oscar Fraile‐Martínez, Cielo García‐Montero

и другие.

Cells, Год журнала: 2022, Номер 11(3), С. 568 - 568

Опубликована: Фев. 6, 2022

The placenta is a central structure in pregnancy and has pleiotropic functions. This organ grows incredibly rapidly during this period, acting as mastermind behind different fetal maternal processes. relevance of the extends far beyond pregnancy, being crucial for programming before birth. Having integrative knowledge maternofetal helps significantly understanding development either proper or pathophysiological context. Thus, aim review to summarize main features placenta, with special focus on its early development, cytoarchitecture, immunology, functions non-pathological conditions. In contraposition, role examined preeclampsia, worrisome hypertensive disorder order describe implications disease. Likewise, dysfunction growth restriction, major consequence also discussed, emphasizing potential clinical strategies derived. Finally, emerging chronic venous disease causative agent equally treated.

Язык: Английский

Процитировано

87

Perinatal Maternal Depressive Symptoms as an Issue for Population Health DOI Open Access
Michael J. Meaney

American Journal of Psychiatry, Год журнала: 2018, Номер 175(11), С. 1084 - 1093

Опубликована: Авг. 2, 2018

The importance of maternal depression for child outcomes is well established, and impairments in psychosocial function parenting are as severe women with high subsyndromal levels depressive symptoms they clinical depression. author conducted a systematic review that explored the association between neurodevelopmental outcomes, including neuroimaging studies. results strongly suggest influences operate across continuum to influence implying may appropriately be considered an issue population health. This conclusion strengthened by recent findings reveal distinct positive mental health on outcomes. [AJP AT 175: Remembering Our Past As We Envision Future April 1851: Fleetwood Churchill, "On Mental Disorders Pregnancy Childbed" "Women affected any degree derangement during pregnancy more disposed than others puerperal mania. But serious character these attacks even deepened fact, abundantly evil not limited mother. Not only organic diseases body transmitted infant, but predisposition insanity, thus multiplying distress most alarming ratio." (Am J Psychiatry 1851; 7:297-317 )].

Язык: Английский

Процитировано

161

SExual Epigenetic Dimorphism in The Human Placenta: Implications for Susceptibility During The Prenatal Period DOI
Elizabeth M. Martin, Lisa Smeester, Paige A. Bommarito

и другие.

Epigenomics, Год журнала: 2017, Номер 9(3), С. 267 - 278

Опубликована: Фев. 17, 2017

Sex-based differences in response to adverse prenatal environments and infant outcomes have been observed, yet the underlying mechanisms for this are unclear. The placental epigenome may be a driver of these differences.

Язык: Английский

Процитировано

115

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns DOI Creative Commons
Darina Czamara, Gökçen Eraslan, Christian M. Page

и другие.

Nature Communications, Год журнала: 2019, Номер 10(1)

Опубликована: Июнь 11, 2019

Abstract Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either or contributions DNAm, few assessed their integrated effects. Here we examine relative prenatal genotype on in neonatal blood at variably methylated regions (VMRs) 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion test which best explain variability cohort-specific VMRs: several (E), genotypes cis (G), additive (G + E) interaction (GxE) Genetic combination DNAm majority VMRs. The CpGs explained by G, G E GxE functionally distinct. enrichment variants from models GWAS for complex disorders supports importance disease risk.

Язык: Английский

Процитировано

111

Maternal prenatal stress and infant DNA methylation: A systematic review DOI Open Access

David W. Sosnowski,

Carolyn Booth,

Timothy P. York

и другие.

Developmental Psychobiology, Год журнала: 2018, Номер 60(2), С. 127 - 139

Опубликована: Янв. 18, 2018

Abstract Maternal prenatal stress has been linked to a variety of infant postnatal outcomes, partially through alterations in fetal HPA axis functioning; yet the underlying pathobiology remains elusive. Current literature posits DNA methylation as candidate mechanism which maternal can influence functioning. The goal this systematic review was summarize examining associations among stress, commonly studied genes, and Results from provided evidence for link between various stressors, NR3C1 methylation, reactivity, but findings other genes were limited, with mixed results. An original study quality tool revealed that majority studies are adequate, emphasizes need future research consider when interpreting findings.

Язык: Английский

Процитировано

105

Diet: the keystone of autism spectrum disorder? DOI
Sara Peretti, MSLT Rita G. Mariano,

Chiara Mazzocchetti

и другие.

Nutritional Neuroscience, Год журнала: 2018, Номер 22(12), С. 825 - 839

Опубликована: Апрель 19, 2018

Children with autism are characterized by an impairment of social interaction and repetitive patterns behaviour. Autism is a heterogeneous span disorders unknown aetiology. Research has grown significantly suggested that environmental risk factors acting during the prenatal period could influence neurodevelopment offspring. The literature suggests maternal diet pregnancy fundamental role in etiopathogenesis autism. Indeed, high some nutrients been associated increase or reduction develop Spectrum Disorders (ASD). ASD children also key factor for worsening symptoms. have food selectivity limited diets due to smell, taste, other characteristics foods. This determines eating routines intake patterns, consequent deficiency excess aliments. Several studies tried show possible relationship between nutritional status In this review we describe, emphasizing limits benefits, main current empirical examined gestation as modifiable at base development symptoms

Язык: Английский

Процитировано

95

Integrating Ecological and Evolutionary Context in the Study of Maternal Stress DOI Open Access
Michael J. Sheriff, Alison M. Bell, Rudy Boonstra

и другие.

Integrative and Comparative Biology, Год журнала: 2017, Номер 57(3), С. 437 - 449

Опубликована: Июль 10, 2017

Maternal stress can prenatally influence offspring phenotypes and there are an increasing number of ecological studies that bringing to bear biomedical findings natural systems. This is resulting in a shift from the perspective maternal unanimously costly, one which may be beneficial offspring. However, this adaptive its infancy with much progress still made understanding role Our aim emphasize importance evolutionary context within hypotheses evaluated. We present five primary research areas where we think future make substantial progress: (1) control mechanisms modulate exposure between subsequent phenotype response; (2) dynamic nature interaction mothers their environment; (3) integrating phenotypic responses measuring both fitness outcomes under real-life (either free-living or semi-natural) conditions; (4) empirically testing these across relevant spatial temporal environmental contexts (both pre- post-natal environments); (5) examining effects human-altered environments-i.e., do they limit enhance fitness. To progress, it critical understand that, must integrate physiology, behavior, genetics, evolution.

Язык: Английский

Процитировано

89

Environmental Mechanisms of Neurodevelopmental Toxicity DOI
Kylie D. Rock, Heather B. Patisaul

Current Environmental Health Reports, Год журнала: 2018, Номер 5(1), С. 145 - 157

Опубликована: Март 1, 2018

Язык: Английский

Процитировано

88

Placental programming of neuropsychiatric disease DOI Open Access
Panagiotis Kratimenos, Anna A. Penn

Pediatric Research, Год журнала: 2019, Номер 86(2), С. 157 - 164

Опубликована: Апрель 19, 2019

Язык: Английский

Процитировано

82