Proceedings of the National Academy of Sciences,
Год журнала:
2017,
Номер
114(26), С. 6728 - 6733
Опубликована: Июнь 12, 2017
Significance
Children
raised
in
economically
disadvantaged
households
face
increased
risks
of
poor
health
adulthood,
suggesting
early
origins
socioeconomic
inequalities
health.
In
fact,
maternal
immune
activity
response
to
stressful
conditions
during
pregnancy
has
been
found
play
a
key
role
fetal
brain
development.
Here
we
show
that
disadvantage
is
associated
with
lower
concentrations
the
pro-inflammatory
cytokine
IL-8
third
trimester
and,
turn,
offspring’s
neurologic
abnormalities
first
year
life.
These
results
suggest
stress–immune
mechanisms
as
one
potential
pathophysiologic
pathway
involved
population
inequalities.
Biology of Reproduction,
Год журнала:
2018,
Номер
99(1), С. 196 - 211
Опубликована: Фев. 22, 2018
Placentation
is
a
reproductive
adaptation
that
permits
fetal
growth
and
development
within
the
protected
confines
of
female
tract.
Through
this
important
role,
placenta
also
determines
postnatal
health
susceptibility
to
disease.
The
hemochorial
prominent
feature
in
primate
rodent
development.
This
manuscript
provides
an
overview
basics
placental
function,
perspectives
on
major
discoveries
have
shaped
research,
thoughts
strategies
for
future
investigation.
Cells,
Год журнала:
2022,
Номер
11(3), С. 568 - 568
Опубликована: Фев. 6, 2022
The
placenta
is
a
central
structure
in
pregnancy
and
has
pleiotropic
functions.
This
organ
grows
incredibly
rapidly
during
this
period,
acting
as
mastermind
behind
different
fetal
maternal
processes.
relevance
of
the
extends
far
beyond
pregnancy,
being
crucial
for
programming
before
birth.
Having
integrative
knowledge
maternofetal
helps
significantly
understanding
development
either
proper
or
pathophysiological
context.
Thus,
aim
review
to
summarize
main
features
placenta,
with
special
focus
on
its
early
development,
cytoarchitecture,
immunology,
functions
non-pathological
conditions.
In
contraposition,
role
examined
preeclampsia,
worrisome
hypertensive
disorder
order
describe
implications
disease.
Likewise,
dysfunction
growth
restriction,
major
consequence
also
discussed,
emphasizing
potential
clinical
strategies
derived.
Finally,
emerging
chronic
venous
disease
causative
agent
equally
treated.
American Journal of Psychiatry,
Год журнала:
2018,
Номер
175(11), С. 1084 - 1093
Опубликована: Авг. 2, 2018
The
importance
of
maternal
depression
for
child
outcomes
is
well
established,
and
impairments
in
psychosocial
function
parenting
are
as
severe
women
with
high
subsyndromal
levels
depressive
symptoms
they
clinical
depression.
author
conducted
a
systematic
review
that
explored
the
association
between
neurodevelopmental
outcomes,
including
neuroimaging
studies.
results
strongly
suggest
influences
operate
across
continuum
to
influence
implying
may
appropriately
be
considered
an
issue
population
health.
This
conclusion
strengthened
by
recent
findings
reveal
distinct
positive
mental
health
on
outcomes.
[AJP
AT
175:
Remembering
Our
Past
As
We
Envision
Future
April
1851:
Fleetwood
Churchill,
"On
Mental
Disorders
Pregnancy
Childbed"
"Women
affected
any
degree
derangement
during
pregnancy
more
disposed
than
others
puerperal
mania.
But
serious
character
these
attacks
even
deepened
fact,
abundantly
evil
not
limited
mother.
Not
only
organic
diseases
body
transmitted
infant,
but
predisposition
insanity,
thus
multiplying
distress
most
alarming
ratio."
(Am
J
Psychiatry
1851;
7:297-317
)].
Epigenomics,
Год журнала:
2017,
Номер
9(3), С. 267 - 278
Опубликована: Фев. 17, 2017
Sex-based
differences
in
response
to
adverse
prenatal
environments
and
infant
outcomes
have
been
observed,
yet
the
underlying
mechanisms
for
this
are
unclear.
The
placental
epigenome
may
be
a
driver
of
these
differences.
Nature Communications,
Год журнала:
2019,
Номер
10(1)
Опубликована: Июнь 11, 2019
Abstract
Epigenetic
processes,
including
DNA
methylation
(DNAm),
are
among
the
mechanisms
allowing
integration
of
genetic
and
environmental
factors
to
shape
cellular
function.
While
many
studies
have
investigated
either
or
contributions
DNAm,
few
assessed
their
integrated
effects.
Here
we
examine
relative
prenatal
genotype
on
in
neonatal
blood
at
variably
methylated
regions
(VMRs)
4
independent
cohorts
(overall
n
=
2365).
We
use
Akaike’s
information
criterion
test
which
best
explain
variability
cohort-specific
VMRs:
several
(E),
genotypes
cis
(G),
additive
(G
+
E)
interaction
(GxE)
Genetic
combination
DNAm
majority
VMRs.
The
CpGs
explained
by
G,
G
E
GxE
functionally
distinct.
enrichment
variants
from
models
GWAS
for
complex
disorders
supports
importance
disease
risk.
Developmental Psychobiology,
Год журнала:
2018,
Номер
60(2), С. 127 - 139
Опубликована: Янв. 18, 2018
Abstract
Maternal
prenatal
stress
has
been
linked
to
a
variety
of
infant
postnatal
outcomes,
partially
through
alterations
in
fetal
HPA
axis
functioning;
yet
the
underlying
pathobiology
remains
elusive.
Current
literature
posits
DNA
methylation
as
candidate
mechanism
which
maternal
can
influence
functioning.
The
goal
this
systematic
review
was
summarize
examining
associations
among
stress,
commonly
studied
genes,
and
Results
from
provided
evidence
for
link
between
various
stressors,
NR3C1
methylation,
reactivity,
but
findings
other
genes
were
limited,
with
mixed
results.
An
original
study
quality
tool
revealed
that
majority
studies
are
adequate,
emphasizes
need
future
research
consider
when
interpreting
findings.
Nutritional Neuroscience,
Год журнала:
2018,
Номер
22(12), С. 825 - 839
Опубликована: Апрель 19, 2018
Children
with
autism
are
characterized
by
an
impairment
of
social
interaction
and
repetitive
patterns
behaviour.
Autism
is
a
heterogeneous
span
disorders
unknown
aetiology.
Research
has
grown
significantly
suggested
that
environmental
risk
factors
acting
during
the
prenatal
period
could
influence
neurodevelopment
offspring.
The
literature
suggests
maternal
diet
pregnancy
fundamental
role
in
etiopathogenesis
autism.
Indeed,
high
some
nutrients
been
associated
increase
or
reduction
develop
Spectrum
Disorders
(ASD).
ASD
children
also
key
factor
for
worsening
symptoms.
have
food
selectivity
limited
diets
due
to
smell,
taste,
other
characteristics
foods.
This
determines
eating
routines
intake
patterns,
consequent
deficiency
excess
aliments.
Several
studies
tried
show
possible
relationship
between
nutritional
status
In
this
review
we
describe,
emphasizing
limits
benefits,
main
current
empirical
examined
gestation
as
modifiable
at
base
development
symptoms
Integrative and Comparative Biology,
Год журнала:
2017,
Номер
57(3), С. 437 - 449
Опубликована: Июль 10, 2017
Maternal
stress
can
prenatally
influence
offspring
phenotypes
and
there
are
an
increasing
number
of
ecological
studies
that
bringing
to
bear
biomedical
findings
natural
systems.
This
is
resulting
in
a
shift
from
the
perspective
maternal
unanimously
costly,
one
which
may
be
beneficial
offspring.
However,
this
adaptive
its
infancy
with
much
progress
still
made
understanding
role
Our
aim
emphasize
importance
evolutionary
context
within
hypotheses
evaluated.
We
present
five
primary
research
areas
where
we
think
future
make
substantial
progress:
(1)
control
mechanisms
modulate
exposure
between
subsequent
phenotype
response;
(2)
dynamic
nature
interaction
mothers
their
environment;
(3)
integrating
phenotypic
responses
measuring
both
fitness
outcomes
under
real-life
(either
free-living
or
semi-natural)
conditions;
(4)
empirically
testing
these
across
relevant
spatial
temporal
environmental
contexts
(both
pre-
post-natal
environments);
(5)
examining
effects
human-altered
environments-i.e.,
do
they
limit
enhance
fitness.
To
progress,
it
critical
understand
that,
must
integrate
physiology,
behavior,
genetics,
evolution.