Neuropsychopharmacology, Год журнала: 2024, Номер 49(9), С. 1417 - 1424
Опубликована: Март 11, 2024
Язык: Английский
Educational Psychologist, Год журнала: 2019, Номер 54(3), С. 185 - 204
Опубликована: Июль 3, 2019
New advances in neurobiology are revealing that brain development and the learning it enables directly dependent on social-emotional experience. Growing bodies of research reveal importance socially triggered epigenetic contributions to network configuration, with implications for functioning, cognition, motivation, learning. Brain is also impacted by health-related physical developmental factors, such as sleep, toxin exposure, puberty, which turn influence functioning cognition. An appreciation dynamic interdependencies experience, underscores a "whole child" approach education reform leads important insights To facilitate these interdisciplinary conversations, here we conceptualize within framework current evidence fundamental ubiquitous biological constraints affordances undergirding learning–related constructs more broadly. Learning indeed depends how nature nurtured.
Язык: Английский
Процитировано
210
Journal of Neuroscience, Год журнала: 2019, Номер 39(42), С. 8250 - 8258
Опубликована: Окт. 16, 2019
The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women adolescents. Epidemiological studies have long demonstrated a relationship between developmental exposure later mental health symptoms. This is especially strong people with particular genetic polymorphisms, suggesting that interacts genotype to increase risk. Seminal animal research directly linked prenatal adolescent delta-9-tetrahydrocannabinol, major psychoactive component cannabis, protracted effects adult neural systems relevant psychiatric substance disorders. In this article, we discuss some advances understanding long-term molecular, epigenetic, electrophysiological, behavioral consequences prenatal, perinatal, cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both human studies, including vivo neuroimaging strategies.
Язык: Английский
Процитировано
187
Nature reviews. Neuroscience, Год журнала: 2021, Номер 22(7), С. 423 - 438
Опубликована: Май 21, 2021
Язык: Английский
Процитировано
150
JAMA Psychiatry, Год журнала: 2021, Номер 78(9), С. 1031 - 1031
Опубликована: Июнь 16, 2021
Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting altered neurodevelopment and lasting behavioral effects. However, few investigated ties between cannabis use development humans.
Язык: Английский
Процитировано
123
Redox Biology, Год журнала: 2025, Номер 80, С. 103491 - 103491
Опубликована: Янв. 8, 2025
Adolescent depression is a globally concerned mental health issue, the pathophysiological mechanisms of which remain elusive. Membrane lipids play crucial role in brain development and function, potentially serving as crossroad for abnormalities neurotransmitters, neuroendocrine, inflammation, oxidative stress, energy metabolism observed depressed adolescents. The primary aim this study was to investigate erythrocyte membrane lipid profile adolescent depression. A total 2838 were detected quantified 81 adolescents with 67 matched healthy using ultra-high performance liquid chromatography-mass spectrometry. Depressed exhibited significantly different characteristics compared controls. Specifically, levels cholesterol, sphingomyelins, ceramides increased, while ether decreased patients. Moreover, patients showed reduced polyunsaturated fatty acids elevated lipophilic index membrane, suggesting diminished fluidity. higher oxidized plasma malondialdehyde depression, indicating presence stress. Importantly, damage associated more severe depressive symptoms worse cognitive function In addition, fluidity may be partly responsible blunted niacin skin flushing response found conclusion, our results reveal impaired homeostasis implicate dysfunction brain. These findings offer new insights into underlying molecular highlighting potential counteracting promising avenue future therapeutic interventions.
Язык: Английский
Процитировано
3
Scientific Reports, Год журнала: 2019, Номер 9(1)
Опубликована: Ноя. 5, 2019
Abstract We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling. The CBs, Δ 9 -THC, cannabidiol, HU-210, CP 55,940 caused alcohol-like effects craniofacial brain development, phenocopying Shh mutations. Combined exposure to even low doses of alcohol with THC, or a greater incidence defects, particularly eyes, than did either treatment alone. Consistent hypothesis that these are by deficient Shh, we found CBs reduced signaling inhibiting Smoothened (Smo), while mRNA CB1 receptor antagonist attenuated CB-induced defects. Proximity ligation experiments identified novel CB1-Smo heteromers, suggesting allosteric interactions. In addition raising concerns about safety cannabinoid during early embryonic this study establishes link between two distinct pathways has widespread implications for as well diseases such addiction cancer.
Язык: Английский
Процитировано
99
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5251 - 5251
Опубликована: Март 9, 2023
Cannabis is the most used drug of abuse worldwide. It well established that abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). These two compounds have remarkably similar chemical structures yet vastly different effects brain. By binding to same receptors, THC psychoactive, while CBD has anxiolytic antipsychotic properties. Lately, a variety hemp-based products, including THC, become widely available food health industry, medical recreational use cannabis been legalized many states/countries. As result, people, youths, consuming because it considered “safe”. An extensive literature exists evaluating harmful both adults adolescents, but little known about long-term exposure, especially adolescence. The aim review collect preclinical clinical evidence cannabidiol.
Язык: Английский
Процитировано
28
Biochemical Pharmacology, Год журнала: 2018, Номер 157, С. 97 - 107
Опубликована: Июль 17, 2018
Язык: Английский
Процитировано
73
Translational Psychiatry, Год журнала: 2020, Номер 10(1)
Опубликована: Май 19, 2020
Abstract Beyond being one the most widely used psychoactive drugs in world, cannabis has been identified as an environmental risk factor for psychosis. Though relationship between use and psychiatric disorders remains controversial, consistent association early adolescent subsequent of psychosis suggested adolescence may be a particularly vulnerable period. Previous findings on gene by environment interactions indicated that only increase subjects who have specific genetic vulnerability. The type 1 cannabinoid receptor (CB1), encoded CNR1 gene, is key component endocannabinoid system. As primary brain, CB1 main molecular target ligand, well tetrahydrocannabinol (THC), principal ingredient cannabis. In this study, we examined mRNA expression DNA methylation human prefrontal cortex (PFC), hippocampus, caudate samples. higher fetal PFC then drops down dramatically after birth. lifespan trajectory DLPFC differentially correlated with age allelic variation at rs4680, functional polymorphism COMT gene. Compared methionine 158 carriers, Caucasian carriers valine allele stronger negative correlation age. contrast, level cg02498983, which negatively PFC, showed strongest positive . Additionally, observed decreased patients schizophrenia. Further analysis revealed eQTL SNP, rs806368, predicted novel transcript DLPFC, hippocampus caudate. This SNP associated addiction other disorders. THC or ethanol are each significantly dysregulated affective disorder, upregulated schizophrenia completed suicide. Our results support previous studies implicated system pathology provided additional insight into mechanism increasing users.
Язык: Английский
Процитировано
67
Psychiatric Clinics of North America, Год журнала: 2020, Номер 43(2), С. 263 - 274
Опубликована: Апрель 22, 2020
Язык: Английский
Процитировано
61