Measuring white matter microstructure in 1,457 cannabis users and 1,441 controls: A systematic review of diffusion-weighted MRI studies DOI Creative Commons
Emily Robinson, John Gleeson, Arush Honnedevasthana Arun

et al.

Frontiers in Neuroimaging, Journal Year: 2023, Volume and Issue: 2

Published: March 7, 2023

Cannabis is the most widely used regulated substance by youth and adults. use has been associated with psychosocial problems, which have partly ascribed to neurobiological changes. Emerging evidence date from diffusion-MRI studies shows that cannabis users compared controls show poorer integrity of white matter fibre tracts, structurally connect distinct brain regions facilitate neural communication. However, recent thus far yet be integrated. Therefore, it unclear if differences in are evident consistently selected locations, specific metrics, whether these metrics exposure levels.We systematically reviewed results imaging between controls. We also examined associations other behavioral variables due changes matter. Our review was pre-registered PROSPERO (ID: 258250; https://www.crd.york.ac.uk/prospero/).We identified 30 including 1,457 1,441 aged 16-to-45 years. All but 6 reported group integrity. The consistent were lower fractional anisotropy within arcuate/superior longitudinal fasciculus (7 studies), corpus callosum (6 studies) as well higher mean diffusivity trace (4 studies). Differences onset especially (3 studies).The mechanisms underscoring unclear, they may include effects during youth, neurotoxic or neuro adaptations regular tetrahydrocannabinol (THC), exerts its binding receptors, a vulnerability predating use. Future multimodal neuroimaging studies, recently developed advanced can track over time define precision when region commence users, cessation recovers differences.www.crd.york.ac.uk/prospero/, identifier: 258250.

Language: Английский

Nurturing Nature: How Brain Development Is Inherently Social and Emotional, and What This Means for Education DOI Creative Commons
Mary Helen Immordino‐Yang, Linda Darling‐Hammond,

Christina Krone

et al.

Educational Psychologist, Journal Year: 2019, Volume and Issue: 54(3), P. 185 - 204

Published: July 3, 2019

New advances in neurobiology are revealing that brain development and the learning it enables directly dependent on social-emotional experience. Growing bodies of research reveal importance socially triggered epigenetic contributions to network configuration, with implications for functioning, cognition, motivation, learning. Brain is also impacted by health-related physical developmental factors, such as sleep, toxin exposure, puberty, which turn influence functioning cognition. An appreciation dynamic interdependencies experience, underscores a "whole child" approach education reform leads important insights To facilitate these interdisciplinary conversations, here we conceptualize within framework current evidence fundamental ubiquitous biological constraints affordances undergirding learning–related constructs more broadly. Learning indeed depends how nature nurtured.

Language: Английский

Citations

207
Cannabis and the Developing Brain: Insights into Its Long-Lasting Effects DOI Creative Commons
Yasmin L. Hurd, Olivier J. Manzoni, Mikhail V. Pletnikov

et al.

Journal of Neuroscience, Journal Year: 2019, Volume and Issue: 39(42), P. 8250 - 8258

Published: Oct. 16, 2019

The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women adolescents. Epidemiological studies have long demonstrated a relationship between developmental exposure later mental health symptoms. This is especially strong people with particular genetic polymorphisms, suggesting that interacts genotype to increase risk. Seminal animal research directly linked prenatal adolescent delta-9-tetrahydrocannabinol, major psychoactive component cannabis, protracted effects adult neural systems relevant psychiatric substance disorders. In this article, we discuss some advances understanding long-term molecular, epigenetic, electrophysiological, behavioral consequences prenatal, perinatal, cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both human studies, including vivo neuroimaging strategies.

Language: Английский

Citations

184
Cannabis and synaptic reprogramming of the developing brain DOI
Anissa Bara, Jacqueline‐Marie N. Ferland,

Gregory Rompala

et al.

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(7), P. 423 - 438

Published: May 21, 2021

Language: Английский

Citations

143
Association of Cannabis Use During Adolescence With Neurodevelopment DOI Creative Commons
Matthew D. Albaugh, Jonatan Ottino‐González,

Amanda B. Sidwell

et al.

JAMA Psychiatry, Journal Year: 2021, Volume and Issue: 78(9), P. 1031 - 1031

Published: June 16, 2021

Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting altered neurodevelopment and lasting behavioral effects. However, few investigated ties between cannabis use development humans.

Language: Английский

Citations

117
Impaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression DOI Creative Commons
Jinfeng Wang, Xiaowen Hu, Ya Li

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: 80, P. 103491 - 103491

Published: Jan. 8, 2025

Adolescent depression is a globally concerned mental health issue, the pathophysiological mechanisms of which remain elusive. Membrane lipids play crucial role in brain development and function, potentially serving as crossroad for abnormalities neurotransmitters, neuroendocrine, inflammation, oxidative stress, energy metabolism observed depressed adolescents. The primary aim this study was to investigate erythrocyte membrane lipid profile adolescent depression. A total 2838 were detected quantified 81 adolescents with 67 matched healthy using ultra-high performance liquid chromatography-mass spectrometry. Depressed exhibited significantly different characteristics compared controls. Specifically, levels cholesterol, sphingomyelins, ceramides increased, while ether decreased patients. Moreover, patients showed reduced polyunsaturated fatty acids elevated lipophilic index membrane, suggesting diminished fluidity. higher oxidized plasma malondialdehyde depression, indicating presence stress. Importantly, damage associated more severe depressive symptoms worse cognitive function In addition, fluidity may be partly responsible blunted niacin skin flushing response found conclusion, our results reveal impaired homeostasis implicate dysfunction brain. These findings offer new insights into underlying molecular highlighting potential counteracting promising avenue future therapeutic interventions.

Language: Английский

Citations

2
Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction DOI Creative Commons
Eric W. Fish, Laura B. Murdaugh, Chengjin Zhang

et al.

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: Nov. 5, 2019

Abstract We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling. The CBs, Δ 9 -THC, cannabidiol, HU-210, CP 55,940 caused alcohol-like effects craniofacial brain development, phenocopying Shh mutations. Combined exposure to even low doses of alcohol with THC, or a greater incidence defects, particularly eyes, than did either treatment alone. Consistent hypothesis that these are by deficient Shh, we found CBs reduced signaling inhibiting Smoothened (Smo), while mRNA CB1 receptor antagonist attenuated CB-induced defects. Proximity ligation experiments identified novel CB1-Smo heteromers, suggesting allosteric interactions. In addition raising concerns about safety cannabinoid during early embryonic this study establishes link between two distinct pathways has widespread implications for as well diseases such addiction cancer.

Language: Английский

Citations

99
THC and CBD: Villain versus Hero? Insights into Adolescent Exposure DOI Open Access
Nicholas Pintori,

Francesca Caria,

Maria Antonietta De Luca

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5251 - 5251

Published: March 9, 2023

Cannabis is the most used drug of abuse worldwide. It well established that abundant phytocannabinoids in this plant are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). These two compounds have remarkably similar chemical structures yet vastly different effects brain. By binding to same receptors, THC psychoactive, while CBD has anxiolytic antipsychotic properties. Lately, a variety hemp-based products, including THC, become widely available food health industry, medical recreational use cannabis been legalized many states/countries. As result, people, youths, consuming because it considered “safe”. An extensive literature exists evaluating harmful both adults adolescents, but little known about long-term exposure, especially adolescence. The aim review collect preclinical clinical evidence cannabidiol.

Language: Английский

Citations

28
The endocannabinoid system in mental disorders: Evidence from human brain studies DOI
Inés Ibarra‐Lecue, Fuencisla Pilar-Cuéllar, Carolina Muguruza

et al.

Biochemical Pharmacology, Journal Year: 2018, Volume and Issue: 157, P. 97 - 107

Published: July 17, 2018

Language: Английский

Citations

73
Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia DOI Creative Commons
Ran Tao, Chao Li, Andrew E. Jaffe

et al.

Translational Psychiatry, Journal Year: 2020, Volume and Issue: 10(1)

Published: May 19, 2020

Abstract Beyond being one the most widely used psychoactive drugs in world, cannabis has been identified as an environmental risk factor for psychosis. Though relationship between use and psychiatric disorders remains controversial, consistent association early adolescent subsequent of psychosis suggested adolescence may be a particularly vulnerable period. Previous findings on gene by environment interactions indicated that only increase subjects who have specific genetic vulnerability. The type 1 cannabinoid receptor (CB1), encoded CNR1 gene, is key component endocannabinoid system. As primary brain, CB1 main molecular target ligand, well tetrahydrocannabinol (THC), principal ingredient cannabis. In this study, we examined mRNA expression DNA methylation human prefrontal cortex (PFC), hippocampus, caudate samples. higher fetal PFC then drops down dramatically after birth. lifespan trajectory DLPFC differentially correlated with age allelic variation at rs4680, functional polymorphism COMT gene. Compared methionine 158 carriers, Caucasian carriers valine allele stronger negative correlation age. contrast, level cg02498983, which negatively PFC, showed strongest positive . Additionally, observed decreased patients schizophrenia. Further analysis revealed eQTL SNP, rs806368, predicted novel transcript DLPFC, hippocampus caudate. This SNP associated addiction other disorders. THC or ethanol are each significantly dysregulated affective disorder, upregulated schizophrenia completed suicide. Our results support previous studies implicated system pathology provided additional insight into mechanism increasing users.

Language: Английский

Citations

66
Neurodevelopmental Factors in Schizophrenia DOI
Hanna Jaaro-Peled, Akira Sawa

Psychiatric Clinics of North America, Journal Year: 2020, Volume and Issue: 43(2), P. 263 - 274

Published: April 22, 2020

Language: Английский

Citations

60