Cannabis use and cannabis use disorder

Nature Reviews Disease Primers, Год журнала: 2021, Номер 7(1)

Опубликована: Фев. 25, 2021

Язык: Английский

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Astroglial CB1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory

Neuron, Год журнала: 2018, Номер 98(5), С. 935 - 944.e5

Опубликована: Май 17, 2018

Язык: Английский

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Glucose metabolism links astroglial mitochondria to cannabinoid effects

Nature, Год журнала: 2020, Номер 583(7817), С. 603 - 608

Опубликована: Июль 8, 2020

Язык: Английский

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Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder

Neuropsychopharmacology, Год журнала: 2017, Номер 43(1), С. 80 - 102

Опубликована: Июль 26, 2017

Язык: Английский

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G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

Neuroscience, Год журнала: 2020, Номер 456, С. 71 - 84

Опубликована: Март 26, 2020

Язык: Английский

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G protein-coupled receptors (GPCRs): advances in structures, mechanisms and drug discovery

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Апрель 9, 2024

Abstract G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects allosteric effects, biased signaling balanced signaling, characterize complexity GPCR dynamic features. In this study, we first review structural advancements, activation mechanisms, functional diversity GPCRs. We then focus on discovery by revealing detailed drug-target interactions underlying mechanisms drugs approved US Food Drug Administration past five years. Particularly, up-to-date analysis is performed available structures complexed with synthetic small-molecule modulators to elucidate key receptor-ligand mechanisms. Finally, highlight how widespread GPCR-druggable sites can guide structure- mechanism-based design propose prospects designing bitopic ligands for future therapeutic potential targeting receptor family.

Язык: Английский

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THC and CBD: Similarities and differences between siblings

Neuron, Год журнала: 2023, Номер 111(3), С. 302 - 327

Опубликована: Янв. 12, 2023

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Molecular basis underlying default mode network functional abnormalities in postpartum depression with and without anxiety

Human Brain Mapping, Год журнала: 2024, Номер 45(5)

Опубликована: Март 28, 2024

Abstract Although Postpartum depression (PPD) and PPD with anxiety (PPD‐A) have been well characterized as functional disruptions within or between multiple brain systems, however, how to quantitatively delineate system irregularity the molecular basis of abnormalities in PPD‐A remains unclear. Here, sample entropy (SampEn), resting‐state connectivity (RSFC), transcriptomic neurotransmitter density data were used investigate irregularity, associated for PPD‐A. exhibited higher SampEn medial prefrontal cortex (MPFC) posterior cingulate (PPC) than healthy postnatal women (HPW) while showed lower PPC compared HPW The analysis MPFC seed areas revealed decreased couplings PCC paracentral lobule angular gyrus both HPW. Moreover, abnormal estrogenic level clinical symptoms load. Importantly, spatial association analyses changes transcriptome maps that these primarily synaptic signaling, neuron projection, regulation, amino acid metabolism, cyclic adenosine monophosphate (cAMP) signaling pathways, neurotransmitters 5‐hydroxytryptamine (5‐HT), norepinephrine, glutamate, dopamine so on. These results reveal connectivities default mode network (DMN) link establish first time. Our findings highlight important role DMN neuropathology

Язык: Английский

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Protective Effects of (E)-β-Caryophyllene (BCP) in Chronic Inflammation

Nutrients, Год журнала: 2020, Номер 12(11), С. 3273 - 3273

Опубликована: Окт. 26, 2020

(E)-β-caryophyllene (BCP) is a bicyclic sesquiterpene widely distributed in the plant kingdom, where it contributes unique aroma to essential oils and has pivotal role survival evolution of higher plants. Recent studies provided evidence for protective roles BCP animal cells, highlighting its possible use as novel therapeutic tool. Experimental results show ability reduce pro-inflammatory mediators such tumor necrosis factor-alfa (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB), thus ameliorating chronic pathologies characterized by inflammation oxidative stress, particular metabolic neurological diseases. Through binding CB2 cannabinoid receptors interaction with members family peroxisome proliferator-activated (PPARs), shows beneficial effects on obesity, non-alcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) diseases, diabetes, cardiovascular pain other nervous system disorders. This review describes current knowledge biosynthesis natural sources BCP, reviews mechanisms action different inflammation-related neurologic

Язык: Английский

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Endocannabinoid System Components as Potential Biomarkers in Psychiatry

Frontiers in Psychiatry, Год журнала: 2020, Номер 11

Опубликована: Апрель 27, 2020

The high heterogeneity of psychiatric disorders, leads to a lack diagnostic precision. Therefore, the search biomarkers is fundamental aspect in psychiatry reach more personalized medicine. endocannabinoid system (ECS) has gained increasing interest due its involvement many different functional processes brain, including regulation emotions, motivation and cognition. This article reviews role main components ECS as certain disorders. Studies carried out rodents evaluating effects pharmacological genetic manipulation cannabinoid receptors or endocannabinoids (eCBs) degrading enzymes. Likewise, ECS-related alterations occurring at molecular level animal models reproducing some behavioral and/or neuropathological aspects disorders were reviewed. Clinical studies gene protein post-mortem brain tissue vivo blood, plasma cerebrospinal fluid (CSF) samples analyzed. Furthermore, results from neuroimaging using positron emission tomography (PET) magnetic resonance (fMRI) included. review shows close receptor 1 (CB1r) stress development mood (anxiety, depression, bipolar disorder (BD)), post-traumatic (PTSD), well etiopathogenesis schizophrenia, attention deficit hyperactivity (ADHD) eating (i.e. anorexia bulimia nervosa). On other hand, recent regarding potential therapeutic action tone by inhibition eCBs enzymes, modulation 2 (CB2r) activity on anxiolytic, antidepressive antipsychotic associated Further clinical research are needed, however, current evidence suggests that may become promising improve, least part, diagnosis treatment

Язык: Английский

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