Management of side effects during and post-treatment in breast cancer survivors

The Breast Journal, Год журнала: 2017, Номер 24(2), С. 167 - 175

Опубликована: Авг. 27, 2017

Cancer-related fatigue, insomnia, and cancer-related cognitive impairment are commonly experienced symptoms that share psychological physical manifestations. One or more of these will affect nearly all patients at some point during their course treatment survivorship. These side effects burdensome reduce patients' quality life well beyond cancer diagnosis associated care treatments. likely to have multiple etiologies make it difficult identify the most effective method manage them. In this review, we summarized information on incidence prevalence among breast survivors as recent research findings pharmaceutical, psychological, exercise interventions shown effectiveness in effects. Our review revealed current pharmaceutical tend ameliorate only temporarily without addressing underlying causes. Exercise behavioral consistently managing chronic possibly address an etiology. Future is needed investigate can be delivered directly clinic a large portion survivors.

Язык: Английский

---

ZnO-Based Nanoplatforms for Labeling and Treatment of Mouse Tumors without Detectable Toxic Side Effects

ACS Nano, Год журнала: 2016, Номер 10(4), С. 4294 - 4300

Опубликована: Март 28, 2016

ZnO quantum dots (QDs) were synthesized with polymer shells, coordinated Gd(3+) ions and adsorbed doxorubicin (DOX) together to form a new kind of multifunctional ZnO-Gd-DOX nanoplatform. Such pH sensitive nanoplatforms shown release DOX cancer cells in vitro mouse tumors vivo, reveal better specificity lower toxicity than free DOX, even therapeutic efficacy an FDA approved commercial DOX-loading drug DOX-Liposome Injection (DOXIL, NDA#050718). The exhibited strong red fluorescence, which benefited the fluorescent imaging on live mice. Due special structure nanoparticles, such possessed high longitudinal relaxivity r1 52.5 mM(-1) s(-1) at 0.55 T, was superior many other based nanoparticles. Thus, both fluorescence labeling magnetic resonance could be applied simultaneously tumor bearing mice along delivery. After 36 days treatment these mice, nanoparticles greatly inhibited growth without causing any appreciable abnormality major organs. most important merit that nanoplatform biodegraded completely showed no toxic side effects after H&E (hematoxylin eosin) staining slices ICP-AES (inductively coupled plasma atomic emission spectrometry) bioanalyses.

Язык: Английский

---

The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs

Immune Network, Год журнала: 2020, Номер 20(4)

Опубликована: Янв. 1, 2020

The development of refractory tumor cells limits therapeutic efficacy in cancer by activating mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival. Benzimidazole anthelmintics have broad-spectrum action to remove parasites both human veterinary medicine. In addition being antiparasitic agents, benzimidazole are known exert anticancer activities, such as the disruption microtubule polymerization, induction apoptosis, cell cycle (G2/M) arrest, anti-angiogenesis, blockage glucose transport. These antitumorigenic effects even extend resistant approved therapies when combination with conventional therapeutics, enhance hold promise adjuvants. Above all, these may offer a broad, safe spectrum treat cancer, demonstrated their long history use agents. present review summarizes central literature regarding anthelmintics, including albendazole, parbendazole, fenbendazole, mebendazole, oxibendazole, oxfendazole, ricobendazole, flubendazole lines, animal models, clinical trials. This provides valuable information on how improve quality life patients cancers increasing treatment options decreasing side from therapy.

Язык: Английский

---

Carbon dot/WS2 heterojunctions for NIR-II enhanced photothermal therapy of osteosarcoma and bone regeneration

Chemical Engineering Journal, Год журнала: 2019, Номер 383, С. 123102 - 123102

Опубликована: Окт. 8, 2019

Язык: Английский

---

Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(4), С. 1242 - 1242

Опубликована: Фев. 13, 2020

Among the severe side effects induced by cisplatin chemotherapy, muscle wasting is most relevant one. This effect a major cause for clinical decline of cancer patients, since it negative predictor treatment outcome and associated to increased mortality. However, despite its toxicity even at low doses, remains first-line therapy several types solid tumors. Thus, effective pharmacological treatments counteracting or minimizing cisplatin-induced are urgently needed. The dissection molecular pathways responsible dysfunction gives possibility identify novel promising therapeutic targets. In this context, use animal model cachexia very useful. Here, we report an update researches on mechanisms underlying potential options preserve mass function.

Язык: Английский

---

Engineering Magnetosomes for High-Performance Cancer Vaccination

ACS Central Science, Год журнала: 2019, Номер 5(5), С. 796 - 807

Опубликована: Апрель 3, 2019

A novel cancer vaccine is developed by using Fe3O4 magnetic nanoclusters (MNCs) as the core and cell membranes decorated with anti-CD205 cloak. Because of superparamagnetism magnetization MNCs, it first achieved for retention in lymph nodes a resonance imaging (MRI) guide, which opened time window antigen uptake dendritic cells (DCs). Meanwhile, camouflaged serve reservoir various antigens, enabling subsequent multiantigenic response. Additionally, direct more into CD8+ DCs, facilitating major histocompatibility complex (MHC) I cross-presentation. These unique advantages together lead to great proliferation T superior clonal diversity cytotoxic activity. As result, potent prophylactic therapeutic effects few abnormalities are observed on five different tumor models. Therefore, such cancer-derived magnetosome integration recent nanotechnologies successfully demonstrates its promise safe high-performance vaccination.

Язык: Английский

---

Living Microalgae‐Based Magnetic Microrobots for Calcium Overload and Photodynamic Synergetic Cancer Therapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Abstract The combination of Ca 2+ overload and reactive oxygen species (ROS) production for cancer therapy offers a superior solution to the lack specificity in traditional antitumor strategies. However, current therapeutic platforms this strategy are primarily based on non‐targeting nanomaterials, leading undesirable off‐target side effects. Additionally, resistance ROS apoptosis induced by hypoxic tumor microenvironment (TME) further limits efficiency. Herein, magnetic microrobot living Spirulina Platensis (SP), which is coated with double layer Fe 3 O 4 nanoparticles (NPs) CaCO NPs. microrobots can accumulate regions under attraction, produces high‐Ca environment acidic TME facilitates ultrasound (US) stimulation. Meanwhile, sufficient (O 2 ) photosynthesis helps alleviate hypoxia promotes situ chlorophyll‐mediated photodynamic (PDT), coordinate induce cell apoptosis. With these unique properties, SP‐based offer promising microrobotics‐based accumulation production, contributing precise effective way treatment.

Язык: Английский

---

Optimizing Dosing of Oncology Drugs

Clinical Pharmacology & Therapeutics, Год журнала: 2014, Номер 96(5), С. 572 - 579

Опубликована: Авг. 8, 2014

The purpose of this article is to acknowledge the challenges in optimizing dosing oncology drugs and propose potential approaches address these order optimize effectiveness, minimize toxicity, promote adherence patients. These could provide better opportunities understand sources variability drug exposure clinical outcomes during development premarketing evaluation investigational new drugs. Clinical Pharmacology & Therapeutics (2014); 96 5, 572–579. doi:10.1038/clpt.2014.153

Язык: Английский

---

Carbon dioxide laser treatment for vulvovaginal atrophy in women treated for breast cancer: Preliminary results of the feasibility EPIONE trial

Annales de Chirurgie Plastique Esthétique, Год журнала: 2020, Номер 65(4), С. e23 - e31

Опубликована: Июнь 5, 2020

---

A tumor-targeting fluorescent probe for ratiometric imaging of pH and improving PDT/PTT synergistic therapy

Sensors and Actuators B Chemical, Год журнала: 2023, Номер 393, С. 134287 - 134287

Опубликована: Июль 12, 2023

Язык: Английский

---