Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
187, P. 106610 - 106610
Published: Dec. 12, 2022
Gastric
cancer
(GC)
occurs
in
the
gastric
mucosa,
and
its
high
morbidity
mortality
make
it
an
international
health
crisis.
Therefore,
novel
drugs
are
needed
for
treatment.
The
use
of
natural
products
their
components
treatments
has
shown
promise.
this
study
aimed
to
evaluate
effect
8-paradol,
a
phenolic
compound
isolated
from
ginger
(Zingiber
officinale
Roscoe),
on
GC
determine
underlying
mechanisms
action.
In
study,
repeated
column
chromatography
was
conducted
EtOH
extract
isolate
gingerol
derivatives.
cytotoxicity
eight
compounds
underwent
(3-(4,5-dimethylthiazol-2-yl)−
2,5-diphenyltetrazolium
bromide)
tetrazolium
reduction
(MTT)
assay.
8-paradol
showed
most
potent
among
compounds.
mechanism
by
which
regulated
specific
proteins
AGS
cells
evaluated
proteomic
analysis.
To
validate
predicted
mechanisms,
thymus-deficient
nude
mice
bearing
xenografts
were
used
as
vitro
vivo
models
GC,
respectively.
results
that
promoted
PINK1/Parkin-associated
mitophagy,
mediating
cell
apoptosis.
Additionally,
inhibition
mitophagy
chloroquine
(CQ)
ameliorated
8-paradol-induced
mitochondrial
dysfunction
apoptosis,
supporting
causative
role
anticancer
effect.
Molecular
docking
revealed
molecular
interactions
between
mitophagy-/
apoptosis-related
at
atomic
level.
Our
provides
strong
evidence
could
act
potential
therapeutic
agent
suppress
progression
targeting
pathway.
The Breast Journal,
Journal Year:
2017,
Volume and Issue:
24(2), P. 167 - 175
Published: Aug. 27, 2017
Cancer-related
fatigue,
insomnia,
and
cancer-related
cognitive
impairment
are
commonly
experienced
symptoms
that
share
psychological
physical
manifestations.
One
or
more
of
these
will
affect
nearly
all
patients
at
some
point
during
their
course
treatment
survivorship.
These
side
effects
burdensome
reduce
patients'
quality
life
well
beyond
cancer
diagnosis
associated
care
treatments.
likely
to
have
multiple
etiologies
make
it
difficult
identify
the
most
effective
method
manage
them.
In
this
review,
we
summarized
information
on
incidence
prevalence
among
breast
survivors
as
recent
research
findings
pharmaceutical,
psychological,
exercise
interventions
shown
effectiveness
in
effects.
Our
review
revealed
current
pharmaceutical
tend
ameliorate
only
temporarily
without
addressing
underlying
causes.
Exercise
behavioral
consistently
managing
chronic
possibly
address
an
etiology.
Future
is
needed
investigate
can
be
delivered
directly
clinic
a
large
portion
survivors.
ACS Nano,
Journal Year:
2016,
Volume and Issue:
10(4), P. 4294 - 4300
Published: March 28, 2016
ZnO
quantum
dots
(QDs)
were
synthesized
with
polymer
shells,
coordinated
Gd(3+)
ions
and
adsorbed
doxorubicin
(DOX)
together
to
form
a
new
kind
of
multifunctional
ZnO-Gd-DOX
nanoplatform.
Such
pH
sensitive
nanoplatforms
shown
release
DOX
cancer
cells
in
vitro
mouse
tumors
vivo,
reveal
better
specificity
lower
toxicity
than
free
DOX,
even
therapeutic
efficacy
an
FDA
approved
commercial
DOX-loading
drug
DOX-Liposome
Injection
(DOXIL,
NDA#050718).
The
exhibited
strong
red
fluorescence,
which
benefited
the
fluorescent
imaging
on
live
mice.
Due
special
structure
nanoparticles,
such
possessed
high
longitudinal
relaxivity
r1
52.5
mM(-1)
s(-1)
at
0.55
T,
was
superior
many
other
based
nanoparticles.
Thus,
both
fluorescence
labeling
magnetic
resonance
could
be
applied
simultaneously
tumor
bearing
mice
along
delivery.
After
36
days
treatment
these
mice,
nanoparticles
greatly
inhibited
growth
without
causing
any
appreciable
abnormality
major
organs.
most
important
merit
that
nanoplatform
biodegraded
completely
showed
no
toxic
side
effects
after
H&E
(hematoxylin
eosin)
staining
slices
ICP-AES
(inductively
coupled
plasma
atomic
emission
spectrometry)
bioanalyses.
Immune Network,
Journal Year:
2020,
Volume and Issue:
20(4)
Published: Jan. 1, 2020
The
development
of
refractory
tumor
cells
limits
therapeutic
efficacy
in
cancer
by
activating
mechanisms
that
promote
cellular
proliferation,
migration,
invasion,
metastasis,
and
survival.
Benzimidazole
anthelmintics
have
broad-spectrum
action
to
remove
parasites
both
human
veterinary
medicine.
In
addition
being
antiparasitic
agents,
benzimidazole
are
known
exert
anticancer
activities,
such
as
the
disruption
microtubule
polymerization,
induction
apoptosis,
cell
cycle
(G2/M)
arrest,
anti-angiogenesis,
blockage
glucose
transport.
These
antitumorigenic
effects
even
extend
resistant
approved
therapies
when
combination
with
conventional
therapeutics,
enhance
hold
promise
adjuvants.
Above
all,
these
may
offer
a
broad,
safe
spectrum
treat
cancer,
demonstrated
their
long
history
use
agents.
present
review
summarizes
central
literature
regarding
anthelmintics,
including
albendazole,
parbendazole,
fenbendazole,
mebendazole,
oxibendazole,
oxfendazole,
ricobendazole,
flubendazole
lines,
animal
models,
clinical
trials.
This
provides
valuable
information
on
how
improve
quality
life
patients
cancers
increasing
treatment
options
decreasing
side
from
therapy.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(4), P. 1242 - 1242
Published: Feb. 13, 2020
Among
the
severe
side
effects
induced
by
cisplatin
chemotherapy,
muscle
wasting
is
most
relevant
one.
This
effect
a
major
cause
for
clinical
decline
of
cancer
patients,
since
it
negative
predictor
treatment
outcome
and
associated
to
increased
mortality.
However,
despite
its
toxicity
even
at
low
doses,
remains
first-line
therapy
several
types
solid
tumors.
Thus,
effective
pharmacological
treatments
counteracting
or
minimizing
cisplatin-induced
are
urgently
needed.
The
dissection
molecular
pathways
responsible
dysfunction
gives
possibility
identify
novel
promising
therapeutic
targets.
In
this
context,
use
animal
model
cachexia
very
useful.
Here,
we
report
an
update
researches
on
mechanisms
underlying
potential
options
preserve
mass
function.
ACS Central Science,
Journal Year:
2019,
Volume and Issue:
5(5), P. 796 - 807
Published: April 3, 2019
A
novel
cancer
vaccine
is
developed
by
using
Fe3O4
magnetic
nanoclusters
(MNCs)
as
the
core
and
cell
membranes
decorated
with
anti-CD205
cloak.
Because
of
superparamagnetism
magnetization
MNCs,
it
first
achieved
for
retention
in
lymph
nodes
a
resonance
imaging
(MRI)
guide,
which
opened
time
window
antigen
uptake
dendritic
cells
(DCs).
Meanwhile,
camouflaged
serve
reservoir
various
antigens,
enabling
subsequent
multiantigenic
response.
Additionally,
direct
more
into
CD8+
DCs,
facilitating
major
histocompatibility
complex
(MHC)
I
cross-presentation.
These
unique
advantages
together
lead
to
great
proliferation
T
superior
clonal
diversity
cytotoxic
activity.
As
result,
potent
prophylactic
therapeutic
effects
few
abnormalities
are
observed
on
five
different
tumor
models.
Therefore,
such
cancer-derived
magnetosome
integration
recent
nanotechnologies
successfully
demonstrates
its
promise
safe
high-performance
vaccination.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
Abstract
The
combination
of
Ca
2+
overload
and
reactive
oxygen
species
(ROS)
production
for
cancer
therapy
offers
a
superior
solution
to
the
lack
specificity
in
traditional
antitumor
strategies.
However,
current
therapeutic
platforms
this
strategy
are
primarily
based
on
non‐targeting
nanomaterials,
leading
undesirable
off‐target
side
effects.
Additionally,
resistance
ROS
apoptosis
induced
by
hypoxic
tumor
microenvironment
(TME)
further
limits
efficiency.
Herein,
magnetic
microrobot
living
Spirulina
Platensis
(SP),
which
is
coated
with
double
layer
Fe
3
O
4
nanoparticles
(NPs)
CaCO
NPs.
microrobots
can
accumulate
regions
under
attraction,
produces
high‐Ca
environment
acidic
TME
facilitates
ultrasound
(US)
stimulation.
Meanwhile,
sufficient
(O
2
)
photosynthesis
helps
alleviate
hypoxia
promotes
situ
chlorophyll‐mediated
photodynamic
(PDT),
coordinate
induce
cell
apoptosis.
With
these
unique
properties,
SP‐based
offer
promising
microrobotics‐based
accumulation
production,
contributing
precise
effective
way
treatment.
Clinical Pharmacology & Therapeutics,
Journal Year:
2014,
Volume and Issue:
96(5), P. 572 - 579
Published: Aug. 8, 2014
The
purpose
of
this
article
is
to
acknowledge
the
challenges
in
optimizing
dosing
oncology
drugs
and
propose
potential
approaches
address
these
order
optimize
effectiveness,
minimize
toxicity,
promote
adherence
patients.
These
could
provide
better
opportunities
understand
sources
variability
drug
exposure
clinical
outcomes
during
development
premarketing
evaluation
investigational
new
drugs.
Clinical
Pharmacology
&
Therapeutics
(2014);
96
5,
572–579.
doi:10.1038/clpt.2014.153
