ROS Function in Redox Signaling and Oxidative Stress

Current Biology, Год журнала: 2014, Номер 24(10), С. R453 - R462

Опубликована: Май 1, 2014

Язык: Английский

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Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Nature Reviews Molecular Cell Biology, Год журнала: 2020, Номер 21(7), С. 363 - 383

Опубликована: Март 30, 2020

Язык: Английский

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ROS Are Good

Trends in Plant Science, Год журнала: 2016, Номер 22(1), С. 11 - 19

Опубликована: Сен. 24, 2016

Reactive oxygen species (ROS) are thought to play a dual role in plant biology. They required for many important signaling reactions, but also toxic byproducts of aerobic metabolism. Recent studies revealed that ROS necessary the progression several basic biological processes including cellular proliferation and differentiation. Moreover, cell death-that was previously be outcome directly killing cells by oxidation, other words via oxidative stress-is now considered result triggering physiological or programmed pathway death. This Opinion focuses on possibility beneficial plants, supporting proliferation, function, viability, maintaining basal level is essential life.

Язык: Английский

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Fundamentals of cancer metabolism

Science Advances, Год журнала: 2016, Номер 2(5)

Опубликована: Май 6, 2016

Researchers provide a conceptual framework to understand current knowledge of the fundamentals cancer metabolism.

Язык: Английский

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Broadening horizons: the role of ferroptosis in cancer

Nature Reviews Clinical Oncology, Год журнала: 2021, Номер 18(5), С. 280 - 296

Опубликована: Янв. 29, 2021

Язык: Английский

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Reactive Oxygen Species (ROS)-Based Nanomedicine

Chemical Reviews, Год журнала: 2019, Номер 119(8), С. 4881 - 4985

Опубликована: Апрель 11, 2019

Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. The intrinsic biochemical properties ROS, which underlie the mechanisms necessary for growth, fitness, or aging organisms, have been driving researchers to take full advantage these active chemical contributing medical advances. Thanks remarkable advances nanotechnology, great varieties nanomaterials with unique ROS-regulating explored guide temporospatial dynamic behaviors ROS biological milieu, contributes emergence a new-generation therapeutic methodology, i.e., nanomaterial-guided vivo evolution therapy. interdependent relationship between and their corresponding chemistry, biology, nanotherapy leads us propose concept "ROS science", is believed be emerging scientific discipline that studies mechanisms, effects, nanotherapeutic applications ROS. In this review, state-of-art concerning recent progresses on ROS-based nanotherapies summarized detail, emphasis underlying material chemistry by are generated scavenged improved outcomes. Furthermore, key issues cross-disciplinary fields also discussed, aiming unlock innate powers optimized efficacies. We expect our demonstration evolving field will beneficial further development fundamental researches clinical applications.

Язык: Английский

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Oxidative Stress in Cancer

Cancer Cell, Год журнала: 2020, Номер 38(2), С. 167 - 197

Опубликована: Июль 9, 2020

Язык: Английский

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Cellular mechanisms and physiological consequences of redox-dependent signalling

Nature Reviews Molecular Cell Biology, Год журнала: 2014, Номер 15(6), С. 411 - 421

Опубликована: Май 23, 2014

Язык: Английский

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Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

Redox Biology, Год журнала: 2017, Номер 14, С. 450 - 464

Опубликована: Окт. 19, 2017

Oxidative stress is known to play an important role in the pathogenesis of a number diseases. In particular, it linked etiology Alzheimer's disease (AD), age-related neurodegenerative and most common cause dementia elderly. Histopathological hallmarks AD are intracellular neurofibrillary tangles extracellular formation senile plaques composed amyloid-beta peptide (Aβ) aggregated form along with metal-ions such as copper, iron or zinc. Redox active metal ions, for example can catalyze production Reactive Oxygen Species (ROS) when bound amyloid-β (Aβ). The ROS thus produced, particular hydroxyl radical which reactive one, may contribute oxidative damage on both Aβ itself surrounding molecule (proteins, lipids, …). This review highlights existing link between AD, consequences towards molecules terms damage. addition, implication ions their interaction redox properties leading discussed, vitro vivo oxidation peptide, at molecular level.

Язык: Английский

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Transcriptional Regulation by Nrf2

Antioxidants and Redox Signaling, Год журнала: 2017, Номер 29(17), С. 1727 - 1745

Опубликована: Окт. 20, 2017

Nuclear factor E2-related 2 (Nrf2) is a transcription that coordinates the basal and stress-inducible activation of vast array cytoprotective genes. Understanding regulation Nrf2 activity downstream pathways has major implications for human health. Recent Advances: regulates components glutathione thioredoxin antioxidant systems, as well enzymes involved in phase I II detoxification exogenous endogenous products, NADPH regeneration, heme metabolism. It therefore represents crucial regulator cellular defense mechanisms against xenobiotic oxidative stress. In addition to responses, other processes, such autophagy, intermediary metabolism, stem cell quiescence, unfolded protein response. Given wide range processes controls, its tightly regulated at multiple levels. Here, we review different modes current knowledge Nrf2-mediated transcriptional control.It now clear lies center complex regulatory network. A full comprehension program will require an integrated consideration all factors determining activity.Additional computational experimental studies are needed obtain more dynamic global view gene regulation. particular, comparing how Nrf2-dependent network changes from physiological pathological condition can provide insight into disease instruct new treatment strategies.

Язык: Английский

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