Obesity
increases
susceptibility
to
multiple
organ
disorders,
however,
underlying
mechanisms
remain
unclear.
The
subclinical
inflammation
assisted
by
obesity-induced
gut
permeability
may
underlie
obesity-associated
co-morbidities.
Despite
eminent
clinical
significance
of
the
obesity
led
barrier
abnormalities,
its
precise
molecular
regulation
remains
It
is
also
unknown
whether
deregulations,
similar
gut,
characterize
other
vital
organs
in
obese
individuals.
claudin
family
proteins
integral
tight
junction
(TJ),
apical
cell-cell
adhesion
and
a
key
regulator
epithelial
barrier.
Using
comprehensive
physiological
biochemical
analysis
intestinal
renal
tissues
from
high-fat
diet
fed
mice,
critical
for
maintaining
metabolic
homeostasis,
this
study
demonstrates
that
profound
TJ-restructuring
tissue-specific
switching
organs.
Protein
expression
cellular
distribution
were
examined.
In-silico
further
highlighted
potential
association
select
claudins,
modulated
obesity,
with
signaling
pathways
pathological
significance.
In
vitro
studies
using
Leptin
or
DCA-treatment
suggested
causal
changes
tissue
microenvironment
regulating
deregulations
manner.
Overall,
current
findings
advances
our
understanding
undertakings
associated
help
predispose
specific
diseases
identifies
novel
windows
preventive
and/or
therapeutic
interventions.
Acta Pharmaceutica Sinica B,
Год журнала:
2023,
Номер
13(6), С. 2403 - 2424
Опубликована: Янв. 13, 2023
The
occurrence
of
obesity
has
increased
across
the
whole
world.
Many
epidemiological
studies
have
indicated
that
strongly
contributes
to
development
cancer,
cardiovascular
diseases,
type
2
diabetes,
liver
diseases
and
other
disorders,
accounting
for
a
heavy
burden
on
public
health-care
systems
every
year.
Excess
energy
uptake
induces
adipocyte
hypertrophy,
hyperplasia
formation
visceral
fat
in
non-adipose
tissues
evoke
disease,
diseases.
Adipose
tissue
can
also
secrete
adipokines
inflammatory
cytokines
affect
local
microenvironment,
induce
insulin
resistance,
hyperglycemia,
activate
associated
signaling
pathways.
This
further
exacerbates
progression
obesity-associated
Although
some
progress
treatment
been
achieved
preclinical
clinical
studies,
pathogenesis
obesity-induced
are
complex
unclear.
We
still
need
understand
their
links
better
guide
In
this
review,
we
review
between
with
view
improve
future
management
its
co-morbidities.
Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Авг. 12, 2022
The
negative
effect
of
obesity
on
kidney
health
has
been
reported.
association
between
weight-adjusted-waist
index
(WWI,
a
newly
developed
adiposity
index)
and
albuminuria
not
reported
earlier.This
cross-sectional
study
was
conducted
among
adults
with
complete
data
about
WWI
urinary
albumin-to-creatinine
ratio
(ACR)
in
2005-2018
National
Health
Nutrition
Examination
Survey
(NHANES).
calculated
as
waist
circumference
(WC)
divided
by
the
square
root
weight.
Weighted
multivariable
logistic
regression
generalized
additive
model
were
employed
to
explore
independent
relationship
its
non-linearity.
A
two-piecewise
linear
used
calculate
threshold
effect.
Subgroup
analysis
interaction
tests
also
performed.A
total
36,921
participants
enrolled
prevalence
9.32%.
increased
higher
tertiles
(Tertile
1:
5.31%,
Tertile
2:
8.23%,
3:
15.65%).
positively
associated
likelihood
(OR
=
1.28,
95%
CI:
1.15-1.43),
this
remains
stable
subgroups
(all
P
for
trend
>
0.05).
Non-linear
positive
relationships
detected
females
breakpoint
10.93.
1.39,
1.20-1.61)
observed
right
breakpoint,
while
left
no
statistical
significance.
showed
stronger
correlation
1.28)
than
other
markers
including
body
mass
(BMI,
OR
1.02)
WC
1.01).Weight-adjusted-waist
levels
related
an
United
States
BMI
WC.
Our
findings
indicated
that
may
serve
simple
anthropometric
predict
albuminuria.
Circulation Research,
Год журнала:
2016,
Номер
118(6), С. 935 - 943
Опубликована: Фев. 17, 2016
Enhanced
activation
of
the
mineralocorticoid
receptors
(MRs)
in
cardiovascular
tissues
increases
oxidative
stress,
maladaptive
immune
responses,
and
inflammation
with
associated
functional
vascular
abnormalities.
We
previously
demonstrated
that
consumption
a
Western
diet
(WD)
for
16
weeks
results
aortic
stiffening,
these
abnormalities
were
prevented
by
systemic
MR
blockade
female
mice.
However,
cell-specific
role
endothelial
cell
(ECMR)
effects
has
not
been
explored.We
hypothesized
specific
deletion
ECMR
would
prevent
WD-induced
sodium
channel
activation,
reductions
bioavailable
nitric
oxide,
increased
remodeling,
stiffness
females.Four-week-old
knockout
wild-type
mice
fed
either
mouse
chow
or
WD
weeks.
feeding
resulted
dysfunction
as
determined
vivo
pulse
wave
velocity
ex
atomic
force
microscopy,
wire
pressure
myography.
The
was
enhanced
attenuated
oxide
synthase
proinflammatory
response
fibrosis.
Conversely,
deficiency
fibrosis
conjunction
stress
macrophage
polarization,
restoration
activation.Increased
signaling
plays
key
reduced
production,
lead
to
remodeling
AJP Regulatory Integrative and Comparative Physiology,
Год журнала:
2017,
Номер
314(3), С. R387 - R398
Опубликована: Ноя. 22, 2017
Obesity
is
an
emerging
pandemic
driven
by
consumption
of
a
diet
rich
in
fat
and
highly
refined
carbohydrates
(a
Western
diet)
sedentary
lifestyle
both
children
adults.
There
mounting
evidence
that
arterial
stiffness
obesity
independent
strong
predictor
cardiovascular
disease
(CVD),
cognitive
functional
decline,
chronic
kidney
disease.
Cardiovascular
precursor
to
atherosclerosis,
systolic
hypertension,
cardiac
diastolic
dysfunction,
impairment
coronary
cerebral
flow.
Moreover,
premenopausal
women
lose
the
CVD
protection
normally
afforded
them
setting
obesity,
insulin
resistance,
diabetes,
this
loss
inextricably
linked
increased
propensity
for
stiffness.
Stiffness
endothelial
vascular
smooth
muscle
cells,
extracellular
matrix
remodeling,
perivascular
adipose
tissue
inflammation,
immune
cell
dysfunction
contribute
development
obesity.
Enhanced
cortical
decreases
generation
nitric
oxide,
oxidative
stress
promotes
destruction
oxide.
Our
research
over
past
5
years
has
underscored
important
role
aldosterone
mineralocorticoid
receptor
activation
driving
stiffness,
especially
females
consuming
diet.
In
review
cellular
mechanisms
obesity-associated
are
highlighted.
The Korean Journal of Internal Medicine,
Год журнала:
2017,
Номер
32(3), С. 404 - 421
Опубликована: Апрель 18, 2017
The
global
burden
of
diabetes
mellitus
and
its
related
complications
are
currently
increasing.
Diabetes
affects
the
heart
through
various
mechanisms
including
microvascular
impairment,
metabolic
disturbance,
subcellular
component
abnormalities,
cardiac
autonomic
dysfunction,
a
maladaptive
immune
response.
Eventually,
can
cause
functional
structural
changes
in
myocardium
without
coronary
artery
disease,
disorder
known
as
diabetic
cardiomyopathy
(DCM).
There
many
diagnostic
tools
management
options
for
DCM,
although
it
is
difficult
to
detect
development
effectively
prevent
progression.
In
this
review,
we
summarize
current
research
regarding
pathophysiology
pathogenesis
DCM.
Moreover,
discuss
emerging
evaluation
methods
treatment
strategies
which
may
help
our
understanding
underlying
facilitate
identification
possible
new
therapeutic
targets.
Physiology,
Год журнала:
2017,
Номер
32(3), С. 197 - 209
Опубликована: Апрель 12, 2017
Obese
individuals
frequently
develop
hypertension,
which
is
for
an
important
part
attributable
to
renin-angiotensin-aldosterone
system
(RAAS)
overactivity.
This
review
summarizes
preclinical
and
clinical
evidence
on
the
involvement
of
dysfunctional
adipose
tissue
in
RAAS
activation
renal,
central,
vascular
mechanisms
linking
components
obesity-associated
hypertension.
Hypertension,
Год журнала:
2015,
Номер
66(1), С. 99 - 107
Опубликована: Май 27, 2015
Women
are
especially
predisposed
to
development
of
arterial
stiffening
secondary
obesity
because
consumption
excessive
calories.
Enhanced
activation
vascular
mineralocorticoid
receptors
impairs
insulin
signaling,
induces
oxidative
stress,
inflammation,
and
maladaptive
immune
responses.
We
tested
whether
a
subpressor
dose
receptor
antagonist,
spironolactone
(1
mg/kg
per
day)
prevents
aortic
femoral
artery
in
female
C57BL/6J
mice
fed
high-fat/high-sugar
western
diet
(WD)
for
4
months
(ie,
from
4-20
weeks
age).
Aortic
stiffness
were
assessed
using
ultrasound,
pressurized
vessel
preparations,
atomic
force
microscopy.
WD
induced
weight
gain
resistance
compared
with
control
diet-fed
these
abnormalities
unaffected
by
spironolactone.
Blood
pressures
heart
rates
normal
or
Spironolactone
prevented
WD-induced
aorta
artery,
as
well
endothelial
smooth
muscle
cells,
within
explants.
impaired
protein
kinase
B/endothelial
nitric
oxide
synthase
endothelium-dependent
endothelium-independent
vasodilation.
ameliorated
medial
thickening
fibrosis
the
associated
progrowth
extracellular
1/2
pathway.
Finally,
preservation
WD-fed
was
attenuated
systemic
inflammation
an
anti-inflammatory
shift
cell
marker
genes.
Low-dose
may
represent
novel
prevention
strategy
attenuate
growth
pathway
signaling
remodeling
prevent
WD.