Pflügers Archiv - European Journal of Physiology, Год журнала: 2018, Номер 470(2), С. 227 - 239
Опубликована: Янв. 4, 2018
Язык: Английский
Cell Metabolism, Год журнала: 2014, Номер 20(6), С. 991 - 1005
Опубликована: Дек. 1, 2014
Язык: Английский
Процитировано
825
Annual Review of Nutrition, Год журнала: 2017, Номер 37(1), С. 371 - 393
Опубликована: Июль 18, 2017
The objective of this review is to provide an overview intermittent fasting regimens, summarize the evidence on health benefits fasting, and discuss physiological mechanisms by which might lead improved outcomes. A MEDLINE search was performed using PubMed terms "intermittent fasting," "fasting," "time-restricted feeding," "food timing." Modified regimens appear promote weight loss may improve metabolic health. Several lines also support hypothesis that eating patterns reduce or eliminate nighttime prolong nightly intervals result in sustained improvements human Intermittent are hypothesized influence regulation via effects (a) circadian biology, (b) gut microbiome, (c) modifiable lifestyle behaviors, such as sleep. If proven be efficacious, these offer promising nonpharmacological approaches improving at population level, with multiple public benefits.
Язык: Английский
Процитировано
656
Proceedings of the National Academy of Sciences, Год журнала: 2016, Номер 113(10)
Опубликована: Фев. 8, 2016
Significance Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease, even after controlling traditional factors. workers frequently undergo circadian misalignment (i.e., between the endogenous system 24-h environmental/behavioral cycles). This has been proposed to explain, in part, why shift disease. However, impact of per se on blood pressure inflammatory markers poorly understood. We show—under highly controlled laboratory conditions—that short-term increases healthy adults. Our findings may help explain disease risk.
Язык: Английский
Процитировано
536
Nutrients, Год журнала: 2019, Номер 11(6), С. 1234 - 1234
Опубликована: Май 30, 2019
Time-restricted feeding (TRF) is a form of intermittent fasting that involves having longer daily period. Preliminary studies report TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how affects gene expression, circulating hormones, diurnal patterns risk factors Eleven overweight adults participated 4-day randomized crossover where they ate between 8 am 2 pm (early (eTRF)) (control schedule). Participants underwent continuous glucose monitoring, blood was drawn assess factors, expression whole cells. Relative control schedule, eTRF decreased mean 24-hour levels by 4 ± 1 mg/dl (p = 0.0003) glycemic excursions 12 3 0.001). In morning before breakfast, increased ketones, cholesterol, stress response aging SIRT1 autophagy LC3A (all p < 0.04), while evening, it tended increase brain-derived neurotropic factor (BNDF; 0.10) also MTOR 0.007), major nutrient-sensing protein regulates cell growth. altered cortisol several circadian clock genes 0.05). levels, alters lipid metabolism may have anti-aging effects
Язык: Английский
Процитировано
502
Proceedings of the National Academy of Sciences, Год журнала: 2015, Номер 112(17)
Опубликована: Апрель 13, 2015
Glucose tolerance is lower in the evening and at night than morning. However, relative contribution of circadian system vs. behavioral cycle (including sleep/wake fasting/feeding cycles) unclear. Furthermore, although shift work a diabetes risk factor, separate impact on glucose cycle, phase, disruption (i.e., misalignment between central pacemaker cycle) has not been systematically studied. Here we show--by using two 8-d laboratory protocols--in healthy adults that have distinct influences tolerance, both from cycle. First, postprandial was 17% higher tolerance) biological (8:00 PM) morning AM; i.e., phase effect), independent effect. Second, itself (12-h inversion) increased by 6%. Third, these variations appeared to be explained, least part, different mechanisms: during decreased pancreatic β-cell function (27% early-phase insulin) presumably insulin sensitivity (elevated despite 14% late-phase without change insulin. We explored possible contributing factors, including changes polysomnographic sleep 24-h hormonal profiles. demonstrate importantly contributes reduced observed compared with Separately, reduces providing mechanism help explain workers.
Язык: Английский
Процитировано
404
Nature Reviews Endocrinology, Год журнала: 2019, Номер 15(7), С. 393 - 405
Опубликована: Май 9, 2019
Язык: Английский
Процитировано
349
Trends in Food Science & Technology, Год журнала: 2016, Номер 59, С. 1 - 14
Опубликована: Ноя. 23, 2016
Язык: Английский
Процитировано
318
Ageing Research Reviews, Год журнала: 2016, Номер 39, С. 59 - 67
Опубликована: Дек. 23, 2016
Язык: Английский
Процитировано
263
Diabetologia, Год журнала: 2020, Номер 63(3), С. 462 - 472
Опубликована: Янв. 8, 2020
The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation which are vital for healthy bodily function. timing many physiological processes, including glucose metabolism, coordinated by system, and disruptions that desynchronise or misalign these can result in adverse health outcomes. In this review, we cover role its disruption metabolism individuals with type 2 diabetes mellitus. We begin defining then provide an overview regulation metabolism. next discuss impact on control diabetes. Given concurrent high prevalence disruption, understanding mechanisms underlying may aid improving glycaemic control.
Язык: Английский
Процитировано
250
Molecular Psychiatry, Год журнала: 2021, Номер 27(1), С. 502 - 513
Опубликована: Июль 21, 2021
Язык: Английский
Процитировано
228