Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges

Cell Metabolism, Journal Year: 2014, Volume and Issue: 20(6), P. 991 - 1005

Published: Dec. 1, 2014

Language: Английский

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Metabolic Effects of Intermittent Fasting

Annual Review of Nutrition, Journal Year: 2017, Volume and Issue: 37(1), P. 371 - 393

Published: July 18, 2017

The objective of this review is to provide an overview intermittent fasting regimens, summarize the evidence on health benefits fasting, and discuss physiological mechanisms by which might lead improved outcomes. A MEDLINE search was performed using PubMed terms "intermittent fasting," "fasting," "time-restricted feeding," "food timing." Modified regimens appear promote weight loss may improve metabolic health. Several lines also support hypothesis that eating patterns reduce or eliminate nighttime prolong nightly intervals result in sustained improvements human Intermittent are hypothesized influence regulation via effects (a) circadian biology, (b) gut microbiome, (c) modifiable lifestyle behaviors, such as sleep. If proven be efficacious, these offer promising nonpharmacological approaches improving at population level, with multiple public benefits.

Language: Английский

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Circadian misalignment increases cardiovascular disease risk factors in humans

Proceedings of the National Academy of Sciences, Journal Year: 2016, Volume and Issue: 113(10)

Published: Feb. 8, 2016

Significance Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease, even after controlling traditional factors. workers frequently undergo circadian misalignment (i.e., between the endogenous system 24-h environmental/behavioral cycles). This has been proposed to explain, in part, why shift disease. However, impact of per se on blood pressure inflammatory markers poorly understood. We show—under highly controlled laboratory conditions—that short-term increases healthy adults. Our findings may help explain disease risk.

Language: Английский

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Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

Nutrients, Journal Year: 2019, Volume and Issue: 11(6), P. 1234 - 1234

Published: May 30, 2019

Time-restricted feeding (TRF) is a form of intermittent fasting that involves having longer daily period. Preliminary studies report TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how affects gene expression, circulating hormones, diurnal patterns risk factors Eleven overweight adults participated 4-day randomized crossover where they ate between 8 am 2 pm (early (eTRF)) (control schedule). Participants underwent continuous glucose monitoring, blood was drawn assess factors, expression whole cells. Relative control schedule, eTRF decreased mean 24-hour levels by 4 ± 1 mg/dl (p = 0.0003) glycemic excursions 12 3 0.001). In morning before breakfast, increased ketones, cholesterol, stress response aging SIRT1 autophagy LC3A (all p < 0.04), while evening, it tended increase brain-derived neurotropic factor (BNDF; 0.10) also MTOR 0.007), major nutrient-sensing protein regulates cell growth. altered cortisol several circadian clock genes 0.05). levels, alters lipid metabolism may have anti-aging effects

Language: Английский

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Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans

Proceedings of the National Academy of Sciences, Journal Year: 2015, Volume and Issue: 112(17)

Published: April 13, 2015

Glucose tolerance is lower in the evening and at night than morning. However, relative contribution of circadian system vs. behavioral cycle (including sleep/wake fasting/feeding cycles) unclear. Furthermore, although shift work a diabetes risk factor, separate impact on glucose cycle, phase, disruption (i.e., misalignment between central pacemaker cycle) has not been systematically studied. Here we show--by using two 8-d laboratory protocols--in healthy adults that have distinct influences tolerance, both from cycle. First, postprandial was 17% higher tolerance) biological (8:00 PM) morning AM; i.e., phase effect), independent effect. Second, itself (12-h inversion) increased by 6%. Third, these variations appeared to be explained, least part, different mechanisms: during decreased pancreatic β-cell function (27% early-phase insulin) presumably insulin sensitivity (elevated despite 14% late-phase without change insulin. We explored possible contributing factors, including changes polysomnographic sleep 24-h hormonal profiles. demonstrate importantly contributes reduced observed compared with Separately, reduces providing mechanism help explain workers.

Language: Английский

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The circadian regulation of food intake

Nature Reviews Endocrinology, Journal Year: 2019, Volume and Issue: 15(7), P. 393 - 405

Published: May 9, 2019

Language: Английский

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Bioactive compounds and bioactivities of germinated edible seeds and sprouts: An updated review

Trends in Food Science & Technology, Journal Year: 2016, Volume and Issue: 59, P. 1 - 14

Published: Nov. 23, 2016

Language: Английский

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Circadian rhythms, time-restricted feeding, and healthy aging

Ageing Research Reviews, Journal Year: 2016, Volume and Issue: 39, P. 59 - 67

Published: Dec. 23, 2016

Language: Английский

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Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes

Diabetologia, Journal Year: 2020, Volume and Issue: 63(3), P. 462 - 472

Published: Jan. 8, 2020

The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation which are vital for healthy bodily function. timing many physiological processes, including glucose metabolism, coordinated by system, and disruptions that desynchronise or misalign these can result in adverse health outcomes. In this review, we cover role its disruption metabolism individuals with type 2 diabetes mellitus. We begin defining then provide an overview regulation metabolism. next discuss impact on control diabetes. Given concurrent high prevalence disruption, understanding mechanisms underlying may aid improving glycaemic control.

Language: Английский

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The neuroendocrinology of stress: the stress-related continuum of chronic disease development

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 27(1), P. 502 - 513

Published: July 21, 2021

Language: Английский

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