Molecular aspects of fructose metabolism and metabolic disease

Cell Metabolism, Год журнала: 2021, Номер 33(12), С. 2329 - 2354

Опубликована: Окт. 8, 2021

Язык: Английский

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An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury

Nature Medicine, Год журнала: 2017, Номер 24(1), С. 73 - 83

Опубликована: Дек. 11, 2017

Язык: Английский

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Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

FEBS Journal, Год журнала: 2022, Номер 290(6), С. 1420 - 1453

Опубликована: Янв. 8, 2022

Alzheimer’s disease (AD) is an age‐associated neurodegenerative disorder with multifactorial etiology, intersecting genetic and environmental risk factors, a lack of disease‐modifying therapeutics. While the abnormal accumulation lipids was described in very first report AD neuropathology, it not until recent decades that lipid dyshomeostasis became focus research. Clinically, lipidomic metabolomic studies have consistently shown alterations levels various classes emerging early stages brains. Mechanistically, discovery research revealed multifaceted interactions between metabolism key pathogenic mechanisms including amyloidogenesis, bioenergetic deficit, oxidative stress, neuroinflammation, myelin degeneration. In present review, converging evidence defining summarized, followed by discussions on which contributes to pathogenesis modifies risk. Furthermore, lipid‐targeting therapeutic strategies, modification their efficacy stage, ApoE status, metabolic vascular profiles, are reviewed.

Язык: Английский

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Gut microbiome lipid metabolism and its impact on host physiology

Cell Host & Microbe, Год журнала: 2023, Номер 31(2), С. 173 - 186

Опубликована: Фев. 1, 2023

Язык: Английский

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Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP

Nature Cell Biology, Год журнала: 2019, Номер 21(3), С. 338 - 347

Опубликована: Фев. 4, 2019

Язык: Английский

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