Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP DOI
Patrizia Romani,

Irene Brian,

Giulia Santinon

et al.

Nature Cell Biology, Journal Year: 2019, Volume and Issue: 21(3), P. 338 - 347

Published: Feb. 4, 2019

Language: Английский

Molecular aspects of fructose metabolism and metabolic disease DOI Creative Commons
Mark A. Herman, Morris J. Birnbaum

Cell Metabolism, Journal Year: 2021, Volume and Issue: 33(12), P. 2329 - 2354

Published: Oct. 8, 2021

Language: Английский

Citations

195
An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury DOI
Xiao‐Jing Zhang, Xu Cheng, Zhenzhen Yan

et al.

Nature Medicine, Journal Year: 2017, Volume and Issue: 24(1), P. 73 - 83

Published: Dec. 11, 2017

Language: Английский

Citations

194
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise DOI
Fei Yin

FEBS Journal, Journal Year: 2022, Volume and Issue: 290(6), P. 1420 - 1453

Published: Jan. 8, 2022

Alzheimer’s disease (AD) is an age‐associated neurodegenerative disorder with multifactorial etiology, intersecting genetic and environmental risk factors, a lack of disease‐modifying therapeutics. While the abnormal accumulation lipids was described in very first report AD neuropathology, it not until recent decades that lipid dyshomeostasis became focus research. Clinically, lipidomic metabolomic studies have consistently shown alterations levels various classes emerging early stages brains. Mechanistically, discovery research revealed multifaceted interactions between metabolism key pathogenic mechanisms including amyloidogenesis, bioenergetic deficit, oxidative stress, neuroinflammation, myelin degeneration. In present review, converging evidence defining summarized, followed by discussions on which contributes to pathogenesis modifies risk. Furthermore, lipid‐targeting therapeutic strategies, modification their efficacy stage, ApoE status, metabolic vascular profiles, are reviewed.

Language: Английский

Citations

190
Gut microbiome lipid metabolism and its impact on host physiology DOI Creative Commons
Eric Brown, Jon Clardy, Ramnik J. Xavier

et al.

Cell Host & Microbe, Journal Year: 2023, Volume and Issue: 31(2), P. 173 - 186

Published: Feb. 1, 2023

Language: Английский

Citations

182
Extracellular matrix mechanical cues regulate lipid metabolism through Lipin-1 and SREBP DOI
Patrizia Romani,

Irene Brian,

Giulia Santinon

et al.

Nature Cell Biology, Journal Year: 2019, Volume and Issue: 21(3), P. 338 - 347

Published: Feb. 4, 2019

Language: Английский

Citations

180