Free Fatty Acid Receptors in Health and Disease

Physiological Reviews, Год журнала: 2019, Номер 100(1), С. 171 - 210

Опубликована: Сен. 5, 2019

Fatty acids are metabolized and synthesized as energy substrates during biological responses. Long- medium-chain fatty derived mainly from dietary triglycerides, short-chain (SCFAs) produced by gut microbial fermentation of the otherwise indigestible fiber, constitute major sources free (FFAs) in metabolic network. Recently, increasing evidence indicates that FFAs serve not only but also natural ligands for a group orphan G protein-coupled receptors (GPCRs) termed acid (FFARs), essentially intertwining metabolism immunity multiple ways, such via inflammation regulation secretion peptide hormones. To date, several FFARs activated various chain lengths have been identified characterized. In particular, FFAR1 (GPR40) FFAR4 (GPR120) long-chain saturated unsaturated acids, while FFAR3 (GPR41) FFAR2 (GPR43) SCFAs, acetate, butyrate, propionate. this review, we discuss recent reports on key physiological functions FFAR-mediated signaling transduction pathways immune We attempt to reveal future research opportunities developing therapeutics disorders.

Язык: Английский

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Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Current Neurology and Neuroscience Reports, Год журнала: 2017, Номер 17(12)

Опубликована: Окт. 17, 2017

Язык: Английский

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Lactobacillus reuteri induces gut intraepithelial CD4 ⁺ CD8αα ⁺ T cells

Science, Год журнала: 2017, Номер 357(6353), С. 806 - 810

Опубликована: Авг. 4, 2017

Tolerogenic T cells need probiotics CD4 + CD8αα double-positive intraepithelial lymphocytes (DP IELs) are a recently discovered class of intestinal believed to take part in variety immune responses, including oral tolerance. These absent germ-free mice, but the mechanisms driving their development unclear. Cervantes-Barragan et al. found that particular species probiotic bacteria, Lactobacillus reuteri , induces DP IELs. This does not occur by stimulating system directly. Instead, L. generates specific derivative dietary tryptophan promotes differentiation IEL precursors. findings underscore delicate interplay between benign diet, and gut health. Science this issue p. 806

Язык: Английский

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Gut microbiota and Covid-19- possible link and implications

Virus Research, Год журнала: 2020, Номер 285, С. 198018 - 198018

Опубликована: Май 12, 2020

Язык: Английский

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Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

Cell Host & Microbe, Год журнала: 2020, Номер 27(4), С. 659 - 670.e5

Опубликована: Фев. 25, 2020

Язык: Английский

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