Pyroptosis: mechanisms and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)

Опубликована: Март 29, 2021

Abstract Currently, pyroptosis has received more and attention because of its association with innate immunity disease. The research scope expanded the discovery gasdermin family. A great deal evidence shows that can affect development tumors. relationship between tumors is diverse in different tissues genetic backgrounds. In this review, we provide basic knowledge pyroptosis, explain tumors, focus on significance tumor treatment. addition, further summarize possibility as a potential treatment strategy describe side effects radiotherapy chemotherapy caused by pyroptosis. brief, double-edged sword for rational use dual effect will help us explore formation ideas patients to develop new drugs based

Язык: Английский

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CD39 and CD73 in immunity and inflammation

Trends in Molecular Medicine, Год журнала: 2013, Номер 19(6), С. 355 - 367

Опубликована: Апрель 17, 2013

Язык: Английский

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Microglial cell origin and phenotypes in health and disease

Nature reviews. Immunology, Год журнала: 2011, Номер 11(11), С. 775 - 787

Опубликована: Окт. 25, 2011

Язык: Английский

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The P2X7 Receptor in Infection and Inflammation

Immunity, Год журнала: 2017, Номер 47(1), С. 15 - 31

Опубликована: Июль 1, 2017

Язык: Английский

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Cellular function and molecular structure of ecto-nucleotidases

Purinergic Signalling, Год журнала: 2012, Номер 8(3), С. 437 - 502

Опубликована: Май 3, 2012

Язык: Английский

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Nucleotide signalling during inflammation

Nature, Год журнала: 2014, Номер 509(7500), С. 310 - 317

Опубликована: Май 1, 2014

Язык: Английский

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Discerning the Chemistry in Individual Organelles with Small‐Molecule Fluorescent Probes

Angewandte Chemie International Edition, Год журнала: 2016, Номер 55(44), С. 13658 - 13699

Опубликована: Авг. 29, 2016

Abstract Principle has it that even the most advanced super‐resolution microscope would be futile in providing biological insight into subcellular matrices without well‐designed fluorescent tags/probes. Developments biology have increasingly been boosted by advances of chemistry, with one prominent example being small‐molecule probes not only allow cellular‐level imaging, but also imaging. A majority, if all, chemical/biological events take place inside cellular organelles, and researchers shifting their attention towards these substructures help fluorescence techniques. This Review summarizes existing target within a single organelle. More importantly, organelle‐anchoring strategies are described emphasized to inspire design new generations probes, before concluding future prospects on possible further development chemical biology.

Язык: Английский

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Inflammation and Neuroprotection in Traumatic Brain Injury

JAMA Neurology, Год журнала: 2015, Номер 72(3), С. 355 - 355

Опубликована: Янв. 19, 2015

Importance

Traumatic brain injury (TBI) is a significant public health concern that affects individuals in all demographics. With increasing interest the medical and communities, understanding inflammatory mechanisms drive pathologic consequent cognitive outcomes can inform future research clinical decisions for patients with TBI.

Objectives

To review known TBI to highlight trials neuroprotective therapeutic manipulations of

Evidence Review

We searched articles PubMed published between 1960 August 1, 2014, using following keywords:traumatic injury, sterile inflammation, astrocytes, microglia, monocytes, macrophages, neutrophils, T cells, reactive oxygen species, alarmins, danger-associated molecular patterns, purinergic receptors, neuroprotection,andclinical trials.Previous or studies involved manipulation discussed were considered inclusion. The final list selected was assembled based on novelty direct relevance primary focus this review.

Findings

diverse group injuries induced by secondary give rise cell death, neurologic dysfunction Pathogenesis driven complex, interacting include ion channel gap junction signaling, receptor excitotoxic neurotransmitter perturbations calcium homeostasis, damage-associated pattern molecules, among others. Central nervous system resident peripherally derived cells respond provide neuroprotection participate maladaptive reactions. exact contribution lesion dictated their anatomical positioning as well local cues which they are exposed.

Conclusions Relevance

development those promote repair exceedingly complex often superimposed. Because pathogenic diversify over time even differ type, it important therapeutics be developed administered these variables mind. Due its complexity, has proven particularly challenging treat; however, number promising approaches now under pre-clinical development, recent have yielded few successes. Given worldwide impact human population, imperative remains active area we continue develop improve outcome afflicted patients.

Язык: Английский

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Purinergic regulation of the immune system

Nature reviews. Immunology, Год журнала: 2016, Номер 16(3), С. 177 - 192

Опубликована: Фев. 29, 2016

Язык: Английский

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Immunity, inflammation and cancer: a leading role for adenosine

Nature reviews. Cancer, Год журнала: 2013, Номер 13(12), С. 842 - 857

Опубликована: Ноя. 14, 2013

Язык: Английский

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