Pyroptosis: mechanisms and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: March 29, 2021

Abstract Currently, pyroptosis has received more and attention because of its association with innate immunity disease. The research scope expanded the discovery gasdermin family. A great deal evidence shows that can affect development tumors. relationship between tumors is diverse in different tissues genetic backgrounds. In this review, we provide basic knowledge pyroptosis, explain tumors, focus on significance tumor treatment. addition, further summarize possibility as a potential treatment strategy describe side effects radiotherapy chemotherapy caused by pyroptosis. brief, double-edged sword for rational use dual effect will help us explore formation ideas patients to develop new drugs based

Language: Английский

---

CD39 and CD73 in immunity and inflammation

Trends in Molecular Medicine, Journal Year: 2013, Volume and Issue: 19(6), P. 355 - 367

Published: April 17, 2013

Language: Английский

---

Microglial cell origin and phenotypes in health and disease

Nature reviews. Immunology, Journal Year: 2011, Volume and Issue: 11(11), P. 775 - 787

Published: Oct. 25, 2011

Language: Английский

---

The P2X7 Receptor in Infection and Inflammation

Immunity, Journal Year: 2017, Volume and Issue: 47(1), P. 15 - 31

Published: July 1, 2017

Language: Английский

---

Cellular function and molecular structure of ecto-nucleotidases

Purinergic Signalling, Journal Year: 2012, Volume and Issue: 8(3), P. 437 - 502

Published: May 3, 2012

Language: Английский

---

Nucleotide signalling during inflammation

Nature, Journal Year: 2014, Volume and Issue: 509(7500), P. 310 - 317

Published: May 1, 2014

Language: Английский

---

Discerning the Chemistry in Individual Organelles with Small‐Molecule Fluorescent Probes

Angewandte Chemie International Edition, Journal Year: 2016, Volume and Issue: 55(44), P. 13658 - 13699

Published: Aug. 29, 2016

Abstract Principle has it that even the most advanced super‐resolution microscope would be futile in providing biological insight into subcellular matrices without well‐designed fluorescent tags/probes. Developments biology have increasingly been boosted by advances of chemistry, with one prominent example being small‐molecule probes not only allow cellular‐level imaging, but also imaging. A majority, if all, chemical/biological events take place inside cellular organelles, and researchers shifting their attention towards these substructures help fluorescence techniques. This Review summarizes existing target within a single organelle. More importantly, organelle‐anchoring strategies are described emphasized to inspire design new generations probes, before concluding future prospects on possible further development chemical biology.

Language: Английский

---

Inflammation and Neuroprotection in Traumatic Brain Injury

JAMA Neurology, Journal Year: 2015, Volume and Issue: 72(3), P. 355 - 355

Published: Jan. 19, 2015

Importance

Traumatic brain injury (TBI) is a significant public health concern that affects individuals in all demographics. With increasing interest the medical and communities, understanding inflammatory mechanisms drive pathologic consequent cognitive outcomes can inform future research clinical decisions for patients with TBI.

Objectives

To review known TBI to highlight trials neuroprotective therapeutic manipulations of

Evidence Review

We searched articles PubMed published between 1960 August 1, 2014, using following keywords:traumatic injury, sterile inflammation, astrocytes, microglia, monocytes, macrophages, neutrophils, T cells, reactive oxygen species, alarmins, danger-associated molecular patterns, purinergic receptors, neuroprotection,andclinical trials.Previous or studies involved manipulation discussed were considered inclusion. The final list selected was assembled based on novelty direct relevance primary focus this review.

Findings

diverse group injuries induced by secondary give rise cell death, neurologic dysfunction Pathogenesis driven complex, interacting include ion channel gap junction signaling, receptor excitotoxic neurotransmitter perturbations calcium homeostasis, damage-associated pattern molecules, among others. Central nervous system resident peripherally derived cells respond provide neuroprotection participate maladaptive reactions. exact contribution lesion dictated their anatomical positioning as well local cues which they are exposed.

Conclusions Relevance

development those promote repair exceedingly complex often superimposed. Because pathogenic diversify over time even differ type, it important therapeutics be developed administered these variables mind. Due its complexity, has proven particularly challenging treat; however, number promising approaches now under pre-clinical development, recent have yielded few successes. Given worldwide impact human population, imperative remains active area we continue develop improve outcome afflicted patients.

Language: Английский

---

Purinergic regulation of the immune system

Nature reviews. Immunology, Journal Year: 2016, Volume and Issue: 16(3), P. 177 - 192

Published: Feb. 29, 2016

Language: Английский

---

Immunity, inflammation and cancer: a leading role for adenosine

Nature reviews. Cancer, Journal Year: 2013, Volume and Issue: 13(12), P. 842 - 857

Published: Nov. 14, 2013

Language: Английский

---