Virus genomes and virus-host interactions in aquaculture animals DOI Creative Commons

Qi-Ya Zhang,

Jian‐Fang Gui

Science China Life Sciences, Год журнала: 2015, Номер 58(2), С. 156 - 169

Опубликована: Янв. 15, 2015

Over the last 30 years, aquaculture has become fastest growing form of agriculture production in world, but its development been hampered by a diverse range pathogenic viruses. During decade, large number viruses from aquatic animals have identified, and more than 100 viral genomes sequenced genetically characterized. These advances are leading to better understanding about antiviral mechanisms types interaction occurring between their hosts. Here, based on our research experience 20 we review wealth genetic genomic information studies viruses, including iridoviruses, herpesviruses, reoviruses, rhabdoviruses, outline some major virus-host interactions used aquaculture.

Язык: Английский

Antigen-Presenting Cells in the Skin DOI Open Access
Sakeen W. Kashem, Muzlifah Haniffa, Daniel H. Kaplan

и другие.

Annual Review of Immunology, Год журнала: 2017, Номер 35(1), С. 469 - 499

Опубликована: Фев. 22, 2017

Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes, and macrophages. They are highly dynamic, with capacity to enter from peripheral circulation, patrol within tissue, migrate through lymphatics draining lymph nodes. Skin APCs endowed antigen-sensing, -processing, -presenting machinery play key roles initiating, modulating, resolving cutaneous inflammation. a heterogeneous population functionally specialized subsets that developmentally imprinted modulated by local tissue microenvironmental inflammatory cues. This review explores recent advances have allowed for more accurate taxonomy of APC found both mouse human skin. It also examines functional specificity individual their collaboration other immune cell types together promote adaptive T regional responses during homeostasis, inflammation, disease.

Язык: Английский

Процитировано

311

Peripheral and Central Mechanisms of Itch DOI Creative Commons
Xintong Dong, Xinzhong Dong

Neuron, Год журнала: 2018, Номер 98(3), С. 482 - 494

Опубликована: Май 1, 2018

Язык: Английский

Процитировано

306

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements DOI Creative Commons
Praveen Kolimi, Sagar Narala, Dinesh Nyavanandi

и другие.

Cells, Год журнала: 2022, Номер 11(15), С. 2439 - 2439

Опубликована: Авг. 6, 2022

Wound healing is highly specialized dynamic multiple phase process for the repair of damaged/injured tissues through an intricate mechanism. Any failure in normal wound results abnormal scar formation, and chronic state which more susceptible to infections. Chronic wounds affect patients' quality life along with increased morbidity mortality are huge financial burden healthcare systems worldwide, thus requires biomedical intensive treatment its management. The clinical assessment management remains challenging despite development various therapeutic regimens owing painstakingly long-term requirement complex Various conventional approaches such as cell therapy, gene growth factor delivery, dressings, skin grafts etc., being utilized promoting different types wounds. However, all these abovementioned therapies not satisfactory types, therefore, there urgent demand competitive therapies. Therefore, a pertinent develop newer innovative modalities multipart Recent developments advanced care technology includes nanotherapeutics, stem cells bioengineered grafts, 3D bioprinting-based strategies improving outcomes focus on regeneration minimal side effects. main objective this review provide updated overview progress options over years using next generation approaches. Herein, we have discussed function anatomy, processes, followed by regeneration. Furthermore, emerging bioprinted skin, extracellular matrix-based approaches, platelet-rich plasma-based cold plasma therapy been their benefits shortcomings. Finally, challenges reviewed note future prospects.

Язык: Английский

Процитировано

278

The influence of skin microorganisms on cutaneous immunity DOI
Yasmine Belkaid,

Samira Tamoutounour

Nature reviews. Immunology, Год журнала: 2016, Номер 16(6), С. 353 - 366

Опубликована: Май 27, 2016

Язык: Английский

Процитировано

269

Topical and cutaneous delivery using nanosystems DOI
Michael S. Roberts, Yousuf Mohammed,

MN Pastore

и другие.

Journal of Controlled Release, Год журнала: 2016, Номер 247, С. 86 - 105

Опубликована: Дек. 23, 2016

Язык: Английский

Процитировано

243

Potential Role of the Microbiome in Acne: A Comprehensive Review DOI Open Access
Young Bok Lee,

Eun Jung Byun,

Hei Sung Kim

и другие.

Journal of Clinical Medicine, Год журнала: 2019, Номер 8(7), С. 987 - 987

Опубликована: Июль 7, 2019

Acne is a highly prevalent inflammatory skin condition involving sebaceous sties. Although it clearly develops from an interplay of multiple factors, the exact cause acne remains elusive. It increasingly believed that interaction between microbes and host immunity plays important role in this disease, with perturbed microbial composition activity found patients. Cutibacterium acnes (C. acnes; formerly called Propionibacterium acnes) commonly sebum-rich areas its over-proliferation has long been thought to contribute disease. However, information provided by advanced metagenomic sequencing indicated cutaneous microbiota patients acne-free individuals differ at virulent-specific lineage level. also close connections gastrointestinal tract, many argue gut could be involved pathogenic process acne. The emotions stress (e.g., depression anxiety), for instance, have hypothesized aggravate altering increasing intestinal permeability, potentially contributing inflammation. Over years, expanding body research highlighted presence gut–brain–skin axis connects microbes, oral probiotics, diet, currently area intense scrutiny, severity. This review concentrates on acne, immunobiology newly emerging microbiome-based therapies can applied treat

Язык: Английский

Процитировано

242

Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting DOI Creative Commons

Brian C. Palmer,

Lisa A. DeLouise

Molecules, Год журнала: 2016, Номер 21(12), С. 1719 - 1719

Опубликована: Дек. 15, 2016

Transdermal drug delivery systems have been around for decades, and current technologies (e.g., patches, ointments, creams) enhance the skin permeation of low molecular weight, lipophilic drugs that are efficacious at doses. The objective transdermal research is to discover ways penetration larger, hydrophilic macromolecules disease treatment vaccination. Nanocarriers made lipids, metals, or polymers successfully used increase vaccines, control release, target specific areas in vivo. While more needed identify safety nanocarriers, this technology has potential expand use routes administration a wide array therapeutics. Here, we review state nanoparticle with special emphasis on targeting diseases.

Язык: Английский

Процитировано

231

Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin DOI Creative Commons
Tiffany C. Scharschmidt, Kimberly S. Vasquez, Mariela Pauli

и другие.

Cell Host & Microbe, Год журнала: 2017, Номер 21(4), С. 467 - 477.e5

Опубликована: Март 23, 2017

Язык: Английский

Процитировано

222

The Crosstalk between Nrf2 and Inflammasomes DOI Open Access
Paulina Hennig,

Martha Garstkiewicz,

Serena Grossi

и другие.

International Journal of Molecular Sciences, Год журнала: 2018, Номер 19(2), С. 562 - 562

Опубликована: Фев. 13, 2018

The Nrf2 (nuclear factor E2-related or nuclear (erythroid-derived 2)-like 2) transcription is a key player in cytoprotection and activated stress conditions caused by reactive oxygen species (ROS) electrophiles. Inflammasomes represent central regulators of inflammation. Upon detection various factors, assembly the inflamasome protein complex results activation secretion proinflammatory cytokines. In addition, inflammasome causes pyroptosis, lytic form cell death, which supports There growing evidence crosstalk between pathways at different levels. For example, activating compounds inhibit inflammasomes consequently This review summarizes what known about predominantly antagonistic relationship both stress-activated pathways.

Язык: Английский

Процитировано

216

The innate immune system, toll-like receptors and dermal wound healing: A review DOI

Mark Portou,

Daryll Baker, David Abraham

и другие.

Vascular Pharmacology, Год журнала: 2015, Номер 71, С. 31 - 36

Опубликована: Апрель 11, 2015

Язык: Английский

Процитировано

212