Science China Life Sciences,
Год журнала:
2015,
Номер
58(2), С. 156 - 169
Опубликована: Янв. 15, 2015
Over
the
last
30
years,
aquaculture
has
become
fastest
growing
form
of
agriculture
production
in
world,
but
its
development
been
hampered
by
a
diverse
range
pathogenic
viruses.
During
decade,
large
number
viruses
from
aquatic
animals
have
identified,
and
more
than
100
viral
genomes
sequenced
genetically
characterized.
These
advances
are
leading
to
better
understanding
about
antiviral
mechanisms
types
interaction
occurring
between
their
hosts.
Here,
based
on
our
research
experience
20
we
review
wealth
genetic
genomic
information
studies
viruses,
including
iridoviruses,
herpesviruses,
reoviruses,
rhabdoviruses,
outline
some
major
virus-host
interactions
used
aquaculture.
Annual Review of Immunology,
Год журнала:
2017,
Номер
35(1), С. 469 - 499
Опубликована: Фев. 22, 2017
Professional
antigen-presenting
cells
(APCs)
in
the
skin
include
dendritic
cells,
monocytes,
and
macrophages.
They
are
highly
dynamic,
with
capacity
to
enter
from
peripheral
circulation,
patrol
within
tissue,
migrate
through
lymphatics
draining
lymph
nodes.
Skin
APCs
endowed
antigen-sensing,
-processing,
-presenting
machinery
play
key
roles
initiating,
modulating,
resolving
cutaneous
inflammation.
a
heterogeneous
population
functionally
specialized
subsets
that
developmentally
imprinted
modulated
by
local
tissue
microenvironmental
inflammatory
cues.
This
review
explores
recent
advances
have
allowed
for
more
accurate
taxonomy
of
APC
found
both
mouse
human
skin.
It
also
examines
functional
specificity
individual
their
collaboration
other
immune
cell
types
together
promote
adaptive
T
regional
responses
during
homeostasis,
inflammation,
disease.
Cells,
Год журнала:
2022,
Номер
11(15), С. 2439 - 2439
Опубликована: Авг. 6, 2022
Wound
healing
is
highly
specialized
dynamic
multiple
phase
process
for
the
repair
of
damaged/injured
tissues
through
an
intricate
mechanism.
Any
failure
in
normal
wound
results
abnormal
scar
formation,
and
chronic
state
which
more
susceptible
to
infections.
Chronic
wounds
affect
patients'
quality
life
along
with
increased
morbidity
mortality
are
huge
financial
burden
healthcare
systems
worldwide,
thus
requires
biomedical
intensive
treatment
its
management.
The
clinical
assessment
management
remains
challenging
despite
development
various
therapeutic
regimens
owing
painstakingly
long-term
requirement
complex
Various
conventional
approaches
such
as
cell
therapy,
gene
growth
factor
delivery,
dressings,
skin
grafts
etc.,
being
utilized
promoting
different
types
wounds.
However,
all
these
abovementioned
therapies
not
satisfactory
types,
therefore,
there
urgent
demand
competitive
therapies.
Therefore,
a
pertinent
develop
newer
innovative
modalities
multipart
Recent
developments
advanced
care
technology
includes
nanotherapeutics,
stem
cells
bioengineered
grafts,
3D
bioprinting-based
strategies
improving
outcomes
focus
on
regeneration
minimal
side
effects.
main
objective
this
review
provide
updated
overview
progress
options
over
years
using
next
generation
approaches.
Herein,
we
have
discussed
function
anatomy,
processes,
followed
by
regeneration.
Furthermore,
emerging
bioprinted
skin,
extracellular
matrix-based
approaches,
platelet-rich
plasma-based
cold
plasma
therapy
been
their
benefits
shortcomings.
Finally,
challenges
reviewed
note
future
prospects.
Journal of Clinical Medicine,
Год журнала:
2019,
Номер
8(7), С. 987 - 987
Опубликована: Июль 7, 2019
Acne
is
a
highly
prevalent
inflammatory
skin
condition
involving
sebaceous
sties.
Although
it
clearly
develops
from
an
interplay
of
multiple
factors,
the
exact
cause
acne
remains
elusive.
It
increasingly
believed
that
interaction
between
microbes
and
host
immunity
plays
important
role
in
this
disease,
with
perturbed
microbial
composition
activity
found
patients.
Cutibacterium
acnes
(C.
acnes;
formerly
called
Propionibacterium
acnes)
commonly
sebum-rich
areas
its
over-proliferation
has
long
been
thought
to
contribute
disease.
However,
information
provided
by
advanced
metagenomic
sequencing
indicated
cutaneous
microbiota
patients
acne-free
individuals
differ
at
virulent-specific
lineage
level.
also
close
connections
gastrointestinal
tract,
many
argue
gut
could
be
involved
pathogenic
process
acne.
The
emotions
stress
(e.g.,
depression
anxiety),
for
instance,
have
hypothesized
aggravate
altering
increasing
intestinal
permeability,
potentially
contributing
inflammation.
Over
years,
expanding
body
research
highlighted
presence
gut–brain–skin
axis
connects
microbes,
oral
probiotics,
diet,
currently
area
intense
scrutiny,
severity.
This
review
concentrates
on
acne,
immunobiology
newly
emerging
microbiome-based
therapies
can
applied
treat
Molecules,
Год журнала:
2016,
Номер
21(12), С. 1719 - 1719
Опубликована: Дек. 15, 2016
Transdermal
drug
delivery
systems
have
been
around
for
decades,
and
current
technologies
(e.g.,
patches,
ointments,
creams)
enhance
the
skin
permeation
of
low
molecular
weight,
lipophilic
drugs
that
are
efficacious
at
doses.
The
objective
transdermal
research
is
to
discover
ways
penetration
larger,
hydrophilic
macromolecules
disease
treatment
vaccination.
Nanocarriers
made
lipids,
metals,
or
polymers
successfully
used
increase
vaccines,
control
release,
target
specific
areas
in
vivo.
While
more
needed
identify
safety
nanocarriers,
this
technology
has
potential
expand
use
routes
administration
a
wide
array
therapeutics.
Here,
we
review
state
nanoparticle
with
special
emphasis
on
targeting
diseases.
International Journal of Molecular Sciences,
Год журнала:
2018,
Номер
19(2), С. 562 - 562
Опубликована: Фев. 13, 2018
The
Nrf2
(nuclear
factor
E2-related
or
nuclear
(erythroid-derived
2)-like
2)
transcription
is
a
key
player
in
cytoprotection
and
activated
stress
conditions
caused
by
reactive
oxygen
species
(ROS)
electrophiles.
Inflammasomes
represent
central
regulators
of
inflammation.
Upon
detection
various
factors,
assembly
the
inflamasome
protein
complex
results
activation
secretion
proinflammatory
cytokines.
In
addition,
inflammasome
causes
pyroptosis,
lytic
form
cell
death,
which
supports
There
growing
evidence
crosstalk
between
pathways
at
different
levels.
For
example,
activating
compounds
inhibit
inflammasomes
consequently
This
review
summarizes
what
known
about
predominantly
antagonistic
relationship
both
stress-activated
pathways.
