Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Nature Cell Biology, Год журнала: 2018, Номер 21(1), С. 9 - 17

Опубликована: Дек. 11, 2018

Язык: Английский

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The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

Cell, Год журнала: 2018, Номер 172(1-2), С. 275 - 288.e18

Опубликована: Янв. 1, 2018

Язык: Английский

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The role of cholesterol in membrane fusion

Chemistry and Physics of Lipids, Год журнала: 2016, Номер 199, С. 136 - 143

Опубликована: Май 11, 2016

Язык: Английский

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Fullerenes in biology and medicine

Journal of Materials Chemistry B, Год журнала: 2017, Номер 5(32), С. 6523 - 6535

Опубликована: Янв. 1, 2017

Fullerenes and related carbon based derivatives have shown a growing relevance in biology medicine, mainly due to the unique electronic structural properties that make them excellent candidates for multiple functionalization.

Язык: Английский

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Clinical targeting of HIV capsid protein with a long-acting small molecule

Nature, Год журнала: 2020, Номер 584(7822), С. 614 - 618

Опубликована: Июль 1, 2020

Язык: Английский

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The structure and flexibility of conical HIV-1 capsids determined within intact virions

Science, Год журнала: 2016, Номер 354(6318), С. 1434 - 1437

Опубликована: Дек. 15, 2016

HIV-1 contains a cone-shaped capsid encasing the viral genome. This is thought to follow fullerene geometry-a curved hexameric lattice of protein, CA, closed by incorporating 12 CA pentamers. Current models for core structure are based on crystallography and cross-linked pentameric electron microscopy tubular arrays, simulations. Here, we report subnanometer-resolution cryo-electron tomography structures within intact particles. Whereas hexamer compatible with studies, pentamer forms using different interfaces. Determining multiple revealed how flexes form variably shell. We show that assembles both aberrant perfect cones, supporting in which conical cores assemble de novo after maturation.

Язык: Английский

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Viral effects on the content and function of extracellular vesicles

Nature Reviews Microbiology, Год журнала: 2017, Номер 15(9), С. 559 - 572

Опубликована: Июнь 26, 2017

Язык: Английский

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T‐Cell‐Mimicking Nanoparticles Can Neutralize HIV Infectivity

Advanced Materials, Год журнала: 2018, Номер 30(45)

Опубликована: Сен. 25, 2018

Abstract To improve human immunodeficiency virus (HIV) treatment and prevention, therapeutic strategies that can provide effective broad‐spectrum neutralization against viral infection are highly desirable. Inspired by recent advances of cell‐membrane coating technology, herein, plasma membranes CD4 + T cells collected coated onto polymeric cores. The resulting T‐cell‐membrane‐coated nanoparticles (denoted as “TNPs”) inherit cell surface antigens critical for HIV binding, such receptor CCR5 or CXCR4 coreceptors. TNPs act decoys attack neutralize diverting the viruses away from their intended host targets. This decoy strategy, which simulates functions rather than directly suppressing replication machinery, has potential to overcome genetic diversity while not eliciting high selective pressure. In this study, it is demonstrated selectively bind with gp120, a key envelope glycoprotein HIV, inhibit gp120‐induced killing bystander cells. Furthermore, when added viruses, effectively peripheral mononuclear blood human‐monocyte‐derived macrophages in dose‐dependent manner. Overall, leveraging natural functions, show great new agent infection.

Язык: Английский

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Poly(lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation

Biomaterials, Год журнала: 2018, Номер 195, С. 23 - 37

Опубликована: Дек. 21, 2018

Язык: Английский

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Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses

Chemical Society Reviews, Год журнала: 2021, Номер 50(7), С. 4514 - 4540

Опубликована: Янв. 1, 2021

This review summarizes current advances in medicinal chemistry aimed at the discovery of antiviral compounds specifically targeted against drug-resistant strains.

Язык: Английский

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