The Life-Cycle of the HIV-1 Gag–RNA Complex DOI Creative Commons
Élodie Mailler, Serena Bernacchi, Roland Marquet

et al.

Viruses, Journal Year: 2016, Volume and Issue: 8(9), P. 248 - 248

Published: Sept. 10, 2016

Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to plasma membrane for assembly into infectious particles. This review highlights recent understanding selection genomic RNA (gRNA) by Pr55(Gag) precursor polyprotein, processes leading its incorporation

Language: Английский

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication DOI
Mathilde Mathieu, Lorena Martín‐Jaular, Grégory Lavieu

et al.

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 21(1), P. 9 - 17

Published: Dec. 11, 2018

Language: Английский

Citations

3070
The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer DOI Creative Commons

Elissa D. Pastuzyn,

Cameron E. Day,

Rachel B. Kearns

et al.

Cell, Journal Year: 2018, Volume and Issue: 172(1-2), P. 275 - 288.e18

Published: Jan. 1, 2018

Language: Английский

Citations

516
The role of cholesterol in membrane fusion DOI
Sung‐Tae Yang, Alex J.B. Kreutzberger, Jinwoo Lee

et al.

Chemistry and Physics of Lipids, Journal Year: 2016, Volume and Issue: 199, P. 136 - 143

Published: May 11, 2016

Language: Английский

Citations

356
Fullerenes in biology and medicine DOI
Edison Castro,

Andrea Hernandez Garcia,

Gerardo Zavala

et al.

Journal of Materials Chemistry B, Journal Year: 2017, Volume and Issue: 5(32), P. 6523 - 6535

Published: Jan. 1, 2017

Fullerenes and related carbon based derivatives have shown a growing relevance in biology medicine, mainly due to the unique electronic structural properties that make them excellent candidates for multiple functionalization.

Language: Английский

Citations

336
Clinical targeting of HIV capsid protein with a long-acting small molecule DOI

John O. Link,

Martin S. Rhee,

Winston C. Tse

et al.

Nature, Journal Year: 2020, Volume and Issue: 584(7822), P. 614 - 618

Published: July 1, 2020

Language: Английский

Citations

308
The structure and flexibility of conical HIV-1 capsids determined within intact virions DOI
Simone Matteï, Bärbel Glass, Wim J. H. Hagen

et al.

Science, Journal Year: 2016, Volume and Issue: 354(6318), P. 1434 - 1437

Published: Dec. 15, 2016

HIV-1 contains a cone-shaped capsid encasing the viral genome. This is thought to follow fullerene geometry-a curved hexameric lattice of protein, CA, closed by incorporating 12 CA pentamers. Current models for core structure are based on crystallography and cross-linked pentameric electron microscopy tubular arrays, simulations. Here, we report subnanometer-resolution cryo-electron tomography structures within intact particles. Whereas hexamer compatible with studies, pentamer forms using different interfaces. Determining multiple revealed how flexes form variably shell. We show that assembles both aberrant perfect cones, supporting in which conical cores assemble de novo after maturation.

Language: Английский

Citations

272
Viral effects on the content and function of extracellular vesicles DOI Open Access
Nancy Raab‐Traub, Dirk P. Dittmer

Nature Reviews Microbiology, Journal Year: 2017, Volume and Issue: 15(9), P. 559 - 572

Published: June 26, 2017

Language: Английский

Citations

231
T‐Cell‐Mimicking Nanoparticles Can Neutralize HIV Infectivity DOI
Xiaoli Wei, Gang Zhang,

Danni Ran

et al.

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(45)

Published: Sept. 25, 2018

Abstract To improve human immunodeficiency virus (HIV) treatment and prevention, therapeutic strategies that can provide effective broad‐spectrum neutralization against viral infection are highly desirable. Inspired by recent advances of cell‐membrane coating technology, herein, plasma membranes CD4 + T cells collected coated onto polymeric cores. The resulting T‐cell‐membrane‐coated nanoparticles (denoted as “TNPs”) inherit cell surface antigens critical for HIV binding, such receptor CCR5 or CXCR4 coreceptors. TNPs act decoys attack neutralize diverting the viruses away from their intended host targets. This decoy strategy, which simulates functions rather than directly suppressing replication machinery, has potential to overcome genetic diversity while not eliciting high selective pressure. In this study, it is demonstrated selectively bind with gp120, a key envelope glycoprotein HIV, inhibit gp120‐induced killing bystander cells. Furthermore, when added viruses, effectively peripheral mononuclear blood human‐monocyte‐derived macrophages in dose‐dependent manner. Overall, leveraging natural functions, show great new agent infection.

Language: Английский

Citations

177
Poly(lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation DOI Creative Commons
Anne-Line Coolen, Céline Lacroix, Perrine Mercier‐Gouy

et al.

Biomaterials, Journal Year: 2018, Volume and Issue: 195, P. 23 - 37

Published: Dec. 21, 2018

Language: Английский

Citations

165
Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses DOI
Yue Ma, Estrella Frutos-Beltrán, Dongwei Kang

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4514 - 4540

Published: Jan. 1, 2021

This review summarizes current advances in medicinal chemistry aimed at the discovery of antiviral compounds specifically targeted against drug-resistant strains.

Language: Английский

Citations

141