Npas4 Regulates a Transcriptional Program in CA3 Required for Contextual Memory Formation DOI

Kartik Ramamoorthi,

Robin Fropf,

Gabriel M. Belfort

и другие.

Science, Год журнала: 2011, Номер 334(6063), С. 1669 - 1675

Опубликована: Дек. 22, 2011

The rapid encoding of contextual memory requires the CA3 region hippocampus, but necessary genetic pathways remain unclear. We found that activity-dependent transcription factor Npas4 regulates a transcriptional program in is required for formation. was specifically expressed after learning. Global knockout or selective deletion both resulted impaired memory, and restoration sufficient to reverse deficit global mice. By recruiting RNA polymerase II promoters enhancers target genes, learning-specific includes many well-known activity-regulated which suggests master regulator gene programs central

Язык: Английский

Neurotrophin regulation of neural circuit development and function DOI
Hyungju Park,

Mu‐ming Poo

Nature reviews. Neuroscience, Год журнала: 2012, Номер 14(1), С. 7 - 23

Опубликована: Дек. 20, 2012

Язык: Английский

Процитировано

1785

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants DOI
Ronald S. Duman,

George K. Aghajanian,

Gerard Sanacora

и другие.

Nature Medicine, Год журнала: 2016, Номер 22(3), С. 238 - 249

Опубликована: Март 1, 2016

Язык: Английский

Процитировано

1371

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy DOI
Mark J. Millan,

Y. Agid,

Martin Brüne

и другие.

Nature Reviews Drug Discovery, Год журнала: 2012, Номер 11(2), С. 141 - 168

Опубликована: Фев. 1, 2012

Язык: Английский

Процитировано

1162

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity DOI Creative Commons
Przemysław Kowiański, Grażyna Lietzau, Ewelina Czuba

и другие.

Cellular and Molecular Neurobiology, Год журнала: 2017, Номер 38(3), С. 579 - 593

Опубликована: Июнь 16, 2017

Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in mammalian brain. Among its prominent functions, can mention control neuronal glial development, neuroprotection, modulation both short- long-lasting synaptic interactions, which are critical for cognition memory. A wide spectrum processes controlled by BDNF, sometimes contradictory effects action be explained based on specific pattern synthesis, comprising several intermediate biologically active isoforms that bind to different types receptor, triggering signaling pathways. The functions BDNF must discussed close relation stage brain cellular components nervous tissue, as well molecular mechanisms signal transduction activated under physiological pathological conditions. In this review, we briefly summarize current state knowledge regarding impact regulation neurophysiological processes. importance future studies aimed at disclosing activation pathways, neuro- gliogenesis, plasticity highlighted.

Язык: Английский

Процитировано

1112

The molecular basis of retinal ganglion cell death in glaucoma DOI
Mohammadali Almasieh, Ariel M. Wilson,

Barbara Morquette

и другие.

Progress in Retinal and Eye Research, Год журнала: 2011, Номер 31(2), С. 152 - 181

Опубликована: Дек. 9, 2011

Язык: Английский

Процитировано

884

Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer DOI Open Access
Luca Colucci-D’Amato, Luisa Speranza, Floriana Volpicelli

и другие.

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(20), С. 7777 - 7777

Опубликована: Окт. 21, 2020

Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively studied neurotrophins in mammalian brain. BDNF signals through tropomycin receptor kinase B (TrkB) low affinity p75 neurotrophin (p75NTR). plays an important role proper growth, development, plasticity glutamatergic GABAergic synapses modulation neuronal differentiation, it influences serotonergic dopaminergic neurotransmission. acts as paracrine autocrine factor, on both pre-synaptic post-synaptic target sites. It crucial transformation synaptic activity into long-term memories. considered instructive mediator functional structural central nervous system (CNS), influencing dendritic spines and, at least hippocampus, adult neurogenesis. Changes rate neurogenesis spine density can influence several forms learning memory contribute to depression-like behaviors. The possible roles highlighted this review focus effect antidepressant therapies BDNF-mediated plasticity. Moreover, we will data that illustrate a potent protective able confer protection against neurodegeneration, particular Alzheimer’s disease. Finally, give evidence how involvement pathogenesis brain glioblastoma has emerged, thus opening new avenues for treatment deadly cancer.

Язык: Английский

Процитировано

676

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents DOI Open Access
Ronald S. Duman,

Bhavya Voleti

Trends in Neurosciences, Год журнала: 2012, Номер 35(1), С. 47 - 56

Опубликована: Янв. 1, 2012

Язык: Английский

Процитировано

671

Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation DOI Creative Commons
Bruno Lima Giacobbo, Janine Doorduin, Hans Klein

и другие.

Molecular Neurobiology, Год журнала: 2018, Номер 56(5), С. 3295 - 3312

Опубликована: Авг. 17, 2018

Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in healthy and diseased brain. As a result, there large body evidence that associates BDNF with neuronal maintenance, survival, plasticity, neurotransmitter regulation. Patients psychiatric neurodegenerative disorders often have reduced concentrations their blood A current hypothesis suggests these abnormal levels might be due to chronic inflammatory state brain certain disorders, as neuroinflammation known affect several BDNF-related signaling pathways. Activation glia cells can induce an increase pro- antiinflammatory cytokines reactive oxygen species, which lead modulation function neurotoxicity observed pathologies. Understanding how involved brain, especially disease onset progression, crucial for development new strategies treatment. Despite increasing involvement scarce addresses interaction between neurotrophin diseases. This review focuses on effect acute inflammation common aims shed some light possible biological mechanisms may influence this effect. In addition, will address behavior pharmacological interventions disorders.

Язык: Английский

Процитировано

611

BDNF-induced local protein synthesis and synaptic plasticity DOI
Graciano Leal,

Diogo Comprido,

Carlos B. Duarte

и другие.

Neuropharmacology, Год журнала: 2013, Номер 76, С. 639 - 656

Опубликована: Апрель 17, 2013

Язык: Английский

Процитировано

607

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation DOI Creative Commons
Miquel Bosch, Jorge Castro, Takeo Saneyoshi

и другие.

Neuron, Год журнала: 2014, Номер 82(2), С. 444 - 459

Опубликована: Апрель 1, 2014

Язык: Английский

Процитировано

587