Science,
Год журнала:
2011,
Номер
334(6063), С. 1669 - 1675
Опубликована: Дек. 22, 2011
The
rapid
encoding
of
contextual
memory
requires
the
CA3
region
hippocampus,
but
necessary
genetic
pathways
remain
unclear.
We
found
that
activity-dependent
transcription
factor
Npas4
regulates
a
transcriptional
program
in
is
required
for
formation.
was
specifically
expressed
after
learning.
Global
knockout
or
selective
deletion
both
resulted
impaired
memory,
and
restoration
sufficient
to
reverse
deficit
global
mice.
By
recruiting
RNA
polymerase
II
promoters
enhancers
target
genes,
learning-specific
includes
many
well-known
activity-regulated
which
suggests
master
regulator
gene
programs
central
Cellular and Molecular Neurobiology,
Год журнала:
2017,
Номер
38(3), С. 579 - 593
Опубликована: Июнь 16, 2017
Brain-derived
neurotrophic
factor
(BDNF)
is
one
of
the
most
widely
distributed
and
extensively
studied
neurotrophins
in
mammalian
brain.
Among
its
prominent
functions,
can
mention
control
neuronal
glial
development,
neuroprotection,
modulation
both
short-
long-lasting
synaptic
interactions,
which
are
critical
for
cognition
memory.
A
wide
spectrum
processes
controlled
by
BDNF,
sometimes
contradictory
effects
action
be
explained
based
on
specific
pattern
synthesis,
comprising
several
intermediate
biologically
active
isoforms
that
bind
to
different
types
receptor,
triggering
signaling
pathways.
The
functions
BDNF
must
discussed
close
relation
stage
brain
cellular
components
nervous
tissue,
as
well
molecular
mechanisms
signal
transduction
activated
under
physiological
pathological
conditions.
In
this
review,
we
briefly
summarize
current
state
knowledge
regarding
impact
regulation
neurophysiological
processes.
importance
future
studies
aimed
at
disclosing
activation
pathways,
neuro-
gliogenesis,
plasticity
highlighted.
International Journal of Molecular Sciences,
Год журнала:
2020,
Номер
21(20), С. 7777 - 7777
Опубликована: Окт. 21, 2020
Brain-derived
neurotrophic
factor
(BDNF)
is
one
of
the
most
distributed
and
extensively
studied
neurotrophins
in
mammalian
brain.
BDNF
signals
through
tropomycin
receptor
kinase
B
(TrkB)
low
affinity
p75
neurotrophin
(p75NTR).
plays
an
important
role
proper
growth,
development,
plasticity
glutamatergic
GABAergic
synapses
modulation
neuronal
differentiation,
it
influences
serotonergic
dopaminergic
neurotransmission.
acts
as
paracrine
autocrine
factor,
on
both
pre-synaptic
post-synaptic
target
sites.
It
crucial
transformation
synaptic
activity
into
long-term
memories.
considered
instructive
mediator
functional
structural
central
nervous
system
(CNS),
influencing
dendritic
spines
and,
at
least
hippocampus,
adult
neurogenesis.
Changes
rate
neurogenesis
spine
density
can
influence
several
forms
learning
memory
contribute
to
depression-like
behaviors.
The
possible
roles
highlighted
this
review
focus
effect
antidepressant
therapies
BDNF-mediated
plasticity.
Moreover,
we
will
data
that
illustrate
a
potent
protective
able
confer
protection
against
neurodegeneration,
particular
Alzheimer’s
disease.
Finally,
give
evidence
how
involvement
pathogenesis
brain
glioblastoma
has
emerged,
thus
opening
new
avenues
for
treatment
deadly
cancer.
Molecular Neurobiology,
Год журнала:
2018,
Номер
56(5), С. 3295 - 3312
Опубликована: Авг. 17, 2018
Brain-derived
neurotrophic
factor
(BDNF)
is
one
of
the
most
studied
neurotrophins
in
healthy
and
diseased
brain.
As
a
result,
there
large
body
evidence
that
associates
BDNF
with
neuronal
maintenance,
survival,
plasticity,
neurotransmitter
regulation.
Patients
psychiatric
neurodegenerative
disorders
often
have
reduced
concentrations
their
blood
A
current
hypothesis
suggests
these
abnormal
levels
might
be
due
to
chronic
inflammatory
state
brain
certain
disorders,
as
neuroinflammation
known
affect
several
BDNF-related
signaling
pathways.
Activation
glia
cells
can
induce
an
increase
pro-
antiinflammatory
cytokines
reactive
oxygen
species,
which
lead
modulation
function
neurotoxicity
observed
pathologies.
Understanding
how
involved
brain,
especially
disease
onset
progression,
crucial
for
development
new
strategies
treatment.
Despite
increasing
involvement
scarce
addresses
interaction
between
neurotrophin
diseases.
This
review
focuses
on
effect
acute
inflammation
common
aims
shed
some
light
possible
biological
mechanisms
may
influence
this
effect.
In
addition,
will
address
behavior
pharmacological
interventions
disorders.
