Frontiers in Psychology, Год журнала: 2015, Номер 6
Опубликована: Ноя. 26, 2015
Social cognition is a complex process that requires the integration of wide variety behaviors, including salience, reward-seeking, motivation, knowledge self and others, flexibly adjusting behavior in social groups. Not surprisingly, represents sensitive domain commonly disrupted pathology psychiatric disorders Autism Spectrum Disorder (ASD) Schizophrenia (SCZ). Here, we discuss convergent research from animal models to human disease implicates prefrontal cortex (PFC) as key regulator cognition, suggesting disruptions microcircuitry play an essential role pathophysiology with shared deficits. We take translational perspective review three behaviors are normal processing rodents humans, recognition, dominance hierarchy. A circuitry may underlie these behaviors. deficits neurodevelopmental like ASD SCZ have been linked altered balance excitation inhibition (E/I ratio) within generally, PFC specifically. clear picture mechanisms by which E/I ratio might lead across not well understood. Future studies should explore how developmental trajectory could subsequent
Язык: Английский