Review: Neuroinflammatory pathways as treatment targets and biomarker candidates in epilepsy: emerging evidence from preclinical and clinical studies DOI Open Access
Erwin A. van Vliet, Eleonora Aronica, Annamaria Vezzani

и другие.

Neuropathology and Applied Neurobiology, Год журнала: 2017, Номер 44(1), С. 91 - 111

Опубликована: Окт. 4, 2017

Accumulating evidence indicates an important pathophysiological role of brain inflammation in epilepsy. In this review, we will provide update specific inflammatory pathways that have been proposed to be crucial the underlying molecular mechanisms epilepsy, including interleukin-1 receptor/toll-like receptor signalling, cyclooxygenase-2, tumour necrosis factor-alpha, complement signalling and chemokines. Furthermore, by drawing on from preclinical clinical studies discuss potential these targets for novel therapeutic interventions control drug-resistant seizures or disease-modifying effects. Finally, assess use as biomarkers development epilepsy measure effectiveness interventions.

Язык: Английский

Pain regulation by non-neuronal cells and inflammation DOI Open Access
Ru‐Rong Ji, Alexander Chamessian,

Yu‐Qiu Zhang

и другие.

Science, Год журнала: 2016, Номер 354(6312), С. 572 - 577

Опубликована: Ноя. 3, 2016

Acute pain is protective and a cardinal feature of inflammation. Chronic after arthritis, nerve injury, cancer, chemotherapy associated with chronic neuroinflammation, local inflammation in the peripheral or central nervous system. Accumulating evidence suggests that non-neuronal cells such as immune cells, glial keratinocytes, cancer stem play active roles pathogenesis resolution pain. We review how interact nociceptive neurons by secreting neuroactive signaling molecules modulate Recent studies also suggest bacterial infections regulate through direct actions on sensory neurons, specific receptors are present nociceptors to detect danger signals from infections. discuss new therapeutic strategies control neuroinflammation for prevention treatment

Язык: Английский

Процитировано

1093

The Sleep-Immune Crosstalk in Health and Disease DOI Creative Commons
Luciana Besedovsky, Tanja Lange, Monika Haack

и другие.

Physiological Reviews, Год журнала: 2019, Номер 99(3), С. 1325 - 1380

Опубликована: Март 28, 2019

Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, sleep in turn affects the innate adaptive arm of our body’s defense system. Stimulation immune by microbial challenges triggers an inflammatory response, which, depending on its magnitude time course, can induce increase duration intensity, but also a disruption sleep. Enhancement during infection is assumed to feedback promote host defense. Indeed, various parameters, associated with reduced risk, improve outcome vaccination responses. The induction hormonal constellation that supports functions one likely mechanism underlying immune-supporting effects In absence infectious challenge, appears homeostasis through several mediators, such as cytokines. This notion supported findings prolonged deficiency (e.g., short duration, disturbance) lead chronic, systemic low-grade inflammation diseases have component, like diabetes, atherosclerosis, neurodegeneration. Here, we review available data this regulatory sleep-immune crosstalk, point out methodological challenges, suggest questions open for future research.

Язык: Английский

Процитировано

1089

Neuroinflammation and Central Sensitization in Chronic and Widespread Pain DOI
Ru‐Rong Ji, Andrea G. Nackley, Yul Huh

и другие.

Anesthesiology, Год журнала: 2018, Номер 129(2), С. 343 - 366

Опубликована: Фев. 16, 2018

Abstract Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness pathways after painful insults. Accumulating evidence suggests that sensitization also driven neuroinflammation the peripheral nervous system. A characteristic feature activation glial cells, such as microglia astrocytes, spinal cord brain, leading to release proinflammatory cytokines chemokines. Recent studies suggest chemokines are powerful neuromodulators play sufficient role inducing hyperalgesia allodynia system administration. Sustained increase promotes chronic widespread affects multiple body sites. Thus, drives via sensitization. We discuss sex-dependent glial/immune signaling new therapeutic approaches control for resolution pain.

Язык: Английский

Процитировано

1085

Astrocyte barriers to neurotoxic inflammation DOI
Michael V. Sofroniew

Nature reviews. Neuroscience, Год журнала: 2015, Номер 16(5), С. 249 - 263

Опубликована: Апрель 20, 2015

Язык: Английский

Процитировано

1040

Emerging targets in neuroinflammation-driven chronic pain DOI
Ru‐Rong Ji, Zhen‐Zhong Xu, Yong‐Jing Gao

и другие.

Nature Reviews Drug Discovery, Год журнала: 2014, Номер 13(7), С. 533 - 548

Опубликована: Июнь 20, 2014

Язык: Английский

Процитировано

931

Epilepsy DOI
Orrin Devinsky, Annamaria Vezzani, Terence J. O’Brien

и другие.

Nature Reviews Disease Primers, Год журнала: 2018, Номер 4(1)

Опубликована: Май 3, 2018

Язык: Английский

Процитировано

729

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy DOI
Annamaria Vezzani, Silvia Balosso, Teresa Ravizza

и другие.

Nature Reviews Neurology, Год журнала: 2019, Номер 15(8), С. 459 - 472

Опубликована: Июль 1, 2019

Язык: Английский

Процитировано

666

Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression DOI
Ives Cavalcante Passos,

Mirela Paiva Vasconcelos-Moreno,

Leonardo Gazzi Costa

и другие.

The Lancet Psychiatry, Год журнала: 2015, Номер 2(11), С. 1002 - 1012

Опубликована: Окт. 30, 2015

Язык: Английский

Процитировано

638

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders DOI
Gislaine Z. Réus, Gabriel R. Fries, Laura Stertz

и другие.

Neuroscience, Год журнала: 2015, Номер 300, С. 141 - 154

Опубликована: Май 14, 2015

Язык: Английский

Процитировано

533

Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation DOI Creative Commons
Dora Brites, Adelaide Fernandes

Frontiers in Cellular Neuroscience, Год журнала: 2015, Номер 9

Опубликована: Дек. 17, 2015

Patients with chronic inflammation are often associated the emergence of depression symptoms, while diagnosed depressed patients show increased levels circulating cytokines. Further studies revealed activation brain immune cell microglia in a greater magnitude individuals that committed suicide, indicating crucial role for neuroinflammation pathogenesis. Rapid advances understanding microglial and astrocytic neurobiology were obtained past fifteen to twenty years. Indeed, recent data reveal play an important managing neuronal death, neurogenesis, synaptic interactions, besides their involvement immune-response generating The communication between neurons is essential synchronize these diverse functions activity. Evidence accumulating secreted extracellular vesicles (EVs), comprising ectosomes exosomes size ranging from 0.1 1 μm, key players intercellular signaling. These EVs may carry specific proteins, mRNAs microRNAs (miRNAs). Transfer was shown be mediated by oligodendrocytes, astrocytes either supportive neurons, or instead disseminate disease. Interestingly, several reports have identified changes miRNAs patients, which target not only pathways plasticity, learning memory but also production neurotrophic factors modulation. In this article, we discuss depression, namely dynamic alterations status response stimulation, how phenotypes etiological neurodegeneneration, particular depressive-like behavior. We will overview miRNAs, exosomes, regulating critical they contribute other disorders including amyotrophic lateral sclerosis, Alzheimer's disease Parkinson disease, share neuroinflammatory-associated processes. Specific reference made as potential biomarkers monitoring approaches, focusing on potentialities drug delivery vehicles putative therapeutic strategies using autologous exosome-based systems treat neurodegenerative psychiatric disorders.

Язык: Английский

Процитировано

516