Pain regulation by non-neuronal cells and inflammation

Science, Journal Year: 2016, Volume and Issue: 354(6312), P. 572 - 577

Published: Nov. 3, 2016

Acute pain is protective and a cardinal feature of inflammation. Chronic after arthritis, nerve injury, cancer, chemotherapy associated with chronic neuroinflammation, local inflammation in the peripheral or central nervous system. Accumulating evidence suggests that non-neuronal cells such as immune cells, glial keratinocytes, cancer stem play active roles pathogenesis resolution pain. We review how interact nociceptive neurons by secreting neuroactive signaling molecules modulate Recent studies also suggest bacterial infections regulate through direct actions on sensory neurons, specific receptors are present nociceptors to detect danger signals from infections. discuss new therapeutic strategies control neuroinflammation for prevention treatment

Language: Английский

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The Sleep-Immune Crosstalk in Health and Disease

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(3), P. 1325 - 1380

Published: March 28, 2019

Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, sleep in turn affects the innate adaptive arm of our body’s defense system. Stimulation immune by microbial challenges triggers an inflammatory response, which, depending on its magnitude time course, can induce increase duration intensity, but also a disruption sleep. Enhancement during infection is assumed to feedback promote host defense. Indeed, various parameters, associated with reduced risk, improve outcome vaccination responses. The induction hormonal constellation that supports functions one likely mechanism underlying immune-supporting effects In absence infectious challenge, appears homeostasis through several mediators, such as cytokines. This notion supported findings prolonged deficiency (e.g., short duration, disturbance) lead chronic, systemic low-grade inflammation diseases have component, like diabetes, atherosclerosis, neurodegeneration. Here, we review available data this regulatory sleep-immune crosstalk, point out methodological challenges, suggest questions open for future research.

Language: Английский

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Neuroinflammation and Central Sensitization in Chronic and Widespread Pain

Anesthesiology, Journal Year: 2018, Volume and Issue: 129(2), P. 343 - 366

Published: Feb. 16, 2018

Abstract Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic plasticity, and increased neuronal responsiveness pathways after painful insults. Accumulating evidence suggests that sensitization also driven neuroinflammation the peripheral nervous system. A characteristic feature activation glial cells, such as microglia astrocytes, spinal cord brain, leading to release proinflammatory cytokines chemokines. Recent studies suggest chemokines are powerful neuromodulators play sufficient role inducing hyperalgesia allodynia system administration. Sustained increase promotes chronic widespread affects multiple body sites. Thus, drives via sensitization. We discuss sex-dependent glial/immune signaling new therapeutic approaches control for resolution pain.

Language: Английский

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Astrocyte barriers to neurotoxic inflammation

Nature reviews. Neuroscience, Journal Year: 2015, Volume and Issue: 16(5), P. 249 - 263

Published: April 20, 2015

Language: Английский

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Emerging targets in neuroinflammation-driven chronic pain

Nature Reviews Drug Discovery, Journal Year: 2014, Volume and Issue: 13(7), P. 533 - 548

Published: June 20, 2014

Language: Английский

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Epilepsy

Nature Reviews Disease Primers, Journal Year: 2018, Volume and Issue: 4(1)

Published: May 3, 2018

Language: Английский

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Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

Nature Reviews Neurology, Journal Year: 2019, Volume and Issue: 15(8), P. 459 - 472

Published: July 1, 2019

Language: Английский

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Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression

The Lancet Psychiatry, Journal Year: 2015, Volume and Issue: 2(11), P. 1002 - 1012

Published: Oct. 30, 2015

Language: Английский

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The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

Neuroscience, Journal Year: 2015, Volume and Issue: 300, P. 141 - 154

Published: May 14, 2015

Language: Английский

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Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation

Frontiers in Cellular Neuroscience, Journal Year: 2015, Volume and Issue: 9

Published: Dec. 17, 2015

Patients with chronic inflammation are often associated the emergence of depression symptoms, while diagnosed depressed patients show increased levels circulating cytokines. Further studies revealed activation brain immune cell microglia in a greater magnitude individuals that committed suicide, indicating crucial role for neuroinflammation pathogenesis. Rapid advances understanding microglial and astrocytic neurobiology were obtained past fifteen to twenty years. Indeed, recent data reveal play an important managing neuronal death, neurogenesis, synaptic interactions, besides their involvement immune-response generating The communication between neurons is essential synchronize these diverse functions activity. Evidence accumulating secreted extracellular vesicles (EVs), comprising ectosomes exosomes size ranging from 0.1 1 μm, key players intercellular signaling. These EVs may carry specific proteins, mRNAs microRNAs (miRNAs). Transfer was shown be mediated by oligodendrocytes, astrocytes either supportive neurons, or instead disseminate disease. Interestingly, several reports have identified changes miRNAs patients, which target not only pathways plasticity, learning memory but also production neurotrophic factors modulation. In this article, we discuss depression, namely dynamic alterations status response stimulation, how phenotypes etiological neurodegeneneration, particular depressive-like behavior. We will overview miRNAs, exosomes, regulating critical they contribute other disorders including amyotrophic lateral sclerosis, Alzheimer's disease Parkinson disease, share neuroinflammatory-associated processes. Specific reference made as potential biomarkers monitoring approaches, focusing on potentialities drug delivery vehicles putative therapeutic strategies using autologous exosome-based systems treat neurodegenerative psychiatric disorders.

Language: Английский

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