Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients DOI Creative Commons

Pramod Khosla,

Zulfitri Azuan Mat Daud,

Boniface Tubie

и другие.

Vascular Health and Risk Management, Год журнала: 2013, Номер unknown, С. 747 - 747

Опубликована: Ноя. 1, 2013

Purpose: Chronic hemodialysis patients experience accelerated atherosclerosis contributed to by dyslipidemia, inflammation, and an impaired antioxidant system. Vitamin E tocotrienols possess anti-inflammatory properties. However, the impact of dietary intervention with is unknown in this population. Patients methods: A randomized, double-blind, placebo-controlled, parallel trial was conducted 81 undergoing chronic hemodialysis. Subjects were provided daily capsules containing either vitamin tocotrienol-rich fraction (TRF) (180 mg tocotrienols, 40 tocopherols) or placebo (0.48 0.88 tocopherols). Endpoints included measurements inflammatory markers (C-reactive protein interleukin 6), oxidative status (total power malondialdehyde), lipid profiles (plasma total cholesterol, triacylglycerols, high-density lipoprotein cholesterol), as well cholesteryl-ester transfer activity apolipoprotein A1. Results: TRF supplementation did not any nutritional, inflammatory, biomarkers over time when compared baseline within group (one-way repeated measures analysis variance) at a particular point (independent t-test). supplemented showed improvement after 12 16 weeks respective points. Normalized plasma triacylglycerols (cf baseline) reduced 33 mg/dL ( P =0.032) 36 =0.072) but no significant seen group. Similarly, normalized cholesterol higher <0.05) both week 16. The changes associated A1 concentration <0.02) lower <0.001). Conclusion: improved study maintenance patients. multi-centered warranted confirm these observations. Keyword: vitamin, fraction, profiles, hemodialysis, end-stage renal disease, nutrition

Язык: Английский

SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19 DOI Creative Commons
Hayder M. Al‐kuraishy,

Nawar Raad Hussien,

Marwa S. Al‐Niemi

и другие.

Immunity Inflammation and Disease, Год журнала: 2023, Номер 11(5)

Опубликована: Май 1, 2023

Covid-19 is linked with the development of cardio-metabolic disorders, including dyslipidemia, dysregulation high-density lipoprotein (HDL), and low-density (LDL). Furthermore, SARS-Co-2 infection associated noteworthy changes in lipid profile, which suggested as a possible biomarker to support diagnosis management Covid-19.

Язык: Английский

Процитировано

21

Safety of Nutmeg powder by oral exposure: toxicity prediction and in vivo evaluation DOI
Wei Lv, Xintong Zhang, Hongli Zhang

и другие.

Food and Chemical Toxicology, Год журнала: 2025, Номер 200, С. 115364 - 115364

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Diminished Antioxidant Activity of High-Density Lipoprotein-Associated Proteins in Chronic Kidney Disease DOI
David J. Kennedy, W.H. Wilson Tang, Yiying Fan

и другие.

Journal of the American Heart Association, Год журнала: 2013, Номер 2(2), С. e000104 - e000104

Опубликована: Апрель 4, 2013

Background--Decreased serum arylesterase activity, catalyzed by the high-density lipoprotein-associated paraoxonase (PON)-1, is associated with increased oxidant stress and atherosclerosis risk.We sought to determine prognostic value of PON-1 as monitored PON or activities, in subjects chronic kidney disease (CKD), particularly relation established cardiac biomarkers.Methods Results--Serum activities were measured sequential CKD (n=630; estimated glomerular filtration rate [eGFR] <60 mL/min per 1.73 m 2 ) an age-and sex-matched control group non-CKD (n=315) presenting for evaluations prospectively followed incident (3-year) major adverse events (composite death, nonfatal myocardial infarction, stroke).Serum activity was lower compared that [median (interquartile range) 94 (77 112) versus 103 (85 121) lmol(LÁmin) mL, P<0.001]; similarly, 474 (275 936) 586 (301 1118) nmol(LÁmin) P<0.001].Lower (hazard ratio 1.8, 95% CI 1.26 2.57, P<0.01) a predictor poorer outcomes.After adjusting traditional risk factors medication use, 1.55, 1.08 2.23, P<0.05) still conferred at 3 years.Conclusions--In patients CKD, decreased measure diminished antioxidant properties PON-1, predicts higher long-term cardiovascular (heart attack, stroke, death) multivariable models clinical biochemical factors.(

Язык: Английский

Процитировано

70

Exercise Training Improves HR Responses and V˙O2peak in Predialysis Kidney Patients DOI Open Access
Samuel Headley, Michael J. Germain,

Charles Milch

и другие.

Medicine & Science in Sports & Exercise, Год журнала: 2012, Номер 44(12), С. 2392 - 2399

Опубликована: Дек. 1, 2012

The current pilot and feasibility study was designed to examine the effect of 48 wk moderate-intensity exercise training dietary modification on kidney function vascular parameters in chronic disease (CKD) patients.Twenty-one stage 2-4 CKD patients (age, 18-70 yr) were randomly assigned either group (TG, n = 10) or usual care (n 11) for wk. TG received personal (3 d·wk up 55 min per session at 50%-60% V˙O2peak) counseling, whereas individuals standard instructed not start a structured program while study. V˙O2peak, estimated glomerular filtration rate (eGFR), resting ambulatory HR, plasma lipids (total cholesterol, LDL HDL triglycerides), inflammatory markers (high-sensitivity C-reactive protein interleukin 6) assessed baseline weeks 24 48. An independent group's t-test used compare slopes between groups, all other data analyzed with ANCOVA using value as covariate.There no statistically significant differences any baseline. 48-wk intervention led increase reductions both increases cholesterol TG, but it had change eGFR over time.A program, primarily focused aerobic exercise, V˙O2peak favorably alters autonomic evidenced by HR stages patients. eGFR.

Язык: Английский

Процитировано

68

Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients DOI Creative Commons

Pramod Khosla,

Zulfitri Azuan Mat Daud,

Boniface Tubie

и другие.

Vascular Health and Risk Management, Год журнала: 2013, Номер unknown, С. 747 - 747

Опубликована: Ноя. 1, 2013

Purpose: Chronic hemodialysis patients experience accelerated atherosclerosis contributed to by dyslipidemia, inflammation, and an impaired antioxidant system. Vitamin E tocotrienols possess anti-inflammatory properties. However, the impact of dietary intervention with is unknown in this population. Patients methods: A randomized, double-blind, placebo-controlled, parallel trial was conducted 81 undergoing chronic hemodialysis. Subjects were provided daily capsules containing either vitamin tocotrienol-rich fraction (TRF) (180 mg tocotrienols, 40 tocopherols) or placebo (0.48 0.88 tocopherols). Endpoints included measurements inflammatory markers (C-reactive protein interleukin 6), oxidative status (total power malondialdehyde), lipid profiles (plasma total cholesterol, triacylglycerols, high-density lipoprotein cholesterol), as well cholesteryl-ester transfer activity apolipoprotein A1. Results: TRF supplementation did not any nutritional, inflammatory, biomarkers over time when compared baseline within group (one-way repeated measures analysis variance) at a particular point (independent t-test). supplemented showed improvement after 12 16 weeks respective points. Normalized plasma triacylglycerols (cf baseline) reduced 33 mg/dL ( P =0.032) 36 =0.072) but no significant seen group. Similarly, normalized cholesterol higher <0.05) both week 16. The changes associated A1 concentration <0.02) lower <0.001). Conclusion: improved study maintenance patients. multi-centered warranted confirm these observations. Keyword: vitamin, fraction, profiles, hemodialysis, end-stage renal disease, nutrition

Язык: Английский

Процитировано

65