Vascular Health and Risk Management,
Год журнала:
2013,
Номер
unknown, С. 747 - 747
Опубликована: Ноя. 1, 2013
Purpose:
Chronic
hemodialysis
patients
experience
accelerated
atherosclerosis
contributed
to
by
dyslipidemia,
inflammation,
and
an
impaired
antioxidant
system.
Vitamin
E
tocotrienols
possess
anti-inflammatory
properties.
However,
the
impact
of
dietary
intervention
with
is
unknown
in
this
population.
Patients
methods:
A
randomized,
double-blind,
placebo-controlled,
parallel
trial
was
conducted
81
undergoing
chronic
hemodialysis.
Subjects
were
provided
daily
capsules
containing
either
vitamin
tocotrienol-rich
fraction
(TRF)
(180
mg
tocotrienols,
40
tocopherols)
or
placebo
(0.48
0.88
tocopherols).
Endpoints
included
measurements
inflammatory
markers
(C-reactive
protein
interleukin
6),
oxidative
status
(total
power
malondialdehyde),
lipid
profiles
(plasma
total
cholesterol,
triacylglycerols,
high-density
lipoprotein
cholesterol),
as
well
cholesteryl-ester
transfer
activity
apolipoprotein
A1.
Results:
TRF
supplementation
did
not
any
nutritional,
inflammatory,
biomarkers
over
time
when
compared
baseline
within
group
(one-way
repeated
measures
analysis
variance)
at
a
particular
point
(independent
t-test).
supplemented
showed
improvement
after
12
16
weeks
respective
points.
Normalized
plasma
triacylglycerols
(cf
baseline)
reduced
33
mg/dL
(
P
=0.032)
36
=0.072)
but
no
significant
seen
group.
Similarly,
normalized
cholesterol
higher
<0.05)
both
week
16.
The
changes
associated
A1
concentration
<0.02)
lower
<0.001).
Conclusion:
improved
study
maintenance
patients.
multi-centered
warranted
confirm
these
observations.
Keyword:
vitamin,
fraction,
profiles,
hemodialysis,
end-stage
renal
disease,
nutrition
Immunity Inflammation and Disease,
Год журнала:
2023,
Номер
11(5)
Опубликована: Май 1, 2023
Covid-19
is
linked
with
the
development
of
cardio-metabolic
disorders,
including
dyslipidemia,
dysregulation
high-density
lipoprotein
(HDL),
and
low-density
(LDL).
Furthermore,
SARS-Co-2
infection
associated
noteworthy
changes
in
lipid
profile,
which
suggested
as
a
possible
biomarker
to
support
diagnosis
management
Covid-19.
Medicine & Science in Sports & Exercise,
Год журнала:
2012,
Номер
44(12), С. 2392 - 2399
Опубликована: Дек. 1, 2012
The
current
pilot
and
feasibility
study
was
designed
to
examine
the
effect
of
48
wk
moderate-intensity
exercise
training
dietary
modification
on
kidney
function
vascular
parameters
in
chronic
disease
(CKD)
patients.Twenty-one
stage
2-4
CKD
patients
(age,
18-70
yr)
were
randomly
assigned
either
group
(TG,
n
=
10)
or
usual
care
(n
11)
for
wk.
TG
received
personal
(3
d·wk
up
55
min
per
session
at
50%-60%
V˙O2peak)
counseling,
whereas
individuals
standard
instructed
not
start
a
structured
program
while
study.
V˙O2peak,
estimated
glomerular
filtration
rate
(eGFR),
resting
ambulatory
HR,
plasma
lipids
(total
cholesterol,
LDL
HDL
triglycerides),
inflammatory
markers
(high-sensitivity
C-reactive
protein
interleukin
6)
assessed
baseline
weeks
24
48.
An
independent
group's
t-test
used
compare
slopes
between
groups,
all
other
data
analyzed
with
ANCOVA
using
value
as
covariate.There
no
statistically
significant
differences
any
baseline.
48-wk
intervention
led
increase
reductions
both
increases
cholesterol
TG,
but
it
had
change
eGFR
over
time.A
program,
primarily
focused
aerobic
exercise,
V˙O2peak
favorably
alters
autonomic
evidenced
by
HR
stages
patients.
eGFR.
Vascular Health and Risk Management,
Год журнала:
2013,
Номер
unknown, С. 747 - 747
Опубликована: Ноя. 1, 2013
Purpose:
Chronic
hemodialysis
patients
experience
accelerated
atherosclerosis
contributed
to
by
dyslipidemia,
inflammation,
and
an
impaired
antioxidant
system.
Vitamin
E
tocotrienols
possess
anti-inflammatory
properties.
However,
the
impact
of
dietary
intervention
with
is
unknown
in
this
population.
Patients
methods:
A
randomized,
double-blind,
placebo-controlled,
parallel
trial
was
conducted
81
undergoing
chronic
hemodialysis.
Subjects
were
provided
daily
capsules
containing
either
vitamin
tocotrienol-rich
fraction
(TRF)
(180
mg
tocotrienols,
40
tocopherols)
or
placebo
(0.48
0.88
tocopherols).
Endpoints
included
measurements
inflammatory
markers
(C-reactive
protein
interleukin
6),
oxidative
status
(total
power
malondialdehyde),
lipid
profiles
(plasma
total
cholesterol,
triacylglycerols,
high-density
lipoprotein
cholesterol),
as
well
cholesteryl-ester
transfer
activity
apolipoprotein
A1.
Results:
TRF
supplementation
did
not
any
nutritional,
inflammatory,
biomarkers
over
time
when
compared
baseline
within
group
(one-way
repeated
measures
analysis
variance)
at
a
particular
point
(independent
t-test).
supplemented
showed
improvement
after
12
16
weeks
respective
points.
Normalized
plasma
triacylglycerols
(cf
baseline)
reduced
33
mg/dL
(
P
=0.032)
36
=0.072)
but
no
significant
seen
group.
Similarly,
normalized
cholesterol
higher
<0.05)
both
week
16.
The
changes
associated
A1
concentration
<0.02)
lower
<0.001).
Conclusion:
improved
study
maintenance
patients.
multi-centered
warranted
confirm
these
observations.
Keyword:
vitamin,
fraction,
profiles,
hemodialysis,
end-stage
renal
disease,
nutrition