SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

Nature Reviews Endocrinology, Год журнала: 2017, Номер 13(12), С. 710 - 730

Опубликована: Авг. 29, 2017

Язык: Английский

---

Chronic kidney disease

Nature Reviews Disease Primers, Год журнала: 2017, Номер 3(1)

Опубликована: Ноя. 22, 2017

Язык: Английский

---

Animal models of obesity and diabetes mellitus

Nature Reviews Endocrinology, Год журнала: 2018, Номер 14(3), С. 140 - 162

Опубликована: Янв. 19, 2018

Язык: Английский

---

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

Nature Reviews Nephrology, Год журнала: 2018, Номер 14(6), С. 361 - 377

Опубликована: Апрель 13, 2018

Язык: Английский

---

Obesity, kidney dysfunction and hypertension: mechanistic links

Nature Reviews Nephrology, Год журнала: 2019, Номер 15(6), С. 367 - 385

Опубликована: Апрель 23, 2019

Язык: Английский

---

KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors

Transplantation, Год журнала: 2017, Номер 101(8S), С. S7 - S105

Опубликована: Июль 25, 2017

The 2017 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Care of Living Donors is intended to assist medical professionals who evaluate living kidney donor candidates provide care before, during after donation. guideline development process followed Grades Recommendation Assessment, Development, (GRADE) approach recommendations are based systematic reviews relevant studies that included critical appraisal quality evidence strength recommendations. However, many recommendations, for which there was no or search undertaken by Evidence Review Team, were issued as ungraded expert opinion work group concluded a comprehensive risk assessment should replace decisions assessments single factors in isolation. Original data analyses produce “proof-in-concept” risk-prediction model failure support framework quantitative candidate evaluation defensible shared decision making. This grounded simultaneous consideration each candidate's profile demographic health characteristics. processes presented, along with optimal during, Limitations discussed, especially regarding lack definitive prospective clinical outcome trials. Suggestions future research, including need continued refinement long-term prediction novel approaches estimating donation-attributable risks, also provided. In citing this document, following format be used: Donor Work Group. KDIGO Donors. Transplantation. 2017;101(Suppl 8S):S1–S109.

Язык: Английский

---

Podocytopathies

Nature Reviews Disease Primers, Год журнала: 2020, Номер 6(1)

Опубликована: Авг. 13, 2020

Язык: Английский

---

Single-Nephron Glomerular Filtration Rate in Healthy Adults

New England Journal of Medicine, Год журнала: 2017, Номер 376(24), С. 2349 - 2357

Опубликована: Июнь 14, 2017

The glomerular filtration rate (GFR) assesses the function of all nephrons, and single-nephron GFR individual nephrons. How relates to demographic clinical characteristics kidney-biopsy findings in humans is unknown.We identified 1388 living kidney donors at Mayo Clinic Cleveland who underwent a computed tomographic (CT) scan with use contrast material an iothalamate-based measurement during donor evaluation biopsy donation. mean was calculated as divided by number nephrons (calculated cortical volume both kidneys assessed on CT times biopsy-determined density). Demographic were correlated GFR.A total 58% women, (±SD) age 44±12 years. 115±24 ml per minute, 860,000±370,000 kidney, 80±40 nl minute. did not vary significantly according (among <70 years age), sex, or height ≤190 cm tall). A higher independently associated larger more glomerulosclerosis arteriosclerosis than would be expected for age. 190 cm, obesity, family history end-stage renal disease.Among healthy adult donors, fairly constant regard age, (if cm). certain risk factors chronic disease findings. (Funded National Institute Diabetes Digestive Kidney Diseases.).

Язык: Английский

---

Lipid Accumulation and Chronic Kidney Disease

Nutrients, Год журнала: 2019, Номер 11(4), С. 722 - 722

Опубликована: Март 28, 2019

Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic kidney disease (CKD), suggesting that lipid accumulation in renal parenchyma is detrimental to function. Non-esterified fatty acids (also known as free acids, FFA) especially harmful kidneys. A concerted, increased FFA uptake due high fat diets, overexpression acid systems such CD36 scavenger receptor transport proteins, a reduced β-oxidation rate underlie intracellular non-adipose tissues. FFAs excess can damage podocytes, proximal tubular epithelial cells tubulointerstitial tissue through various mechanisms, particular by boosting production reactive oxygen species (ROS) peroxidation, promoting mitochondrial inflammation, which result glomerular lesions. Not all lipids bad for kidneys: polyunsaturated (PUFA) eicosapentaenoic (EPA) docosahexaenoic (DHA) seem help lag progression (CKD). Lifestyle interventions, dietary adjustments, lipid-lowering drugs contribute improve clinical outcome patients with CKD.

Язык: Английский

---

Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

Molecular Cell, Год журнала: 2021, Номер 81(18), С. 3708 - 3730

Опубликована: Сен. 1, 2021

Язык: Английский

---