Epilepsy and brain inflammation

Experimental Neurology, Год журнала: 2011, Номер 244, С. 11 - 21

Опубликована: Окт. 2, 2011

Язык: Английский

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Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

Nature reviews. Neuroscience, Год журнала: 2013, Номер 15(1), С. 43 - 53

Опубликована: Ноя. 27, 2013

Язык: Английский

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Glial responses to implanted electrodes in the brain

Nature Biomedical Engineering, Год журнала: 2017, Номер 1(11), С. 862 - 877

Опубликована: Ноя. 3, 2017

Язык: Английский

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Review: Hippocampal sclerosis in epilepsy: a neuropathology review

Neuropathology and Applied Neurobiology, Год журнала: 2014, Номер 40(5), С. 520 - 543

Опубликована: Апрель 25, 2014

Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe epilepsy (MTLE) as well other syndromes and both surgical post-mortem practice. The 2013 International League Against Epilepsy (ILAE) classification segregates HS into typical (type 1) atypical 2 3) groups, based on the histological patterns of subfield neuronal loss gliosis. In addition, granule cell reorganization alterations interneuronal populations, neuropeptide fibre networks mossy sprouting are distinctive features associated with epilepsies; they can be useful diagnostic aids to discriminate from causes HS, highlighting potential mechanisms hippocampal epileptogenesis. cause remains elusive may multifactorial; contribution febrile seizures, genetic susceptibility, inflammatory neurodevelopmental factors discussed. Post-mortem research an addition studies samples, has added advantage enabling study wider network changes long-term effects comorbidities. It likely that heterogeneous aspects its cause, epileptogenetic mechanisms, response medical treatments. Future neuropathological will contribute better recognition understanding these clinical patho-aetiological subtypes HS.

Язык: Английский

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The impact of microglial activation on blood-brain barrier in brain diseases

Frontiers in Cellular Neuroscience, Год журнала: 2014, Номер 8

Опубликована: Ноя. 3, 2014

The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells together with neurons and glial cells, including microglia, forms the neurovascular unit. crosstalk between these guarantees a proper environment for brain function. In this context, changes in endothelium-microglia interactions are associated variety inflammation-related diseases brain, where BBB permeability is compromised. Increasing evidences indicate that activated microglia modulate expression tight junctions, which essential integrity On other hand, endothelium can regulate state microglial activation. Here, we review recent advances provide insights into vascular system such as infectious/inflammatory diseases, epilepsy, ischemic stroke neurodegenerative disorders.

Язык: Английский

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The role of inflammation in epileptogenesis

Neuropharmacology, Год журнала: 2012, Номер 69, С. 16 - 24

Опубликована: Апрель 13, 2012

Язык: Английский

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Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

Nature Medicine, Год журнала: 2012, Номер 18(7), С. 1087 - 1094

Опубликована: Июнь 10, 2012

Язык: Английский

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Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

Journal of Neuroscience, Год журнала: 2014, Номер 34(32), С. 10528 - 10540

Опубликована: Авг. 6, 2014

Microglia are highly dynamic immune cells of the CNS and their dynamism is proposed to be regulated by neuronal activities. However, mechanisms underlying regulation microglial have not been determined. Here, we found an increased number primary processes in hippocampus during KA-induced seizure activity. Consistently, global glutamate induced robust process extension toward neurons both brain slices intact in vivo. The mechanism glutamate-induced involves activation NMDA receptors, calcium influx, subsequent ATP release, response through P2Y12 receptors. Seizure-induced increases numbers were also dependent on receptor activation. Finally, that KO mice exhibited reduced seizure-induced worsened behaviors. Our results elucidate molecular microglia–neuron communication may potentially neuroprotective epileptic brain.

Язык: Английский

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Cytokines and brain excitability

Frontiers in Neuroendocrinology, Год журнала: 2011, Номер 33(1), С. 116 - 125

Опубликована: Дек. 27, 2011

Язык: Английский

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IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

Brain Behavior and Immunity, Год журнала: 2011, Номер 25(7), С. 1281 - 1289

Опубликована: Апрель 15, 2011

Язык: Английский

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