Cancer Biology and Medicine,
Год журнала:
2020,
Номер
17(1), С. 44 - 59
Опубликована: Янв. 1, 2020
Since
triple-negative
breast
cancer
(TNBC)
was
first
defined
over
a
decade
ago,
increasing
studies
have
focused
on
its
genetic
and
molecular
characteristics.
Patients
diagnosed
with
TNBC,
compared
to
those
other
subtypes,
relatively
poor
outcomes
due
high
tumor
aggressiveness
lack
of
targeted
treatment.
Metabolic
reprogramming,
an
emerging
hallmark
cancer,
is
hijacked
by
TNBC
fulfill
bioenergetic
biosynthetic
demands;
maintain
the
redox
balance;
further
promote
oncogenic
signaling,
cell
proliferation,
metastasis.
Understanding
mechanisms
metabolic
remodeling
may
guide
design
strategies
for
effective
intervention
TNBC.
Here,
we
review
reprogramming
glycolysis,
oxidative
phosphorylation,
amino
acid
metabolism,
lipid
branched
pathways
in
explore
opportunities
new
biomarkers,
imaging
modalities,
metabolically
therapies.
Annual Review of Biomedical Engineering,
Год журнала:
2017,
Номер
19(1), С. 163 - 194
Опубликована: Март 16, 2017
Glutamine
is
the
most
abundant
circulating
amino
acid
in
blood
and
muscle
critical
for
many
fundamental
cell
functions
cancer
cells,
including
synthesis
of
metabolites
that
maintain
mitochondrial
metabolism;
generation
antioxidants
to
remove
reactive
oxygen
species;
nonessential
acids
(NEAAs),
purines,
pyrimidines,
fatty
cellular
replication;
activation
signaling.
In
light
pleiotropic
role
glutamine
a
comprehensive
understanding
metabolism
essential
development
metabolic
therapeutic
strategies
targeting
cells.
this
article,
we
review
oncogene-,
tumor
suppressor-,
microenvironment-mediated
regulation
We
describe
mechanism
glutamine's
proliferation,
metastasis,
global
methylation.
Furthermore,
highlight
potential
emphasize
clinical
application
vivo
assessment
identifying
new
ways
treat
patients
through
glutamine-based
therapy.
Frontiers in Immunology,
Год журнала:
2018,
Номер
9
Опубликована: Июль 30, 2018
Unrestricted
cell
proliferation
is
a
hallmark
of
cancer.
Purines
are
basic
components
nucleotides
in
proliferation,
thus
impaired
purine
metabolism
associated
with
the
progression
The
de
novo
biosynthesis
depends
on
six
enzymes
to
catalyze
conversion
phosphoribosylpyrophosphate
inosine
5'-monophosphate.
These
cluster
around
mitochondria
and
microtubules
form
purinosome,
which
multi-enzyme
complex
involved
requirement.
In
this
review,
we
highlighted
purinosome
biology
emphasis
therapeutic
potential
manipulating
or
cancers.
We
also
reviewed
current
advances
our
understanding
mammalian
target
rapamycin
(mTOR)
for
regulating
formation
cancers,
discussed
future
prospects
targeting
treat
Frontiers in Cell and Developmental Biology,
Год журнала:
2021,
Номер
8
Опубликована: Янв. 12, 2021
Metabolic
reprogramming
has
been
widely
recognized
as
a
hallmark
of
malignancy.
The
uptake
and
metabolism
amino
acids
are
aberrantly
upregulated
in
many
cancers
that
display
addiction
to
particular
acids.
Amino
facilitate
the
survival
proliferation
cancer
cells
under
genotoxic,
oxidative,
nutritional
stress.
Thus,
targeting
acid
is
becoming
potential
therapeutic
strategy
for
patients.
In
this
review,
we
will
systematically
summarize
recent
progress
malignancy
discuss
their
interconnection
with
mammalian
target
rapamycin
complex
1
(mTORC1)
signaling,
epigenetic
modification,
tumor
growth
immunity,
ferroptosis.
Finally,
highlight
applications.
