New insights into long noncoding RNAs and their roles in glioma

Molecular Cancer, Год журнала: 2018, Номер 17(1)

Опубликована: Фев. 19, 2018

Glioma is one of the most prevalent types primary intracranial carcinoma with varying malignancy grades I–IV and histological subtypes, including astrocytomas, glioblastoma multiform (GBM), oligodendrogliomas mixed tumors. characterized by rapid cell proliferation angiogenesis, WHO grade IV glioblastoma, which highly malignant poor prognosis because GBM stem-like cells (GSCs) are resistant to conventional therapy easily recrudescent, accounts for majority gliomas. Consequently, investigations exploring accurate molecular mechanisms reliable therapeutic targets gliomas have drawn extensive attention. Based on increasing amount functional lncRNAs aberrantly expressed in glioma tissues lines, might be critical initiation, progression other phenotypes. This review summarizes latest insights into lncRNA field their roles glioma, therefore evaluating potential clinical applications as prospective novel biomarkers targets.

Язык: Английский

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Mechanisms of lncRNA/microRNA interactions in angiogenesis

Life Sciences, Год журнала: 2019, Номер 254, С. 116900 - 116900

Опубликована: Ноя. 28, 2019

Язык: Английский

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Biological Function of Long Non-coding RNA (LncRNA) Xist

Frontiers in Cell and Developmental Biology, Год журнала: 2021, Номер 9

Опубликована: Июнь 10, 2021

Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating evidence suggests that lncRNA X-inactive specific transcript (lncRNA Xist) serves as an important regulator cell growth development. Despites its original roles X-chromosome dosage compensation, Xist also participates the development tumor other human diseases by functioning competing endogenous RNA (ceRNA). In this review, we comprehensively summarized recent progress understanding cellular functions mammalian cells discussed current knowledge regarding ceRNA network various diseases. are transcripts more than 200 nt length without apparent protein-coding capacity (Furlan Rougeulle, 2016; Maduro et al., 2016). These believed to be transcribed approximately 98-99% regions genome (Derrien 2012; Fu, 2014; Montalbano 2017; Slack Chinnaiyan, 2019), well large genomic regions, such exonic, tronic, intergenic regions. Hence, lncRNAs divided into eight categories: Intergenic lncRNAs, Intronic Enhancer Promoter Natural antisense/sense Small nucleolar RNA-ended (sno-lncRNAs), Bidirectional non-poly(A) (Ma 2013; Devaux 2015; St Laurent Chen, Quinn Chang, Richard Eichhorn, 2018; Connerty 2020). A range has suggested function key regulators crucial functions, including proliferation, differentiation, apoptosis, migration, invasion, regulating level target genes via epigenomic, or post-transcriptional approaches (Cao 2018). Moreover, detected body fluids were serve potential biomarkers for diagnosis, prognosis, monitoring disease progression, act novel drug targets therapeutic exploitation (Jiang W. Zhou 2019a). set 15,000-20,000 sequences localized X chromosome inactivation center (XIC) Xq13.2 (Brown 1992; Debrand 1998; Kay, Lee da Rocha Heard, Yang Z. Brockdorff, 2019). Previous studies have indicated (XCI), resulting inheritable silencing one X-chromosomes during female Also, it vital regulatory whole spectrum (notably cancer) can used diagnostic prognostic biomarker clinic (Liu 2018b; Deng 2019; Dinescu Mutzel Schulz, 2020; Patrat Wang 2020a). particular, been demonstrated involved multiple types tumors brain tumor, Leukemia, lung cancer, breast liver with prominent examples outlined Table 1. It was (Chaligne 2018) contributed diseases, pulmonary fibrosis, inflammation, neuropathic pain, cardiomyocyte hypertrophy, osteoarthritis chondrocytes, details found 2. This review summarizes on mechanisms both compensation pathogenesis (especially processes, focus disease.

Язык: Английский

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Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease

Theranostics, Год журнала: 2018, Номер 8(13), С. 3654 - 3675

Опубликована: Янв. 1, 2018

Long noncoding RNAs (lncRNAs) represent a large subgroup of that are longer than 200 nucleotides and have no apparent protein coding potential.They diverse functions in different biological processes by regulating chromatin remodeling or translation.This review summarizes the recent progress lncRNAs angiogenesis vascular diseases.A general overview lncRNA functional mechanisms will be introduced.A list lncRNAs, which termed "Angio-LncRs", including MALAT1, MANTIS, PUNISHER, MEG3, MIAT, SENCR GATA6-AS, discussed regarding their expression, regulation, function mechanism action angiogenesis.Implications diseases, such as atherosclerosis, hypertension, retinopathies tumor also discussed.

Язык: Английский

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Non-Coding RNAs in Glioma

Cancers, Год журнала: 2018, Номер 11(1), С. 17 - 17

Опубликована: Дек. 22, 2018

Glioma is the most aggressive brain tumor of central nervous system. The ability glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained proliferation, heterogeneity contribute an overall survival approximately 15 months for patients with high grade glioma. Numerous studies indicate that non-coding RNA species have critical functions across biological processes regulate initiation progression. Recently, new data emerged, which shows cross-regulation between long RNAs small phenotypic diversity glioblastoma subclasses. In this paper, we review expression, was evaluated in human tissue samples during a five-year period. Thus, summarizes following: (I) role pathogenesis, (II) potential application glioma-grading, (III) crosstalk lncRNAs miRNAs (IV) future perspectives as biomarkers

Язык: Английский

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SNHG16/miR-216-5p/ZEB1 signal pathway contributes to the tumorigenesis of cervical cancer cells

Archives of Biochemistry and Biophysics, Год журнала: 2017, Номер 637, С. 1 - 8

Опубликована: Ноя. 7, 2017

Язык: Английский

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The Roles of miRNA in Glioblastoma Tumor Cell Communication: Diplomatic and Aggressive Negotiations

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(6), С. 1950 - 1950

Опубликована: Март 12, 2020

Glioblastoma (GBM) consists of a heterogeneous collection competing cellular clones which communicate with each other and the tumor microenvironment (TME). MicroRNAs (miRNAs) present various exchange mechanisms: free miRNA, extracellular vesicles (EVs), or gap junctions (GJs). GBM cells transfer miR-4519 miR-5096 to astrocytes through GJs. Oligodendrocytes located in invasion front high levels miR-219-5p, miR-219-2-3p, miR-338-3p, all related their differentiation. There is reciprocal between endothelial (ECs) as promotes angiogenesis after being transferred into ECs, whereas miR-145-5p acts suppressor. In glioma stem (GSCs), miR-1587 miR-3620-5p increase proliferation inhibits hormone receptor co-repressor-1 (NCOR1) EVs transfers. GBM-derived carry miR-21 miR-451 that are up-taken by microglia monocytes/macrophages, promoting proliferation. Macrophages release enriched cells. This bidirectional increases STAT3 activity macrophages, invasion, proliferation, angiogenesis, resistance treatment. miR-1238 upregulated resistant EVs, conferring adjacent via CAV1/EGFR signaling pathway. Decrypting these mechanisms could lead better patient stratification development novel target therapies.

Язык: Английский

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Roles of lncRNAs in cancer: Focusing on angiogenesis

Life Sciences, Год журнала: 2020, Номер 252, С. 117647 - 117647

Опубликована: Апрель 8, 2020

Язык: Английский

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LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

Molecular Therapy — Nucleic Acids, Год журнала: 2021, Номер 24, С. 728 - 742

Опубликована: Апрель 2, 2021

Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed GBM. These lncRNAs possess unique regulatory functions GBM cells, ranging from high invasion/migration to recurrence. This review outlines present status specific involvement pathogenesis, with a focus on their association key molecular cellular mechanisms. Also, we highlighted potential different novel RNA-based strategies that may be beneficial for therapeutic purposes.

Язык: Английский

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Tight junctions and their regulation by non-coding RNAs

International Journal of Biological Sciences, Год журнала: 2021, Номер 17(3), С. 712 - 727

Опубликована: Янв. 1, 2021

Tight junction (TJ) is a "zippering up" structure located at the uppermost portion of adjacent epithelial/endothelial cells in organs and tissues.TJs maintain relative stability intracellular substances functions by closing or opening intercellular pathways, coordinating entry exit molecules different sizes charges, regulating permeability paracellular barrier.TJs also prevent microbial invasion, cell polarity, regulate proliferation.TJs are widely present skin mucosal epithelial barriers, intestinal barrier, glomerular filtration bladder blood-brain brain-blood tumor blood-testis barrier.TJ dysfunction can lead to variety diseases.In addition signal transcription factors, DNA methylation, histone modification, TJ proteins be regulated non-coding RNAs, such as micro-RNAs, long-noncoding circular directly indirectly.This review summarizes TJs introduces regulatory mechanisms tissues.The roles RNAs regulation highlighted this review.

Язык: Английский

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